Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Fxna peptidase homolog | 0.0594 | 0.1377 | 0.1129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0594 | 0.1377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0594 | 0.1377 | 0.1129 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0594 | 0.1377 | 0.1129 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.3735 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.3735 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0594 | 0.1377 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.3735 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0594 | 0.1377 | 0.1129 |
Leishmania major | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Brugia malayi | FXNA | 0.0594 | 0.1377 | 0.1129 |
Mycobacterium ulcerans | hypothetical protein | 0.0594 | 0.1377 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.022 | 0.0349 | 0.0349 |
Schistosoma mansoni | glutamate receptor NMDA | 0.022 | 0.0349 | 0.0072 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0594 | 0.1377 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0594 | 0.1377 | 0.1129 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0594 | 0.1377 | 0.1129 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0594 | 0.1377 | 0.1129 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.3735 | 1 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.3735 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.0279 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0594 | 0.1377 | 0.1377 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0594 | 0.1377 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0594 | 0.1377 | 0.1129 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.0279 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.022 | 0.0349 | 0.0349 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0594 | 0.1377 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0594 | 0.1377 | 0.1129 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0594 | 0.1377 | 0.1377 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.0279 | 0.0279 |
Leishmania major | hypothetical protein, conserved | 0.0594 | 0.1377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Mycobacterium tuberculosis | Conserved protein | 0.0594 | 0.1377 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0279 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0594 | 0.1377 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0594 | 0.1377 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0594 | 0.1377 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0594 | 0.1377 | 1 |
Onchocerca volvulus | 0.0594 | 0.1377 | 0.1129 | |
Brugia malayi | nicalin | 0.0594 | 0.1377 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1377 | 0.1129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2 uM | The compound was evaluated for the inhibition of dTMP synthetase from Lactobacillus casei | ChEMBL. | 6796687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.