Detailed information for compound 402777

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1192.2 | Formula: C50H72N8NaO22S
  • H donors: 15 H acceptors: 20 LogP: -1.84 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCOc1ccc(cc1)C(=O)N[C@@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@H](CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)[C@H](O)C)C[C@@H](C2)O)[C@H]([C@H](c1ccc(c(c1)OS(=O)(=O)[O-])O)O)O)[C@H](CC(=O)N)O)C.[NaH+]
  • InChi: 1S/C50H72N8O22S.Na/c1-4-5-6-7-8-9-16-79-28-13-10-25(11-14-28)43(68)52-29-19-33(63)46(71)56-48(73)39-40(65)23(2)21-58(39)50(75)37(32(62)20-35(51)64)54-47(72)38(42(67)41(66)26-12-15-31(61)34(17-26)80-81(76,77)78)55-45(70)30-18-27(60)22-57(30)49(74)36(24(3)59)53-44(29)69;/h10-15,17,23-24,27,29-30,32-33,36-42,46,59-63,65-67,71H,4-9,16,18-22H2,1-3H3,(H2,51,64)(H,52,68)(H,53,69)(H,54,72)(H,55,70)(H,56,73)(H,76,77,78);/q;+1/p-1/t23-,24+,27+,29?,30-,32+,33+,36-,37-,38-,39-,40-,41-,42-,46-;/m0./s1
  • InChiKey: VCJAYEAXNHINIG-DDTRAILPSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Schistosoma mansoni adapter molecule crk 0.0534 0.5533 0.5948
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus suppressor of cytokine signaling 6 0.0534 0.5533 0.5943
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Plasmodium vivax tyrosine kinase-like protein, putative 0.0346 0.3488 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0534 0.5533 0.5533
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0346 0.3488 0.9983
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine protein kinase Btk29A 0.088 0.9302 0.9992
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0129 0.0129
Echinococcus multilocularis tensin 0.0534 0.5533 0.5533
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0346 0.3488 0.3747
Onchocerca volvulus 0.088 0.9302 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.1131 0.1131
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0534 0.5533 0.5948
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0346 0.3488 0.3488
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus expressed conserved protein 0.0534 0.5533 0.5943
Echinococcus multilocularis expressed conserved protein 0.0108 0.0891 0.0891
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0313 0.0843
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Brugia malayi Guanylyl cyclase protein 23 0.0346 0.3488 0.375
Echinococcus multilocularis tyrosine protein kinase ABL1 0.088 0.9302 0.9302
Echinococcus granulosus tyrosine kinase 0.0346 0.3488 0.3747
Echinococcus granulosus tyrosine protein kinase Fps85D 0.088 0.9302 0.9992
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi RhoGAP domain containing protein 0.0534 0.5533 0.5948
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Echinococcus multilocularis tyrosine protein kinase Fyn 0.088 0.9302 0.9302
Loa Loa (eye worm) protein kinase domain-containing protein 0.0346 0.3488 0.375
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Echinococcus multilocularis tyrosine protein kinase Srms 0.088 0.9302 0.9302
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0347 0.3495 0.9408
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Echinococcus multilocularis tyrosine kinase 0.088 0.9302 0.9302
Trypanosoma brucei protein kinase, putative 0.0347 0.3495 0.9408
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.1131 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0534 0.5533 0.5948
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Brugia malayi Cytochrome P450 family protein 0.0088 0.0676 0.0726
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Brugia malayi Protein kinase domain containing protein 0.088 0.9302 1
Schistosoma mansoni single-minded 0.005 0.0258 0.0278
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus tyrosine protein kinase Fyn 0.088 0.9302 0.9992
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Entamoeba histolytica tyrosin kinase, putative 0.0346 0.3488 0.3662
Loa Loa (eye worm) serine/threonine protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0067 0.0444 0.0477
Entamoeba histolytica serine/threonine kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis protein patched 0.0049 0.0254 0.0254
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Schistosoma mansoni protein kinase 0.0347 0.3495 0.3757
Echinococcus multilocularis SH2 motif 0.0534 0.5533 0.5533
Echinococcus multilocularis N chimaerin 0.0534 0.5533 0.5533
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Onchocerca volvulus 0.0346 0.3488 0.3669
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus multilocularis insulin receptor 0.0346 0.3488 0.3488
Echinococcus granulosus receptor type guanylyl cyclase 0.0346 0.3488 0.3747
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus kinase suppressor of Ras 1 0.0346 0.3488 0.3747
Trypanosoma brucei C-8 sterol isomerase, putative 0.0367 0.3715 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0534 0.5533 0.5896
Echinococcus multilocularis NCK adaptor protein 0.0534 0.5533 0.5533
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0318 0.0342
Echinococcus granulosus tyrosine protein kinase csk 0.0346 0.3488 0.3747
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0367 0.3715 1
