Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase-like protein | 0.1606 | 0.8163 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1606 | 0.8163 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1606 | 0.8163 | 1 |
Entamoeba histolytica | ankyrin, putative | 0.0072 | 0.0161 | 0.0218 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.0949 | 0.1121 |
Echinococcus granulosus | carbonic anhydrase | 0.0738 | 0.3635 | 0.4342 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1461 | 0.7407 | 0.8751 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1606 | 0.8163 | 0.7952 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1606 | 0.8163 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1663 | 0.8464 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1606 | 0.8163 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0243 | 0.1052 | 0.2097 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1663 | 0.8464 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0738 | 0.3635 | 0.3654 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0904 | 0.45 | 0.8969 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.3635 | 0.2905 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.0949 | 0.1105 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1003 | 0.5017 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.0949 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0738 | 0.3635 | 1 |
Mycobacterium ulcerans | transferase | 0.007 | 0.0147 | 0.0174 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0738 | 0.3635 | 0.2905 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1663 | 0.8464 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.0949 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1606 | 0.8163 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.0949 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0738 | 0.3635 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0243 | 0.1052 | 0.1247 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1461 | 0.7407 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0211 | 0.0882 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1606 | 0.8163 | 1 |
Onchocerca volvulus | 0.0211 | 0.0882 | 1 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.08 | 0.396 | 0.7893 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.0949 | 0.0965 |
Echinococcus granulosus | carbonic anhydrase | 0.0738 | 0.3635 | 0.4342 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1606 | 0.8163 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1461 | 0.7407 | 0.9075 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.0949 | 0.1892 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1461 | 0.7407 | 1 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0072 | 0.0161 | 0.0322 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0738 | 0.3635 | 0.3654 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1606 | 0.8163 | 0.7952 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0738 | 0.3635 | 0.3654 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0072 | 0.0161 | 0.1699 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0738 | 0.3635 | 0.3654 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1606 | 0.8163 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.3635 | 0.2905 |
Schistosoma mansoni | carbonic anhydrase | 0.1461 | 0.7407 | 0.8331 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0738 | 0.3635 | 0.3654 |
Entamoeba histolytica | acetyltransferase, putative | 0.0072 | 0.0161 | 0.0218 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0072 | 0.0161 | 0.1699 |
Echinococcus granulosus | carbonic anhydrase | 0.0738 | 0.3635 | 0.4342 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1606 | 0.8163 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.