Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.0357 | 0.0357 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0018 | 0.0018 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0031 | 0.0031 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0031 | 0.0385 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0018 | 0.0018 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.0357 | 0.0357 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0016 | 0.0016 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0031 | 0.0031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.0357 | 0.0357 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0069 | 0.0207 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.0357 | 0.0357 |
Brugia malayi | Matrixin family protein | 0.1065 | 0.283 | 0.9067 |
Brugia malayi | RNA binding protein | 0.0142 | 0.0357 | 0.113 |
Brugia malayi | Matrixin family protein | 0.044 | 0.1156 | 0.3696 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1173 | 0.3121 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.0357 | 0.0357 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1173 | 0.3121 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.1156 | 0.3696 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0111 | 0.0111 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0536 | 0.1413 | 0.4521 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.002 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0189 | 0.0189 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0005 | 0.0001 |
Onchocerca volvulus | 0.0625 | 0.165 | 0.5279 | |
Brugia malayi | Hemopexin family protein | 0.0625 | 0.165 | 0.5279 |
Echinococcus granulosus | dnaJ subfamily B | 0.045 | 0.1182 | 0.1182 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0018 | 0.0018 |
Onchocerca volvulus | 0.0032 | 0.006 | 0.0179 | |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1173 | 0.3121 | 0.3121 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0065 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.0475 | 0.0475 |
Brugia malayi | Pre-SET motif family protein | 0.0239 | 0.0616 | 0.1962 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.0357 | 0.113 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0011 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0272 | 0.0704 | 0.2245 | |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0031 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0536 | 0.1413 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0068 | 0.0068 |
Brugia malayi | Matrixin family protein | 0.044 | 0.1156 | 0.3696 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0065 | 0.0065 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0977 | 0.2594 | 0.831 |
Loa Loa (eye worm) | matrixin family protein | 0.0977 | 0.2594 | 0.831 |
Trichomonas vaginalis | set domain proteins, putative | 0.0272 | 0.0704 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0031 | 0.1999 |
Chlamydia trachomatis | SWIB complex protein | 0.0011 | 0.0005 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0058 | 0.0173 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0005 | 0.0005 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0536 | 0.1413 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0111 | 0.0111 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0069 | 0.0069 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0111 | 0.0343 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0189 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0011 | 0.0005 | 0.0005 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0893 | 0.2369 | 0.2369 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0031 | 0.0385 |
Onchocerca volvulus | 0.044 | 0.1156 | 0.3696 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0111 | 0.0111 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0018 | 0.0018 |
Brugia malayi | Matrixin family protein | 0.044 | 0.1156 | 0.3696 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0189 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0058 | 0.0058 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0031 | 0.418 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.1156 | 0.3696 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0069 | 0.4782 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0005 | 0.0005 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0031 | 0.0087 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.0357 | 0.0357 |
Schistosoma mansoni | microtubule-associated protein tau | 0.374 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0058 | 0.0173 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0011 | 0.0005 | 0.0005 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0011 | 0.0005 | 0.0005 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0069 | 0.0069 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1173 | 0.3121 | 0.3121 |
Echinococcus multilocularis | dnaJ subfamily B | 0.045 | 0.1182 | 0.1182 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0058 | 0.0058 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0018 | 0.0018 |
Echinococcus multilocularis | geminin | 0.0186 | 0.0475 | 0.0475 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.044 | 0.1156 | 0.3696 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0018 | 0.0018 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.0189 | 0.0189 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0065 | 0.0065 |
Schistosoma mansoni | brg-1 associated factor | 0.0011 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0069 | 0.0207 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.011 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0031 | 0.0058 | 0.0173 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0111 | 0.0111 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.0357 | 0.113 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0018 | 0.0044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.0357 | 0.0357 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0058 | 0.0173 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.044 | 0.1156 | 0.1156 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0018 | 0.0044 |
Schistosoma mansoni | lamin | 0.0031 | 0.0058 | 0.0058 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0189 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1173 | 0.3121 | 0.3121 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.1156 | 0.3696 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0069 | 0.0069 |
Onchocerca volvulus | 0.0035 | 0.0069 | 0.0207 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.0357 | 0.113 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0005 | 0.0005 |
Schistosoma mansoni | lamin | 0.0031 | 0.0058 | 0.0058 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0058 | 0.0058 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0068 | 0.0203 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.0189 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0058 | 0.0173 |
Onchocerca volvulus | 0.0031 | 0.0058 | 0.0173 | |
Chlamydia trachomatis | DNA topoisomerase I | 0.0011 | 0.0005 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0111 | 0.0343 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0014 | 0.003 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.0139 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0031 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0031 | 0.0087 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0069 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.0159 | 0.0159 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0011 | 0.0005 | 0.0005 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0058 | 0.0058 |
Schistosoma mansoni | hypothetical protein | 0.0625 | 0.165 | 0.165 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0031 | 0.0031 |
Echinococcus granulosus | lamin | 0.0031 | 0.0058 | 0.0058 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0031 | 0.0031 |
Echinococcus granulosus | geminin | 0.0186 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0239 | 0.0616 | 0.1962 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0014 | 0.003 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.0357 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0536 | 0.1413 | 0.4521 |
Brugia malayi | Matrixin family protein | 0.044 | 0.1156 | 0.3696 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0031 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.006 | 0.0179 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.0189 | 0.0189 |
Schistosoma mansoni | hypothetical protein | 0.045 | 0.1182 | 0.1182 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0011 | 0.0005 | 0.0005 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1601 | 0.4268 | 0.4268 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.374 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0069 | 0.0069 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0189 | 0.0591 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.006 | 0.0179 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.0357 | 0.113 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0005 | 0.0002 |
Loa Loa (eye worm) | matrixin family protein | 0.1065 | 0.283 | 0.9067 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0057 | 0.0168 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0005 | 0.0005 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.0189 | 0.0189 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1601 | 0.4268 | 0.4268 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0018 | 0.0018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0111 | 0.0111 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0018 | 0.0044 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0031 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0031 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1173 | 0.3121 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0058 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.011 | 0.0339 |
Onchocerca volvulus | Matrilysin homolog | 0.0977 | 0.2594 | 0.831 |
Onchocerca volvulus | Matrilysin homolog | 0.044 | 0.1156 | 0.3696 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.006 | 0.006 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0058 | 0.0058 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.002 | 0.0049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0111 | 0.0111 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.011 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0018 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0016 | 0.0035 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0068 | 0.0203 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0536 | 0.1413 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.011 | 0.0339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 mM | Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay | ChEMBL. | 22940450 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human HL60 cell line by MTT assay | ChEMBL. | 17243725 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human KATO3 cell line by MTT assay | ChEMBL. | 17243725 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human A549 cell line by MTT assay | ChEMBL. | 17243725 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human HL60 cell line by MTT assay | ChEMBL. | 17243725 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human A549 cell line by MTT assay | ChEMBL. | 17243725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.