Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0422 | 0.0422 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0038 | 0.0422 | 0.0669 |
Brugia malayi | leucyl aminopeptidase | 0.0038 | 0.0422 | 0.774 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0038 | 0.0422 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0038 | 0.0422 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0038 | 0.0422 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0441 | 0.0441 |
Onchocerca volvulus | 0.0038 | 0.0422 | 1 | |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0038 | 0.0422 | 0.0422 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0038 | 0.0422 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0038 | 0.0422 | 1 |
Brugia malayi | nicalin | 0.0038 | 0.0422 | 0.774 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0051 | 0.0666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0422 | 0.0422 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0038 | 0.0422 | 0.774 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.6553 | 0.6553 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0038 | 0.0422 | 0.0433 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0494 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0038 | 0.0422 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0546 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0422 | 0.0422 |
Brugia malayi | Peptidase family M28 containing protein | 0.0038 | 0.0422 | 0.774 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0546 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0422 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0546 | 0.0546 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0038 | 0.0422 | 0.774 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0038 | 0.0422 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.037 | 0.6309 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0038 | 0.0422 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0038 | 0.0422 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0051 | 0.0666 | 1 |
Brugia malayi | FXNA | 0.0038 | 0.0422 | 0.774 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.909 | 0.909 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0618 | 0.098 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0038 | 0.0422 | 0.0669 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0038 | 0.0422 | 0.0433 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0564 | 0.9756 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0038 | 0.0422 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0546 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0038 | 0.0422 | 0.774 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0038 | 0.0422 | 0.0669 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0494 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0038 | 0.0422 | 0.0669 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0618 | 0.098 |
Leishmania major | glutaminyl cyclase, putative | 0.0038 | 0.0422 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10 uM | Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells | ChEMBL. | 16931010 |
Ki (binding) | > 10 uM | Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells | ChEMBL. | 16931010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.