Schistosoma mansoni lozenge 0.0055 0.0318 0.0341
Brugia malayi SRC-1 0.088 0.9302 1
Onchocerca volvulus 0.0534 0.5533 0.5896
Schistosoma mansoni tyrosine kinase 0.088 0.9302 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0346 0.3488 0.9979
Schistosoma mansoni SH2A 0.0534 0.5533 0.5948
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0346 0.3488 0.3747
Brugia malayi Tyrosine-protein kinase PR2 0.0346 0.3488 0.375
Brugia malayi protein-tyrosine kinase 0.088 0.9302 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0346 0.3488 0.375
Brugia malayi hypoxia-induced factor 1 0.0153 0.139 0.1494
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0346 0.3488 0.375
Brugia malayi hypothetical protein 0.0439 0.4494 0.4832
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Echinococcus multilocularis raf serine:threonine protein kinase 0.0346 0.3488 0.3488
Echinococcus granulosus tyrosine protein kinase Fyn 0.088 0.9302 0.9992
Echinococcus granulosus SH2 motif 0.0534 0.5533 0.5943
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0439 0.4494 0.4832
Entamoeba histolytica tyrosin kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis tyrosine protein kinase Fgr 0.088 0.9302 0.9302
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.019 0.1682
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0346 0.3488 0.3488
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0129 0.0347
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus multilocularis protein kinase 0.0346 0.3488 0.3488
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0534 0.5533 0.5896
Toxoplasma gondii STE kinase 0.0346 0.3488 0.9979
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0346 0.3488 0.3488
Giardia lamblia Protein 21.1 0.0346 0.3488 1
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Leishmania major cytochrome p450-like protein 0.0043 0.019 0.0512
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) TK/CSK protein kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0188 0.1761 0.1893
Trypanosoma brucei protein kinase, putative 0.0055 0.0313 0.0843
Echinococcus granulosus N chimaerin 0.0534 0.5533 0.5943
Schistosoma mansoni tensin-related 0.0534 0.5533 0.5948
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0254 0.0273
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Schistosoma mansoni protein kinase 0.0347 0.3495 0.3757
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.088 0.9302 0.9302
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0313 0.0313
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0346 0.3488 0.3488
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Echinococcus granulosus SH2 motif 0.0534 0.5533 0.5943
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.1131 0.1215
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis tyrosine protein kinase 0.0346 0.3488 0.3488
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Schistosoma mansoni ephrin receptor 0.0346 0.3488 0.375
Loa Loa (eye worm) RGC/RGC protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica serine/threonine kinase, putative 0.0346 0.3488 0.3662
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.019 0.0205
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0346 0.3488 0.3669
Loa Loa (eye worm) SRC-1 0.088 0.9302 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0129 0.0139
Schistosoma mansoni signal transduction protein lnk-related 0.0534 0.5533 0.5948
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0534 0.5533 0.5948
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.019 0.0512
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.019 0.0512
Echinococcus granulosus growth factor receptor bound protein 2 0.0534 0.5533 0.5943
Brugia malayi Cytochrome P450 family protein 0.0043 0.019 0.0205
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0534 0.5533 0.5533
Schistosoma mansoni hypothetical protein 0.0346 0.3488 0.375
Schistosoma mansoni tensin-related 0.0534 0.5533 0.5948
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica SH2-protein kinase domain containing protein 0.088 0.9302 1
Plasmodium vivax protein kinase, putative 0.0346 0.3488 0.5
Brugia malayi hypothetical protein 0.0346 0.3488 0.375
Loa Loa (eye worm) TK/DDR protein kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0367 0.3715 0.3994
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus tyrosine protein kinase HCK 0.0346 0.3488 0.3747
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Entamoeba histolytica cysteine surface protein, putative 0.0346 0.3488 0.3662
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.3488 0.375
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Schistosoma mansoni hypothetical protein 0.0047 0.0235 0.0253
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0534 0.5533 0.5948
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0346 0.3488 0.375
Brugia malayi tRNA modification GTPase TrmE family protein 0.0534 0.5533 0.5948
Echinococcus granulosus retinal guanylyl cyclase 2 0.0346 0.3488 0.3747
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.1503 0.1614
Echinococcus multilocularis tensin 0.0534 0.5533 0.5533
