Detailed information for compound 402441

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 3565.18 | Formula: C161H271N49O42
  • H donors: 49 H acceptors: 44 LogP: -12 Rotable bonds: 142
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCC[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C)Cc1nc[nH]c1)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]([C@H](CC)C)C(=O)N)[C@H](CC)C)CCC(=O)O)CCCC)CC(C)C)CCCCN)CCCN=C(N)N)CC(=O)N)CCC(=O)N)C)CC(C)C)CCC(=O)N)CCC(=O)O)C)CCCN=C(N)N)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC([C@H](NC(=O)[C@H](Cc1ccccc1)N)Cc1nc[nH]c1)O)CC(C)C)CC(C)C)CCCN=C(N)N)CCC(=O)O)CC(C)C)CCC(=O)O
  • InChi: 1S/C161H271N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128,155,205,249H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88-,89-,90-,91+,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,155?/m0/s1
  • InChiKey: FQOBWZLJWYFNDA-BYBYIQGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0164 0.0703 0.2484
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0089 0.0217 0.0522
Loa Loa (eye worm) hypothetical protein 0.0075 0.0125 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0199 0.0924 0.2559
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0448 0.2541 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3338
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0448 0.2541 0.7905
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0448 0.2541 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0089 0.0217 0.0499
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0099 0.0279 0.0371
Echinococcus granulosus serine protein kinase ATM 0.0122 0.0426 0.0334
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0122 0.0426 0.1231
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0345 0.1874 0.7375
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0265 0.1353 0.1269
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0282 0.1467 0.7543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3337
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0348 0.1891 0.7442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3338
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0089 0.0217 0.0571
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0345 0.1874 0.5621
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0099 0.0279 0.0371
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0265 0.1353 0.1269
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0345 0.1874 0.7273
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0208 0.0985 0.3304
Trypanosoma brucei hypothetical protein, conserved 0.0089 0.0217 0.1693
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0329 0.0958
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0448 0.2541 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0345 0.1874 0.1796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3338
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0099 0.0279 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0985 0.3877
Entamoeba histolytica protein kinase rad3, putative 0.0107 0.0329 0.0483
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0099 0.0279 0.0512
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0099 0.0279 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0527 0.2075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0787 0.3098
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0089 0.0217 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0164 0.0703 0.1693
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0448 0.2541 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0348 0.1891 0.7442
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0199 0.0929 0.3062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0924 0.3637
Giardia lamblia GTOR 0.0208 0.0985 0.4634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0787 0.3098
Leishmania major phosphatidylinositol 3-kinase, putative 0.0099 0.0279 0.0699
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0208 0.0985 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0451 0.1775
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0089 0.0217 0.034
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0624 0.3683 0.3622
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0099 0.0279 0.1097
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0099 0.0279 0.0751
Loa Loa (eye worm) hypothetical protein 0.0117 0.0397 0.0954
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0199 0.0924 0.9344
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0448 0.2541 1
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0089 0.0217 0.0123
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0107 0.0329 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0787 0.3098
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0089 0.0217 0.0123
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.0426 0.1354
Toxoplasma gondii FATC domain-containing protein 0.0122 0.0426 0.1942
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0164 0.0703 0.2089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0164 0.0703 0.2089
Schistosoma mansoni fkbp-rapamycin associated protein 0.0107 0.0329 0.0653
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0279 0.0766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3337
Giardia lamblia Rab geranylgeranyltransferase 0.0345 0.1874 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0863 0.3398
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0188 0.0858 0.8629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0208 0.0985 0.3638
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0075 0.0125 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0924 0.3637
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0176 0.078 0.28
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0028 0.0109
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0345 0.1874 0.7375
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0028 0.0109
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0229 0.112 0.1035
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0448 0.2541 0.7905
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0208 0.0985 0.2734
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0089 0.0217 0.1693
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0089 0.0217 0.0123
Entamoeba histolytica hypothetical protein 0.0383 0.2117 0.8176
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0099 0.0279 0.0185
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0099 0.0279 0.058
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0107 0.0329 0.0236
Loa Loa (eye worm) phosphatidylinositol 3 0.0559 0.3259 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0208 0.0985 0.3304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0329 0.1297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0466 0.1836
