Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.161 | 0.3625 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0517 | 0.4442 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0517 | 0.4442 | 0.4442 |
Onchocerca volvulus | Putative cubilin | 0.0154 | 0.0068 | 0.0068 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0154 | 0.0068 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0527 | 0.456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Onchocerca volvulus | Slit protein homolog | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Onchocerca volvulus | 0.0154 | 0.0068 | 0.0068 | |
Echinococcus multilocularis | enteropeptidase | 0.0527 | 0.456 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0184 | 0.043 | 0.0805 |
Onchocerca volvulus | 0.0184 | 0.043 | 0.043 | |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.161 | 0.161 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0282 | 0.161 | 0.1553 |
Onchocerca volvulus | 0.0154 | 0.0068 | 0.0068 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0527 | 0.456 | 0.4523 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | Cadherin domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0517 | 0.4442 | 0.9737 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0527 | 0.456 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0184 | 0.043 | 0.0805 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0154 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0184 | 0.043 | 0.043 | |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.043 | 0.043 |
Giardia lamblia | High cysteine protein | 0.0154 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0517 | 0.4442 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0184 | 0.043 | 0.043 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.161 | 0.161 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Brugia malayi | Muscle positioning protein 4 | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.161 | 0.161 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0517 | 0.4442 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0517 | 0.4442 | 0.4404 |
Loa Loa (eye worm) | trypsin family protein | 0.0184 | 0.043 | 0.043 |
Brugia malayi | Delta serrate ligand family protein | 0.0154 | 0.0068 | 0.0068 |
Echinococcus multilocularis | laminin | 0.0282 | 0.161 | 0.3434 |
Leishmania major | hypothetical protein, conserved | 0.0517 | 0.4442 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0184 | 0.043 | 0.0364 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.098 | 1 | 1 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.161 | 0.161 |
Loa Loa (eye worm) | Notch2 | 0.0154 | 0.0068 | 0.0068 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0184 | 0.043 | 0.0805 |
Onchocerca volvulus | 0.0796 | 0.7792 | 0.7792 | |
Onchocerca volvulus | 0.0154 | 0.0068 | 0.0068 | |
Brugia malayi | Trypsin family protein | 0.0184 | 0.043 | 0.043 |
Brugia malayi | Protein kinase domain containing protein | 0.0517 | 0.4442 | 0.4442 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.043 | 0.043 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0184 | 0.043 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | notch-like transmembrane receptor | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0154 | 0.0068 | 0.0068 | |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.161 | 0.161 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.043 | 0.043 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0517 | 0.4442 | 0.4442 |
Toxoplasma gondii | PAN domain-containing protein | 0.0428 | 0.3369 | 0.7585 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.043 | 0.0364 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0184 | 0.043 | 0.0805 |
Loa Loa (eye worm) | notch protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Onchocerca volvulus | Arrow homolog | 0.0282 | 0.161 | 0.161 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0154 | 0.0068 | 0.0068 | |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.161 | 0.161 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0517 | 0.4442 | 0.9737 |
Echinococcus granulosus | enteropeptidase | 0.0527 | 0.456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.098 | 1 | 1 |
Onchocerca volvulus | 0.0184 | 0.043 | 0.043 | |
Toxoplasma gondii | PAN domain-containing protein | 0.0428 | 0.3369 | 0.7585 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0154 | 0.0068 | 0.0068 |
Echinococcus granulosus | laminin | 0.0282 | 0.161 | 0.3434 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0184 | 0.043 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Echinococcus granulosus | Tolloid protein 1 | 0.0282 | 0.161 | 0.3434 |
Loa Loa (eye worm) | hypothetical protein | 0.098 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0282 | 0.161 | 0.3434 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0184 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.161 | 0.161 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0282 | 0.161 | 0.3434 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.161 | 0.161 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0282 | 0.161 | 0.161 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.043 | 0.043 |
Mycobacterium ulcerans | hypothetical protein | 0.0184 | 0.043 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0517 | 0.4442 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Brugia malayi | hypothetical protein | 0.0184 | 0.043 | 0.043 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.161 | 0.3625 |
Echinococcus granulosus | Mastin | 0.0527 | 0.456 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.043 | 0.0364 |
Schistosoma mansoni | egf-like domain protein | 0.0282 | 0.161 | 0.1553 |
Onchocerca volvulus | 0.0517 | 0.4442 | 0.4442 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.0184 | 0.043 | 0.043 |
Onchocerca volvulus | 0.0184 | 0.043 | 0.043 | |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0282 | 0.161 | 0.161 |
Echinococcus multilocularis | Mastin | 0.0527 | 0.456 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Brugia malayi | Trypsin family protein | 0.0184 | 0.043 | 0.043 |
Brugia malayi | EGF-like domain containing protein | 0.0154 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0517 | 0.4442 | 0.4442 |
Onchocerca volvulus | 0.0184 | 0.043 | 0.043 | |
Brugia malayi | Fibulin-1 precursor | 0.0282 | 0.161 | 0.161 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0068 | 0.0068 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0184 | 0.043 | 0.0364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration measured against Mycobacterium tuberculosis H37Rv strain | ChEMBL. | 15837313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.