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Schistosoma mansoni vav2 0.0534 0.5533 0.5948
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.088 0.9302 0.9302
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus epidermal growth factor receptor 0.0346 0.3488 0.3747
Leishmania major hypothetical protein, conserved 0.0346 0.3488 0.9389
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) hypothetical protein 0.088 0.9302 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0967 0.0913
Onchocerca volvulus 0.088 0.9302 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0346 0.3488 0.3747
Loa Loa (eye worm) hypothetical protein 0.0439 0.4494 0.4832
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus tyrosine protein kinase ABL1 0.088 0.9302 0.9992
Echinococcus granulosus tensin 0.0534 0.5533 0.5943
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0313 0.0337
Brugia malayi Tensin 0.0534 0.5533 0.5948
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0346 0.3488 0.9389
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0346 0.3488 0.9979
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus protein tyrosine kinase 0.0346 0.3488 0.3747
Entamoeba histolytica hypothetical protein 0.0346 0.3489 0.3663
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0346 0.3488 0.3488
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0346 0.3488 0.3488
Brugia malayi Immunoglobulin I-set domain containing protein 0.0346 0.3488 0.375
Echinococcus multilocularis signal transduction protein lnk realted 0.0534 0.5533 0.5533
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0313 0.0548
Echinococcus multilocularis activin receptor type 0.0347 0.3495 0.3495
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0346 0.3488 0.9983
Echinococcus multilocularis tyrosine protein kinase Blk 0.088 0.9302 0.9302
Loa Loa (eye worm) hypothetical protein 0.0115 0.0967 0.1039
Echinococcus multilocularis protein dispatched 1 0.0056 0.033 0.033
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0313 0.0843
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0346 0.3488 0.375
Echinococcus granulosus tyrosine protein kinase Blk 0.088 0.9302 0.9992
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine protein kinase Srms 0.088 0.9302 0.9992
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0367 0.3715 0.3994
Schistosoma mansoni growth factor receptor-bound protein 0.0534 0.5533 0.5948
Trypanosoma brucei cytochrome P450, putative 0.0043 0.019 0.0512
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0346 0.3488 0.3747
Brugia malayi Variant SH3 domain containing protein 0.0534 0.5533 0.5948
Schistosoma mansoni tyrosine kinase 0.088 0.9302 1
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Toxoplasma gondii protein kinase domain-containing protein 0.0346 0.3488 0.9979
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0346 0.3489 0.3663
Echinococcus multilocularis protein KINase family member (kin 25) 0.0346 0.3488 0.3488
Trichomonas vaginalis protein tyrosine kinase, putative 0.0346 0.3488 0.9983
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0534 0.5533 0.5948
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0535 0.554 0.5899
Loa Loa (eye worm) TK/EPH protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus signal transduction protein lnk realted 0.0534 0.5533 0.5943
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica ankyrin repeat protein 0.0346 0.3488 0.3662
Echinococcus multilocularis tyrosine protein kinase csk 0.0346 0.3488 0.3488
Schistosoma mansoni protein kinase 0.0347 0.3495 0.3757
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0129 0.0347
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Plasmodium falciparum protein kinase, putative 0.0347 0.3495 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0534 0.5533 0.5948
Echinococcus multilocularis kinase suppressor of Ras 1 0.0346 0.3488 0.3488
Echinococcus multilocularis ephrin type A receptor 4 A 0.0346 0.3488 0.3488
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.088 0.9302 0.9992
Echinococcus granulosus protein kinase 0.0346 0.3488 0.3747
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Schistosoma mansoni shc transforming protein 0.0534 0.5533 0.5948
Brugia malayi CHE-14 protein 0.0049 0.0254 0.0273
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Brugia malayi Protein kinase domain containing protein 0.088 0.9302 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0347 0.3495 0.9408
Trichomonas vaginalis TK family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0118 0.1045
Entamoeba histolytica serine/threonine kinase, putative 0.0346 0.3488 0.3662
Schistosoma mansoni tensin 0.0534 0.5533 0.5948
Brugia malayi Tyrosine-protein kinase abl-1 0.088 0.9302 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0313 0.0547
Echinococcus multilocularis SHC transforming protein 3 0.0534 0.5533 0.5533
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0346 0.3488 0.3747
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus suppressor of cytokine signaling 7 0.0534 0.5533 0.5943
Loa Loa (eye worm) SH2 domain-containing protein 0.0534 0.5533 0.5948
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine protein kinase shark 0.088 0.9302 0.9992
