Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.1314 | 0.8599 | 0.8599 |
Echinococcus multilocularis | caspase | 0.1314 | 0.8599 | 0.8599 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0124 | 0.0153 | 0.0248 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0114 | 0.0087 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.065 | 0.3888 | 0.3888 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0968 | 0.6145 | 0.6145 |
Trichomonas vaginalis | conserved hypothetical protein | 0.065 | 0.3888 | 0.6327 |
Echinococcus multilocularis | caspase 2 | 0.1511 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0968 | 0.6145 | 0.6145 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Plasmodium vivax | vivapain-2 | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0114 | 0.0087 | 0.0087 |
Echinococcus multilocularis | cysteine protease | 0.0124 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | cysteine protease | 0.0124 | 0.0153 | 0.0153 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0968 | 0.6145 | 0.6145 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.0153 | 0.0153 |
Echinococcus granulosus | caspase 2 | 0.1511 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.1314 | 0.8599 | 0.8599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0114 | 0.0087 | 0.0141 |
Trypanosoma cruzi | metacaspase 5, putative | 0.065 | 0.3888 | 0.6327 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Leishmania major | metacaspase, putative | 0.065 | 0.3888 | 0.6327 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.065 | 0.3888 | 0.3888 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0303 | 0.1428 | 0.1428 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0968 | 0.6145 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0968 | 0.6145 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.1314 | 0.8599 | 0.8599 |
Echinococcus multilocularis | caspase 8 | 0.065 | 0.3888 | 0.3888 |
Loa Loa (eye worm) | fibroinase | 0.0124 | 0.0153 | 0.0153 |
Toxoplasma gondii | cathepsin B | 0.0114 | 0.0087 | 0.0141 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.065 | 0.3888 | 0.6327 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Echinococcus granulosus | cathepsin b | 0.0303 | 0.1428 | 0.1428 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0303 | 0.1428 | 0.2324 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0124 | 0.0153 | 0.0153 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.065 | 0.3888 | 0.6327 |
Echinococcus granulosus | cathepsin l1 | 0.0124 | 0.0153 | 0.0153 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.1314 | 0.8599 | 0.8599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.0153 | 0.0153 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.065 | 0.3888 | 0.3888 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0124 | 0.0153 | 0.0153 |
Brugia malayi | hypothetical protein | 0.0243 | 0.0998 | 0.0998 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.065 | 0.3888 | 0.6327 |
Trypanosoma cruzi | metacaspase, putative | 0.065 | 0.3888 | 0.6327 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Giardia lamblia | Cathepsin B precursor | 0.0114 | 0.0087 | 0.0141 |
Echinococcus multilocularis | caspase 3 | 0.0664 | 0.3987 | 0.3987 |
Echinococcus granulosus | caspase | 0.1314 | 0.8599 | 0.8599 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0124 | 0.0153 | 0.0153 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Loa Loa (eye worm) | cathepsin B | 0.0114 | 0.0087 | 0.0087 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma brucei | metacaspase MCA3 | 0.065 | 0.3888 | 0.6327 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.065 | 0.3888 | 0.6327 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.065 | 0.3888 | 0.6327 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0114 | 0.0087 | 0.0141 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0124 | 0.0153 | 0.0153 |
Plasmodium falciparum | metacaspase-like protein | 0.065 | 0.3888 | 0.6327 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.0153 | 0.0153 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0968 | 0.6145 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0968 | 0.6145 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0998 | 0.0998 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Mycobacterium ulcerans | proteasome PrcB | 0.0968 | 0.6145 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Echinococcus multilocularis | cathepsin b | 0.0303 | 0.1428 | 0.1428 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0124 | 0.0153 | 0.0248 |
Plasmodium vivax | hypothetical protein, conserved | 0.065 | 0.3888 | 0.6327 |
Trypanosoma brucei | metacaspase 5, putative | 0.065 | 0.3888 | 0.6327 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0124 | 0.0153 | 0.0153 |
Echinococcus granulosus | caspase 8 | 0.065 | 0.3888 | 0.3888 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0303 | 0.1428 | 0.1428 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0243 | 0.0998 | 0.0998 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.1428 | 0.1428 |
