Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1036 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0232 | 1 | 1 |
Plasmodium falciparum | tubulin gamma chain | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.1036 | 0.1036 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0232 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0037 | 0.1036 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0037 | 0.1036 | 0.1036 |
Giardia lamblia | Gamma tubulin | 0.0014 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1036 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.1036 | 0.1036 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1036 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.1036 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0037 | 0.1036 | 0.1036 |
Schistosoma mansoni | nicalin (M28 family) | 0.0037 | 0.1036 | 0.1036 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1036 | 0.1036 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0037 | 0.1036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 1 | 1 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1036 | 0.1036 |
Brugia malayi | nicalin | 0.0037 | 0.1036 | 0.1036 |
Plasmodium falciparum | alpha tubulin 2 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0232 | 1 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0037 | 0.1036 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0037 | 0.1036 | 0.1036 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1036 | 1 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0232 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0014 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0037 | 0.1036 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0037 | 0.1036 | 0.1036 |
Entamoeba histolytica | tubulin gamma chain | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0037 | 0.1036 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.1036 | 0.1036 |
Brugia malayi | FXNA | 0.0037 | 0.1036 | 0.1036 |
Plasmodium falciparum | alpha tubulin 1 | 0.0014 | 0 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1036 | 0.1036 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0.1036 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0037 | 0.1036 | 0.1036 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0037 | 0.1036 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0037 | 0.1036 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.1036 | 0.1036 |
Giardia lamblia | Beta tubulin | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1036 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0037 | 0.1036 | 0.1036 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0037 | 0.1036 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 225 ng ml-1 | Cytotoxicity of the compound against IGROV tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 225 ng ml-1 | Cytotoxicity of the compound against IGROV tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1158 ng ml-1 | Cytotoxicity of the compound against A 498 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1158 ng ml-1 | Cytotoxicity of the compound against A 498 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1195 ng ml-1 | Cytotoxicity of the compound against EVSA-T tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1195 ng ml-1 | Cytotoxicity of the compound against EVSA-T tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1214 ng ml-1 | Cytotoxicity of the compound against MCF-7 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1214 ng ml-1 | Cytotoxicity of the compound against MCF-7 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1578 ng ml-1 | Cytotoxicity of the compound against M19 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1698 ng ml-1 | Cytotoxicity of the compound against H 226 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 1698 ng ml-1 | Cytotoxicity of the compound against H 226 tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 2150 ng ml-1 | Cytotoxicity of the compound against WIDR tumor cell line | ChEMBL. | 10602713 |
ID50 (functional) | = 2150 ng ml-1 | Cytotoxicity of the compound against WIDR tumor cell line | ChEMBL. | 10602713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.