Brugia malayi integrin-linked kinase 0.0346 0.3488 0.375
Echinococcus granulosus tyrosine protein kinase Src64B 0.088 0.9302 0.9992
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Giardia lamblia Kinase, NEK 0.0346 0.3488 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0254 0.0273
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica tyrosin kinase, putative 0.0346 0.3488 0.3662
Brugia malayi SH2 domain containing protein 0.088 0.9302 1
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus granulosus tyrosine protein kinase Src42A 0.088 0.9302 0.9992
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0129 0.0129
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0534 0.5533 0.5943
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Brugia malayi hypothetical protein 0.0534 0.5533 0.5948
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Schistosoma mansoni patched 1 0.0049 0.0254 0.0273
Toxoplasma gondii protein kinase 0.0346 0.3488 0.9979
Echinococcus granulosus tyrosine protein kinase Fyn 0.088 0.9302 0.9992
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.3488 0.375
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0346 0.3488 0.375
Onchocerca volvulus 0.0534 0.5533 0.5896
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0534 0.5533 0.5948
Brugia malayi cytokine inducible SH2-containing protein 5 0.0534 0.5533 0.5948
Echinococcus granulosus c src tyrosine kinase 0.088 0.9302 0.9992
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0346 0.3488 0.9983
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0347 0.3495 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Brugia malayi STAT protein, DNA binding domain containing protein 0.0534 0.5533 0.5948
Schistosoma mansoni tyrosine kinase 0.088 0.9302 1
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0129 0.0139
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus NCK adaptor protein 0.0534 0.5533 0.5943
Brugia malayi Protein kinase domain containing protein 0.088 0.9302 1
Entamoeba histolytica protein kinase domain containing protein 0.0347 0.3495 0.367
Onchocerca volvulus 0.088 0.9302 1
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus natriuretic peptide receptor 1 0.0346 0.3488 0.3747
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0346 0.3488 0.3488
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0129 0.0129
Giardia lamblia Kinase 0.0346 0.3488 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.1131 0.3044
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0313 0.0843
Loa Loa (eye worm) TK/EGFR protein kinase 0.0346 0.3488 0.375
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0967 0.1039
Echinococcus granulosus SH2 domain containing adapter protein F 0.0534 0.5533 0.5943
Loa Loa (eye worm) runx1 0.0055 0.0318 0.0341
Trypanosoma cruzi protein kinase, putative 0.0346 0.3488 0.9389
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0129 0.0139
Echinococcus multilocularis tyrosine protein kinase shark 0.088 0.9302 0.9302
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.088 0.9302 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.019 0.0205
Schistosoma mansoni tyrosine kinase 0.088 0.9302 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0534 0.5533 0.5948
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0346 0.3488 0.3747
Schistosoma mansoni hypothetical protein 0.0534 0.5533 0.5948
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0347 0.3495 0.9408
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0313 0.0547
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni suppressor of cytokine signaling 0.0534 0.5533 0.5948
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.1131 0.3235
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0346 0.3488 0.375
Schistosoma mansoni serine/threonine RGC 0.0346 0.3488 0.375
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0313 0.0896
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0129 0.0139
Onchocerca volvulus 0.0346 0.3488 0.3669
Echinococcus multilocularis growth factor receptor bound protein 2 0.0534 0.5533 0.5533
Trichomonas vaginalis AGC family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni nck2/grb4 0.0534 0.5533 0.5948
Echinococcus multilocularis epidermal growth factor receptor 0.0346 0.3488 0.3488
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0346 0.3488 0.375
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.088 0.9302 0.9992
Trypanosoma brucei Pseudokinase, putative 0.0346 0.3488 0.9389
Echinococcus multilocularis 0.0534 0.5533 0.5533
Mycobacterium leprae putative cytochrome p450 0.0026 0 0.5
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Mycobacterium leprae Conserved hypothetical protein 0.0026 0 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0534 0.5533 0.5943
Echinococcus granulosus tyrosine protein kinase Src42A 0.0534 0.5533 0.5943
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0346 0.3488 0.3747
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.088 0.9302 1
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0254 0.0273
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0118 0.0118