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0089 0.0217 0.1693
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0122 0.0426 0.3955
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0099 0.0279 0.0185
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0208 0.0985 0.2734
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0279 0.0571
Loa Loa (eye worm) hypothetical protein 0.0345 0.1874 0.5621
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0345 0.1874 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0229 0.112 0.2857
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0164 0.0703 0.2766
Loa Loa (eye worm) hypothetical protein 0.0107 0.0329 0.074
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0089 0.0217 0.1693
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0118 0.04 0.0788
Leishmania major hypothetical protein, conserved 0.0597 0.3506 1
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0217 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0099 0.0279 0.0265
Toxoplasma gondii target of rapamycin (TOR), putative 0.0196 0.0909 0.6421
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0279 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0397 0.1563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3337
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0229 0.112 0.3421
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0345 0.1874 0.7375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0208 0.0985 0.2994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0863 0.3398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0924 0.3637
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0279 0.0766
Toxoplasma gondii hypothetical protein 0.0256 0.1294 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0985 0.3877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0451 0.1775
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0089 0.0217 0.0123
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0099 0.0279 0.0185
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0164 0.0703 0.2766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0924 0.3637
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.1353 0.5141
Leishmania major phosphatidylinositol 3-kinase, putative 0.0177 0.0787 0.2164
Trypanosoma cruzi hypothetical protein, conserved 0.055 0.3204 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Loa Loa (eye worm) phosphatidylinositol 3 0.0208 0.0985 0.2812
Echinococcus multilocularis serine protein kinase ATM 0.0122 0.0426 0.0334
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0624 0.3683 0.3622
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0112 0.0363 0.0881
Trypanosoma cruzi target of rapamycin kinase 3 0.0199 0.0924 0.2803
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1599 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0122 0.0426 0.0923
Entamoeba histolytica hypothetical protein 0.0122 0.0426 0.09
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0099 0.0279 0.0265
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0118 0.0401 0.1151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0383 0.2117 0.8176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.04 0.1576
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0208 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0265 0.1353 0.3974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0985 0.3877
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0208 0.0985 0.2994
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0095 0.0375
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0208 0.0985 0.0898
Loa Loa (eye worm) phosphatidylinositol 3 0.0188 0.0858 0.2411
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0624 0.3683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0924 0.3637
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0279 0.0571
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0345 0.1874 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196 0.0909 0.3577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0787 0.3098
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0208 0.0985 0.0898
Echinococcus multilocularis Zinc finger, PHD finger 0.0099 0.0279 0.0185
Onchocerca volvulus 0.0089 0.0217 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0426 0.1678
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0208 0.0985 0.248
Loa Loa (eye worm) phosphatidylinositol 3 0.0118 0.0401 0.0966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0848 0.3338
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0164 0.0703 0.2103
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0345 0.1874 0.4957
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0089 0.0217 0.0386
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0188 0.0858 0.2369
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0089 0.0217 0.0571
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0089 0.0217 0.0855
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0107 0.0329 0.0925
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0345 0.1874 0.1796
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0127 0.0458 0.4297
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0401 0.2239 0.8701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0858 0.3378
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0229 0.112 0.3421
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0164 0.0703 0.6945
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0229 0.112 0.4191
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0164 0.0703 0.2766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0451 0.1775
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0117 0.0397 0.1669
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0217 0.0571
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0229 0.112 0.1035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0138 0.0534 0.2102
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0345 0.1874 0.713
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0279 0.2358
Loa Loa (eye worm) hypothetical protein 0.0183 0.0826 0.2308
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0256 0.1294 0.5093
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0099 0.0279 0.0512
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0177 0.0787 0.786

Activities

Activity type Activity value Assay description Source Reference
IA (functional) = 0 % The percent intrinsic activity, determined by level of antagonist induced secretion ChEMBL. 9357532
Relative potency (functional) = 32 In vitro relative potency versus [DPhe12,Nle21,38]-hCRF(12-41), using rat pituitary culture assay ChEMBL. 9357532

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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