Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0066 | 0.3029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0066 | 0.3029 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3029 | 0.3029 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0199 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0066 | 0.3029 | 1 |
Onchocerca volvulus | 0.0066 | 0.3029 | 1 | |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0066 | 0.3029 | 0.3029 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0066 | 0.3029 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0199 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0199 | 1 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0066 | 0.3029 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0066 | 0.3029 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0066 | 0.3029 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0199 | 1 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.0066 | 0.3029 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0199 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0199 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0199 | 1 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0199 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3029 | 0.3029 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0066 | 0.3029 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0199 | 1 | 1 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0066 | 0.3029 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0066 | 0.3029 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Antiviral activity against HIV1 in MT4 cells | ChEMBL. | 17188402 |
EC50 (functional) | > 100 uM | Antiviral activity against HSV1 in CCL81 cells | ChEMBL. | 17188402 |
EC50 (functional) | > 100 uM | Antiviral activity against HSV2 in CCL81 cells | ChEMBL. | 17188402 |
EC50 (functional) | > 100 uM | Antiviral activity against HCMV AD169 | ChEMBL. | 17188402 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.