Loa Loa (eye worm) TK protein kinase 0.088 0.9302 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.088 0.9302 0.9302
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Entamoeba histolytica protein kinase, putative 0.0346 0.3489 0.3663
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni tensin 0.0534 0.5533 0.5948
Loa Loa (eye worm) TK/FAK protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica hypothetical protein, conserved 0.0346 0.3488 0.3662
Entamoeba histolytica receptor protein kinase, putative 0.0346 0.3488 0.3662
Onchocerca volvulus 0.0346 0.3488 0.3669
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Echinococcus granulosus integrin linked protein kinase 0.0346 0.3488 0.3747
Giardia lamblia Kinase, NEK 0.0346 0.3488 1
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Onchocerca volvulus 0.0534 0.5533 0.5896
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus retinal guanylyl cyclase 2 0.0346 0.3488 0.3747
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0118 0.0127
Echinococcus multilocularis tyrosine protein kinase pr2 0.0346 0.3488 0.3488
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.3488 0.375
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0066 0.0439 0.0439
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0534 0.5533 0.5533
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni hypothetical protein 0.0047 0.0235 0.0253
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0066 0.0439 0.0472
Entamoeba histolytica serine/threonine kinase, putative 0.0346 0.3488 0.3662
Onchocerca volvulus 0.0346 0.3488 0.3669
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.1131 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0313 0.0547
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.088 0.9302 0.9302
Brugia malayi Furin-like cysteine rich region family protein 0.0346 0.3488 0.375
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0534 0.5533 0.5533
Echinococcus multilocularis SH2 domain containing protein 7 0.0534 0.5533 0.5533
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0534 0.5533 0.5533
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Echinococcus granulosus retinal guanylyl cyclase 2 0.0346 0.3488 0.3747
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0129 0.0347
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0346 0.3488 0.375
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Schistosoma mansoni growth factor receptor-bound protein 0.0534 0.5533 0.5948
Echinococcus multilocularis tyrosine kinase 0.0346 0.3488 0.3488
Echinococcus granulosus single minded 2 0.0037 0.0118 0.0127
Brugia malayi C-terminal src kinase protein 1 0.0346 0.3488 0.375
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0346 0.3488 0.3669
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis FL cytokine receptor 0.0346 0.3488 0.3488
Entamoeba histolytica hypothetical protein 0.0346 0.3489 0.3663
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi Immunoglobulin I-set domain containing protein 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0967 0.1039
Echinococcus multilocularis tyrosine protein kinase csk 0.0346 0.3488 0.3488
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Onchocerca volvulus 0.0346 0.3488 0.3669
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Loa Loa (eye worm) RGC/RGC protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.1131 0.1216
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) CYP4Cod1 0.0043 0.019 0.0205
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0346 0.3488 0.9983
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Leishmania major C-8 sterol isomerase-like protein 0.0367 0.3715 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0313 0.0547
Brugia malayi hypothetical protein 0.0166 0.153 0.1645
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0346 0.3488 0.375
Echinococcus multilocularis tyrosine protein kinase HCK 0.0346 0.3488 0.3488
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0534 0.5533 0.5948
Echinococcus granulosus tyrosine protein kinase 0.0346 0.3488 0.3747
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0313 0.0843
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0313 0.0336
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0346 0.3488 0.375
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Onchocerca volvulus 0.0346 0.3488 0.3669
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0346 0.3488 0.3747
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Echinococcus multilocularis tyrosine protein kinase csk 0.0346 0.3488 0.3488
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0346 0.3488 0.3488
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Leishmania major protein kinase, putative 0.0346 0.3488 0.9389
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0346 0.3488 0.3747
Schistosoma mansoni protein tyrosine kinase 0.0346 0.3488 0.375
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.088 0.9302 0.9992
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0313 0.0336
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0258 0.0278
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0313 0.0313
Onchocerca volvulus 0.0534 0.5533 0.5896
