Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0085 | 0.4513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Peroxidasin | 0.0031 | 0.0706 | 0.1565 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0085 | 0.4513 | 0.1174 |
Echinococcus granulosus | roundabout 2 | 0.0061 | 0.2872 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Schistosoma mansoni | septate junction protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0031 | 0.0706 | 0.2459 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0706 | 0.2459 |
Echinococcus granulosus | peroxidasin | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | Immunoglobulin | 0.0031 | 0.0691 | 0.2406 |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0028 | 0.0525 | 0.1827 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0048 | 0.1922 | 0.4259 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0031 | 0.0706 | 0.2459 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0085 | 0.4513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | contactin | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | neuroglian | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | roundabout 2 | 0.0061 | 0.2872 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0031 | 0.0691 | 0.2406 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0048 | 0.1922 | 0.4259 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0085 | 0.4513 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0031 | 0.0691 | 0.1531 |
Echinococcus multilocularis | hemicentin 1 | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | nephrin | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | titin | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0085 | 0.4513 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.1397 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2872 | 0.6365 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0028 | 0.0525 | 0.1827 |
Echinococcus multilocularis | neuroglian | 0.0051 | 0.2166 | 0.7541 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2872 | 0.6365 |
Echinococcus granulosus | lachesin | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | peroxidasin | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | neuroglian | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1397 | 0.3096 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0041 | 0.1397 | 0.4864 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | neuroglian | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | nephrin | 0.0051 | 0.2166 | 0.48 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0085 | 0.4513 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | septate junction protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Prion-like- | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | hemicentin 1 | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0028 | 0.0525 | 0.1163 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | tyrosine kinase | 0.0038 | 0.1231 | 0.2728 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0162 | 1 | 1 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0085 | 0.4513 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0028 | 0.0525 | 0.1163 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0031 | 0.0691 | 0.2406 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | Immunoglobulin | 0.0031 | 0.0691 | 0.2406 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.0706 | 0.1565 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0028 | 0.0525 | 0.1163 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | roundabout | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | twitchin | 0.0051 | 0.2166 | 0.7541 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | hemicentin 1 | 0.0031 | 0.0706 | 0.2459 |
Echinococcus granulosus | neuroglian | 0.0051 | 0.2166 | 0.7541 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | lachesin | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | TK protein kinase | 0.0028 | 0.0525 | 0.1163 |
Schistosoma mansoni | vesicular amine transporter | 0.0031 | 0.0691 | 0.1531 |
Echinococcus multilocularis | Immunoglobulin | 0.0031 | 0.0691 | 0.2406 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as survival upto 60 days at 25 mg/kg, po | ChEMBL. | 16913722 |
IC50 (functional) | > 205 uM | Cytotoxicity against rat L6 cells | ChEMBL. | 16913722 |
IC50 (functional) | = 1600 uM | Antiprotozoal activity against Plasmodium falciparum K1 | ChEMBL. | 16913722 |
IC50 (functional) | = 1600 uM | Antiprotozoal activity against Plasmodium falciparum K1 | ChEMBL. | 16913722 |
IC50 (functional) | = 24000 uM | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 16913722 |
IC50 (functional) | = 24000 uM | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 16913722 |
Survival (functional) | = 6.25 day | Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as average days of survival at 25 mg/kg, po | ChEMBL. | 16913722 |
Survival (functional) | = 6.25 day | Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as average days of survival at 25 mg/kg, po | ChEMBL. | 16913722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.