Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | cathepsin b | 0.015 | 0.1027 | 0.1027 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0879 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Trypanosoma brucei | metacaspase 5, putative | 0.0155 | 0.1089 | 0.1089 |
Loa Loa (eye worm) | cysteine protease | 0.0072 | 0.0076 | 0.0076 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0072 | 0.0076 | 0.0076 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.015 | 0.1027 | 0.1027 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Brugia malayi | Cathepsin L-like precursor | 0.0072 | 0.0076 | 0.0076 |
Leishmania major | metacaspase, putative | 0.0155 | 0.1089 | 0.1089 |
Echinococcus multilocularis | cysteine protease | 0.0072 | 0.0076 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.1156 | 0.1156 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.016 | 0.1156 | 0.1156 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | Metacaspase-4 | 0.0155 | 0.1089 | 0.1089 |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0879 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0879 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Brugia malayi | Cathepsin L-like precursor | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | cathepsin l1 | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.015 | 0.1027 | 0.1027 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0226 | 0.1959 | 0.1959 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Brugia malayi | Cathepsin L-like precursor | 0.0072 | 0.0076 | 0.0076 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0072 | 0.0076 | 0.0076 |
Brugia malayi | Cathepsin L-like precursor | 0.0072 | 0.0076 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1156 | 0.1156 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.015 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.015 | 0.1027 | 0.1027 |
Echinococcus multilocularis | caspase 3 | 0.0071 | 0.0055 | 0.0055 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | Cathepsin L homolog | 0.0072 | 0.0076 | 0.0247 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma cruzi | metacaspase, putative | 0.0155 | 0.1089 | 0.1089 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0072 | 0.0076 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | Cathepsin L homolog | 0.0072 | 0.0076 | 0.0247 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Echinococcus multilocularis | cathepsin b | 0.015 | 0.1027 | 0.1027 |
Echinococcus multilocularis | caspase | 0.0226 | 0.1959 | 0.1959 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0315 | 0.306 | 1 |
Brugia malayi | hypothetical protein | 0.016 | 0.1156 | 0.1156 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Brugia malayi | Cathepsin L-like precursor | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | 0.016 | 0.1156 | 0.3777 | |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0226 | 0.1959 | 0.1959 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0879 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0072 | 0.0076 | 0.0076 |
Echinococcus multilocularis | cathepsin b | 0.015 | 0.1027 | 0.1027 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0879 | 1 | 1 |
Trypanosoma brucei | metacaspase | 0.0155 | 0.1089 | 0.1089 |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | caspase | 0.0226 | 0.1959 | 0.1959 |
Trypanosoma cruzi | metacaspase, putative | 0.0155 | 0.1089 | 0.1089 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.016 | 0.1156 | 0.1156 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0879 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0072 | 0.0076 | 0.0076 |
Toxoplasma gondii | cathepsin CPL | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Trypanosoma cruzi | metacaspase, putative | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Echinococcus multilocularis | caspase 2 | 0.0315 | 0.306 | 0.306 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0879 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0879 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0072 | 0.0076 | 0.0076 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0072 | 0.0076 | 0.0076 |
Plasmodium vivax | metacaspase 1, putative | 0.0155 | 0.1089 | 0.1089 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.015 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | caspase 3 | 0.0071 | 0.0055 | 0.0055 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Loa Loa (eye worm) | fibroinase | 0.0072 | 0.0076 | 0.0076 |
Brugia malayi | Cathepsin L-like precursor | 0.0072 | 0.0076 | 0.0076 |
Plasmodium falciparum | metacaspase-like protein | 0.0155 | 0.1089 | 0.1089 |
Brugia malayi | Cell death protein 3 precursor | 0.0315 | 0.306 | 0.306 |
Leishmania major | cysteine peptidase A (CPA) | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0155 | 0.1089 | 0.1089 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0315 | 0.306 | 0.306 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.015 | 0.1027 | 0.1027 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0226 | 0.1959 | 0.1959 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Onchocerca volvulus | Cathepsin F homolog | 0.0072 | 0.0076 | 0.0247 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Echinococcus multilocularis | caspase 8 | 0.0155 | 0.1089 | 0.1089 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0879 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Plasmodium vivax | hypothetical protein, conserved | 0.0155 | 0.1089 | 0.1089 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0879 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0879 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0226 | 0.1959 | 0.1959 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | proteasome prosome macropain | 0.0879 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0879 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0072 | 0.0076 | 0.0076 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma cruzi | metacaspase, putative | 0.0155 | 0.1089 | 0.1089 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0879 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.306 | 0.306 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Plasmodium falciparum | metacaspase 1 | 0.0155 | 0.1089 | 0.1089 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | metacaspase MCA3 | 0.0155 | 0.1089 | 0.1089 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0076 | 0.0076 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0879 | 1 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0155 | 0.1089 | 0.1089 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1027 | 0.1027 |
Echinococcus granulosus | caspase 2 | 0.0315 | 0.306 | 0.306 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0879 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0072 | 0.0076 | 0.0076 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0155 | 0.1089 | 0.1089 |
Loa Loa (eye worm) | ctsf protein | 0.0072 | 0.0076 | 0.0076 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0155 | 0.1089 | 0.1089 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | metacaspase MCA2 | 0.0155 | 0.1089 | 0.1089 |
Plasmodium vivax | vivapain-2 | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0072 | 0.0076 | 0.0076 |
Echinococcus multilocularis | cysteine protease | 0.0072 | 0.0076 | 0.0076 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0879 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Entamoeba histolytica | cysteine protease, putative | 0.0072 | 0.0076 | 0.0076 |
Echinococcus granulosus | cathepsin b | 0.015 | 0.1027 | 0.1027 |
Onchocerca volvulus | 0.0072 | 0.0076 | 0.0247 | |
Echinococcus granulosus | caspase 8 | 0.0155 | 0.1089 | 0.1089 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0072 | 0.0076 | 0.0076 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0066 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0076 | 0.0076 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.1089 | 0.1089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 98 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 10 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 98 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 10 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 104 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 0.1 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 104 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 0.1 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 107 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 1 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 107 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 1 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 111 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 0.01 uM relative to control | ChEMBL. | 16931014 |
Activity (functional) | = 111 % | Activity at human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation in presence of CPA at 0.01 uM relative to control | ChEMBL. | 16931014 |
Inhibition (binding) | = 0 % | Displacement of [3H]ZM 241385 from human adenosine A2 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16931014 |
Inhibition (binding) | = 0 % | Displacement of [3H]MRE-3008F20 from human adenosine A3 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16931014 |
Inhibition (binding) | = 0 % | Displacement of [3H]ZM 241385 from human adenosine A2 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16931014 |
Inhibition (binding) | = 0 % | Displacement of [3H]MRE-3008F20 from human adenosine A3 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16931014 |
Inhibition (binding) | = 35 % | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16931014 |
Inhibition (binding) | = 35 % | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16931014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.