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Loa Loa (eye worm) RGC/RGC protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0346 0.3488 0.3488
Echinococcus multilocularis epidermal growth factor receptor 0.0346 0.3488 0.3488
Echinococcus multilocularis tyrosine protein kinase csk 0.0346 0.3488 0.3488
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0986 0.106
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.088 0.9302 0.9302
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) TK/ABL protein kinase 0.088 0.9302 1
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0534 0.5533 0.5948
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0346 0.3488 0.3747
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0254 0.0372
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine kinase 0.088 0.9302 0.9992
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0534 0.5533 0.5943
Onchocerca volvulus 0.0346 0.3488 0.3669
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.088 0.9302 0.9302
Echinococcus multilocularis receptor type guanylyl cyclase 0.0346 0.3488 0.3488
Trichomonas vaginalis TKL family protein kinase 0.0347 0.3494 1
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0313 0.0337
Echinococcus granulosus insulin receptor 0.0346 0.3488 0.3747
Echinococcus granulosus epidermal growth factor receptor 0.0346 0.3488 0.3747
Trichomonas vaginalis protein kinase atn1, putative 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0049 0.0254 0.0273
Schistosoma mansoni lipoxygenase 0.0055 0.0318 0.0342
Echinococcus granulosus SHC transforming protein 3 0.0534 0.5533 0.5943
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Echinococcus granulosus fibroblast growth factor receptor 4 0.0346 0.3488 0.3747
Brugia malayi Variant SH3 domain containing protein 0.0534 0.5533 0.5948
Echinococcus granulosus SH2 domain containing protein 7 0.0534 0.5533 0.5943
Echinococcus multilocularis activated cdc42 kinase 1 0.0346 0.3488 0.3488
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0534 0.5533 0.5948
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Brugia malayi Cytochrome P450 family protein 0.0043 0.019 0.0205
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0346 0.3488 0.375
Plasmodium vivax tyrosine kinase-like protein, putative 0.0346 0.3488 0.5
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Onchocerca volvulus 0.0439 0.4494 0.4765
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi SH2 domain containing protein 0.088 0.9302 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0346 0.3488 0.3747
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0346 0.3488 0.3488
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.0676 0.0726
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0346 0.3488 0.3747
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0534 0.5533 0.5948
Trypanosoma cruzi protein kinase, putative 0.0346 0.3488 0.9389
Loa Loa (eye worm) SH2 domain-containing protein 0.0534 0.5533 0.5948
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Brugia malayi Protein kinase domain containing protein 0.088 0.9302 1
Entamoeba histolytica serine/threonine kinase, putative 0.0346 0.3488 0.3662
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.1131 1
Echinococcus multilocularis heat shock protein 70 0.0346 0.3488 0.3488
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0313 0.0843
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0534 0.5533 0.5533
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica hypothetical protein 0.0346 0.3489 0.3663
Loa Loa (eye worm) TK/ROR protein kinase 0.0346 0.3488 0.375
Trypanosoma brucei Flagellum attachment zone protein 20 0.0346 0.3488 0.9389
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.1503 0.1503
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0967 0.0967
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0347 0.3495 0.3754
Entamoeba histolytica hypothetical protein 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine protein kinase Lyn 0.0881 0.9309 1
Brugia malayi hypothetical protein 0.0346 0.3488 0.375
Brugia malayi hypothetical protein 0.088 0.9302 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0346 0.3488 0.3488
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Schistosoma mansoni tyrosine protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.088 0.9302 1
Echinococcus granulosus tyrosine kinase 0.088 0.9302 0.9992
Schistosoma mansoni tensin 0.0534 0.5533 0.5948
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Entamoeba histolytica tyrosin kinase, putative 0.0346 0.3488 0.3662
Entamoeba histolytica serine/threonine kinase, putative 0.0346 0.3488 0.3662
Onchocerca volvulus 0.0346 0.3488 0.3669
Loa Loa (eye worm) hypothetical protein 0.006 0.0375 0.0403
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.139 0.1494
Loa Loa (eye worm) TK/ALK protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica hypothetical protein 0.0347 0.3494 0.3668
Loa Loa (eye worm) STAT protein 0.0534 0.5533 0.5948
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0534 0.5533 0.5943
Brugia malayi Protein kinase domain containing protein 0.0066 0.0439 0.0472