Giardia lamblia | Cathepsin B precursor | 0.0114 | 0.0087 | 0.0141 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0124 | 0.0153 | 0.0153 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0968 | 0.6145 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0714 | 0.4343 | 0.4343 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0124 | 0.0153 | 0.0248 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0124 | 0.0153 | 0.0248 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Echinococcus granulosus | proteasome prosome macropain | 0.0968 | 0.6145 | 0.6145 |
Echinococcus multilocularis | cathepsin b | 0.0303 | 0.1428 | 0.1428 |
Trypanosoma cruzi | metacaspase, putative | 0.065 | 0.3888 | 0.6327 |
Brugia malayi | hypothetical protein | 0.0714 | 0.4343 | 0.4343 |
Trypanosoma cruzi | metacaspase 5, putative | 0.065 | 0.3888 | 0.6327 |
Trypanosoma cruzi | metacaspase, putative | 0.065 | 0.3888 | 0.6327 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0968 | 0.6145 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0124 | 0.0153 | 0.0153 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0968 | 0.6145 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.1511 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.0153 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0714 | 0.4343 | 0.4343 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0968 | 0.6145 | 0.5 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0968 | 0.6145 | 0.6145 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0124 | 0.0153 | 0.0153 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0968 | 0.6145 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma brucei | Metacaspase-4 | 0.065 | 0.3888 | 0.6327 |
Plasmodium vivax | metacaspase 1, putative | 0.065 | 0.3888 | 0.6327 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0968 | 0.6145 | 1 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.0153 | 0.0153 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.0153 | 0.0248 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0124 | 0.0153 | 0.0153 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.065 | 0.3888 | 0.6327 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0303 | 0.1428 | 0.1428 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.1511 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0124 | 0.0153 | 0.0248 |
Giardia lamblia | Cathepsin B precursor | 0.0114 | 0.0087 | 0.0141 |
Plasmodium falciparum | metacaspase 1 | 0.065 | 0.3888 | 0.6327 |
Trypanosoma brucei | metacaspase | 0.065 | 0.3888 | 0.6327 |
Loa Loa (eye worm) | hypothetical protein | 0.1511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0153 | 0.0153 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0968 | 0.6145 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0714 | 0.4343 | 0.4343 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0124 | 0.0153 | 0.0248 |
Onchocerca volvulus | 0.0714 | 0.4343 | 0.4255 | |
Toxoplasma gondii | cathepsin CPL | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma cruzi | metacaspase, putative | 0.065 | 0.3888 | 0.6327 |
Loa Loa (eye worm) | ctsf protein | 0.0124 | 0.0153 | 0.0153 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0303 | 0.1428 | 0.1428 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0303 | 0.1428 | 0.1428 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.065 | 0.3888 | 0.6327 |
Leishmania major | cathepsin L-like protease | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.065 | 0.3888 | 0.6327 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0243 | 0.0998 | 0.0998 |
Entamoeba histolytica | cysteine protease, putative | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.0153 | 0.0248 |
Plasmodium vivax | vivapain-2 | 0.0124 | 0.0153 | 0.0248 |
Echinococcus granulosus | caspase 3 | 0.0664 | 0.3987 | 0.3987 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Brugia malayi | Cathepsin L-like precursor | 0.0124 | 0.0153 | 0.0153 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0714 | 0.4343 | 0.4343 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0124 | 0.0153 | 0.0153 |
Trypanosoma brucei | metacaspase MCA2 | 0.065 | 0.3888 | 0.6327 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0124 | 0.0153 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0114 | 0.0087 | 0.0141 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0124 | 0.0153 | 0.0153 |
Echinococcus granulosus | cathepsin b | 0.0303 | 0.1428 | 0.1428 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.065 | 0.3888 | 0.6327 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0968 | 0.6145 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0124 | 0.0153 | 0.0248 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0124 | 0.0153 | 0.0153 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 uM | Inhibition of recombinant HIV integrase strand transfer activity | ChEMBL. | 16908139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.