Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0106 | 0.0322 | 0.2864 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0068 | 0.0131 | 0.1169 |
Schistosoma mansoni | Replicative DNA helicase | 0.2043 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0038 | 0.024 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0155 | 0.0566 | 0.209 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0069 | 0.014 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0566 | 0.209 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.0672 | 0.5454 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.1065 | 0.9409 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0038 | 0.024 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.2043 | 1 | 0.5 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0068 | 0.0131 | 0.0094 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0199 | 0.0788 | 0.7013 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0109 | 0.034 | 0.0303 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0094 | 0.0261 | 0.1656 |
Leishmania major | lanosterol synthase, putative | 0.0088 | 0.0232 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0322 | 0.0285 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.2043 | 1 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.2043 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0357 | 0.1576 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0109 | 0.034 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 0.092 | 0.3396 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 0.1123 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.1123 | 0.4145 |
Echinococcus multilocularis | geminin | 0.0357 | 0.1576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0469 | 0.1731 |
Trypanosoma brucei | lanosterol synthase | 0.0117 | 0.0377 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0038 | 0.0337 |
Loa Loa (eye worm) | twinkle helicase | 0.0584 | 0.2709 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 0.1049 | 0.3872 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0117 | 0.0377 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.1065 | 0.9409 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0469 | 0.4175 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0109 | 0.034 | 0.3029 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0094 | 0.0261 | 0.1656 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0068 | 0.0131 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.019 | 0.0745 | 0.6185 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0068 | 0.0131 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0469 | 0.1731 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.1065 | 0.9409 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0069 | 0.014 | 0.0889 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0038 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0038 | 0.014 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.1065 | 0.9409 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0068 | 0.0131 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.1576 | 0.1544 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.0926 | 0.057 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.1065 | 0.9409 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0155 | 0.0566 | 0.5041 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0304 | 0.1121 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0155 | 0.0566 | 0.5041 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.1576 | 0.1544 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0254 | 0.1065 | 0.3929 |
Schistosoma mansoni | transient receptor potential channel | 0.0102 | 0.0304 | 0.0267 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 0.1049 | 0.3872 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0069 | 0.014 | 0.0889 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0254 | 0.1065 | 0.9409 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0254 | 0.1065 | 0.9478 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0117 | 0.0377 | 1 |
Giardia lamblia | Prenyltransferase | 0.0068 | 0.0131 | 0.5 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0102 | 0.0304 | 0.0267 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.2043 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0109 | 0.034 | 0.0303 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0068 | 0.0131 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.2043 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0038 | 0.024 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.0627 | 0.5002 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0109 | 0.034 | 0.2106 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0109 | 0.034 | 0.1256 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0322 | 0.1187 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0102 | 0.0304 | 0.1928 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.1123 | 0.1089 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0038 | 0.024 |
Brugia malayi | MH2 domain containing protein | 0.0251 | 0.1049 | 0.9341 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0038 | 0.0337 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.1123 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0788 | 0.2907 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0102 | 0.0304 | 0.1928 |
Schistosoma mansoni | transient receptor potential channel | 0.0069 | 0.014 | 0.0103 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.0672 | 0.5454 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0109 | 0.034 | 0.2159 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0038 | 0.024 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.1123 | 0.4145 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0097 | 0.0359 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0068 | 0.0131 | 0.0833 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0068 | 0.0131 | 0.0485 |
Brugia malayi | follicle stimulating hormone receptor | 0.0226 | 0.092 | 0.8192 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0109 | 0.034 | 0.2159 |
Schistosoma mansoni | transient receptor potential channel | 0.0069 | 0.014 | 0.0103 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0038 | 0.014 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0069 | 0.014 | 0.0889 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0167 | 0.0627 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Efficacy against Pgp+ human colon tumor xenograft DLD1 in SCID mice at 75 mg/kg, iv | ChEMBL. | 16298526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.