Echinococcus granulosus activin receptor type 0.0347 0.3495 0.3754
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) hypothetical protein 0.0166 0.153 0.1645
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0346 0.3488 0.3662
Schistosoma mansoni suppressor of cytokine signaling 0.0534 0.5533 0.5948
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Onchocerca volvulus 0.088 0.9302 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0534 0.5533 0.5948
Brugia malayi PAS domain containing protein 0.005 0.0258 0.0278
Echinococcus granulosus activated cdc42 kinase 1 0.0346 0.3488 0.3747
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.1131 0.1216
Echinococcus multilocularis tyrosine protein kinase Abl 0.088 0.9302 0.9302
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Brugia malayi Variant SH3 domain containing protein 0.0534 0.5533 0.5948
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi MAP kinase sur-1 0.0055 0.0313 0.0337
Entamoeba histolytica ankyrin repeat protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0139
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Leishmania major protein kinase, putative 0.0347 0.3495 0.9408
Onchocerca volvulus 0.0346 0.3488 0.3669
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Onchocerca volvulus Tyrosine kinase homolog 0.0346 0.3488 0.3669
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Onchocerca volvulus 0.088 0.9302 1
Schistosoma mansoni protein kinase 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0534 0.5533 0.5948
Loa Loa (eye worm) TK/RYK protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus tyrosine protein kinase pr2 0.0346 0.3488 0.3747
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0534 0.5533 0.5943
Brugia malayi Protein kinase domain containing protein 0.088 0.9302 1
Schistosoma mansoni hypothetical protein 0.0047 0.0235 0.0253
Entamoeba histolytica receptor protein kinase, putative 0.0346 0.3488 0.3662
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0346 0.3488 0.375
Echinococcus granulosus activated cdc42 kinase 1 0.0346 0.3488 0.3747
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis protein kinase 0.0346 0.3488 0.3488
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0346 0.3488 0.3488
Echinococcus multilocularis tyrosine protein kinase Fyn 0.088 0.9302 0.9302
Entamoeba histolytica protein kinase, putative 0.0535 0.554 0.5899
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0346 0.3488 0.3488
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0346 0.3488 0.3662
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi Receptor family ligand binding region containing protein 0.0346 0.3488 0.375
Echinococcus multilocularis tyrosine protein kinase Fyn 0.088 0.9302 0.9302
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0318 0.0318
Echinococcus granulosus expressed conserved protein 0.0108 0.0891 0.0957
Loa Loa (eye worm) TK/ACK protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Echinococcus multilocularis Protein lozenge 0.0055 0.0318 0.0318
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0254 0.0254
Echinococcus granulosus tyrosine protein kinase csk 0.0346 0.3488 0.3747
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Echinococcus multilocularis tyrosine protein kinase Src42A 0.088 0.9302 0.9302
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Loa Loa (eye worm) hypothetical protein 0.0346 0.3488 0.375
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0129 0.0347
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0534 0.5533 0.5533
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis transfer RNA-Thr 0.0346 0.3488 0.3488
Loa Loa (eye worm) TK/FER protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.3488 0.3662
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis SH2 motif 0.0534 0.5533 0.5533
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0313 0.0843
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0346 0.3488 0.3488
Brugia malayi Sex muscle abnormal protein 5 0.0534 0.5533 0.5948
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0534 0.5533 0.5533
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus hypothetical protein 0.0534 0.5533 0.5943
Echinococcus granulosus raf serine:threonine protein kinase 0.0346 0.3488 0.3747
Echinococcus multilocularis protein tyrosine kinase 0.0346 0.3488 0.3488
Schistosoma mansoni GTPase activating protein 0.0534 0.5533 0.5948
Onchocerca volvulus 0.088 0.9302 1
Loa Loa (eye worm) TK/Met protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Brugia malayi Variant SH3 domain containing protein 0.0534 0.5533 0.5948
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.3488 0.9983
Echinococcus multilocularis c src tyrosine kinase 0.088 0.9302 0.9302
Schistosoma mansoni hypothetical protein 0.0047 0.0235 0.0253
Loa Loa (eye worm) TK/FER protein kinase 0.088 0.9302 1
Brugia malayi ephrin receptor 1 precursor 0.0346 0.3488 0.375
Trichomonas vaginalis STE family protein kinase 0.0346 0.3488 0.9983
Echinococcus multilocularis integrin linked protein kinase 0.0346 0.3488 0.3488
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Entamoeba histolytica protein kinase, putative 0.0346 0.3488 0.3662
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0129 0.0139
Schistosoma mansoni tyrosine kinase 0.0346 0.3488 0.375
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0313 0.0843
Schistosoma mansoni ephrin receptor 0.0346 0.3488 0.375
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.1131 1
Onchocerca volvulus 0.0534 0.5533 0.5896
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Echinococcus granulosus tyrosine protein kinase csk 0.0346 0.3488 0.3747
Onchocerca volvulus 0.0534 0.5533 0.5896
Brugia malayi Raf kinase 0.0346 0.3488 0.375
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi SH2 domain containing protein 0.0534 0.5533 0.5948
Schistosoma mansoni hypothetical protein 0.0534 0.5533 0.5948
Loa Loa (eye worm) TK/INSR protein kinase 0.0346 0.3488 0.375
Entamoeba histolytica SH2 domain containing protein 0.0534 0.5533 0.5891
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Loa Loa (eye worm) TK protein kinase 0.0346 0.3488 0.375
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0346 0.3488 0.375
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0347 0.3495 0.3495
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983
Brugia malayi Protein kinase domain containing protein 0.0346 0.3488 0.375
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0534 0.5533 0.5533
Entamoeba histolytica tyrosine kinase, putative 0.0346 0.3488 0.3662
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0129 0.0139
Echinococcus multilocularis SH2 motif 0.0534 0.5533 0.5533
Brugia malayi bone morphogenetic protein type 1 receptor 0.0346 0.3488 0.375
Echinococcus multilocularis tyrosine protein kinase Fyn 0.088 0.9302 0.9302
Echinococcus granulosus ephrin type A receptor 4 A 0.0346 0.3488 0.3747
Trichomonas vaginalis TKL family protein kinase 0.0346 0.3488 0.9983

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive/number tested for 3 weeks; 0/5 ChEMBL. 11212120
Activity (functional) = 0 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for trophozoites/number tested for 3 weeks; 0/5 ChEMBL. 11212120
Activity (functional) = 0 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for lesions/number tested for 3 weeks; 0/5 ChEMBL. 11212120
Activity (functional) = 0 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive/number tested for 8 weeks; 4/5 ChEMBL. 11212120
Activity (functional) = 0 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for trophozoites/number tested for 8 weeks; 0/5 ChEMBL. 11212120
Activity (functional) = 0 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of lungs positive for lesions/number tested for 8 weeks; 0/5 ChEMBL. 11212120
Activity (functional) < 1.8 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of cysts/lungs for 3 weeks ChEMBL. 11212120
Activity (functional) = 2.3 Evaluated for inhibitory growth of P. carinii cysts in lungs administered at the dose of 10 mg/kg expressed as number of cysts/lungs for 8 weeks ChEMBL. 11212120
ED50 (functional) = 3 ug ml-1 In vivo effective dose for antifungal activity on sc administration in female mice infected with 2.5*10e6 cells/mL of Candida albicans at day 10 ChEMBL. 11212120
ED50 (functional) = 3.5 ug ml-1 In vivo effective dose for antifungal activity on sc administration in female mice infected with 2.5*10e6 cells/mL of Candida albicans at day 14 ChEMBL. 11212120
IC50 (functional) < 0.003 ug ml-1 In vitro antifungal activity against Aspergillus fumitgatus FD050 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 0.16 ug ml-1 In vitro antifungal activity against Aspergillus niger ATCC9642 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 0.31 ug ml-1 In vitro antifungal activity against Candida albicans FP578 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 0.39 ug ml-1 In vitro antifungal activity against Candida albicans FP582 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 0.47 ug ml-1 In vitro antifungal activity against Candida albicans FP629 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 0.47 ug ml-1 In vitro antifungal activity against Candida albicans FP633 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 0.47 ug ml-1 In vitro antifungal activity against Candida tropicalis YC118 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 1.35 ug ml-1 In vitro antifungal activity against Candida utilis YC123 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) = 1.9 ug ml-1 In vitro antifungal activity against Candida krusei YC109 at 37 degrees C for 22h ChEMBL. 11212120
IC50 (functional) > 2.5 ug ml-1 In vitro antifungal activity against Cryptococcus neoformans YC203 at 30 degrees C for 48 hr ChEMBL. 11212120
IC50 (functional) = 2.8 ug ml-1 Compound was tested for inhibitory activity against 1,3-beta-glucan synthase from Candida albicans 6406 ChEMBL. 11212120
LC30 (functional) > 500 Lytic concentration for hemolytic activity in human by akaishi method ChEMBL. 11212120
MLC (functional) > 500 Minimum lytic concentration that lysed red blood cells in mouse ChEMBL. 11212120
MLC (functional) > 1000 Minimum lytic concentration that lysed red blood cells in human ChEMBL. 11212120

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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