Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0116 | 0.0767 | 0.2072 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0077 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.0767 | 1 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase (NAD+) dependent | 0.008 | 0.0207 | 0.0131 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0116 | 0.0767 | 0.0695 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0116 | 0.0767 | 0.1903 |
Echinococcus multilocularis | Fatty aldehyde dehydrogenase | 0.008 | 0.0207 | 0.0559 |
Onchocerca volvulus | 0.0116 | 0.0767 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase (NAD+) dependent | 0.008 | 0.0207 | 0.0131 |
Brugia malayi | Carboxylesterase family protein | 0.0116 | 0.0767 | 0.1603 |
Trypanosoma cruzi | aldehyde dehydrogenase family, putative | 0.008 | 0.0207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Echinococcus multilocularis | aldehyde dehydrogenase family 3 member B1 | 0.008 | 0.0207 | 0.0559 |
Brugia malayi | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Loa Loa (eye worm) | carboxylesterase | 0.0308 | 0.3701 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2461 | 0.2402 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0116 | 0.0767 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.3701 | 1 |
Onchocerca volvulus | 0.0116 | 0.0767 | 1 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0.1141 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0719 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0116 | 0.0767 | 0.0695 |
Onchocerca volvulus | 0.0116 | 0.0767 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0308 | 0.3701 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0288 | 0.3402 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0116 | 0.0767 | 0.1903 |
Echinococcus multilocularis | acetylcholinesterase | 0.0308 | 0.3701 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0116 | 0.0767 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0116 | 0.0767 | 0.1903 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0116 | 0.0767 | 0.1903 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0116 | 0.0767 | 0.1753 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0116 | 0.0767 | 0.2072 |
Brugia malayi | Carboxylesterase family protein | 0.0308 | 0.3701 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0116 | 0.0767 | 0.1603 |
Trypanosoma cruzi | aldehyde dehydrogenase family, putative | 0.008 | 0.0207 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0116 | 0.0767 | 0.1903 |
Echinococcus granulosus | neuroligin | 0.0116 | 0.0767 | 0.2072 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0288 | 0.3402 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0116 | 0.0767 | 0.1903 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.008 | 0.0207 | 0.0357 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0116 | 0.0767 | 0.2072 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0308 | 0.3701 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Onchocerca volvulus | 0.0116 | 0.0767 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0.1141 | 0.1072 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0308 | 0.3701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0116 | 0.0767 | 0.1603 |
Echinococcus granulosus | Fatty aldehyde dehydrogenase | 0.008 | 0.0207 | 0.0559 |
Brugia malayi | Carboxylesterase family protein | 0.0116 | 0.0767 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.3701 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.0077 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0116 | 0.0767 | 0.2072 |
Echinococcus multilocularis | acetylcholinesterase | 0.0308 | 0.3701 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0308 | 0.3701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Echinococcus granulosus | acetylcholinesterase | 0.0308 | 0.3701 | 1 |
Echinococcus multilocularis | neuroligin | 0.0116 | 0.0767 | 0.2072 |
Echinococcus granulosus | acetylcholinesterase | 0.0308 | 0.3701 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 0.3402 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0.1141 | 0.1072 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0116 | 0.0767 | 0.2072 |
Echinococcus granulosus | carboxylesterase 5A | 0.0308 | 0.3701 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0077 | 0.0209 |
Echinococcus granulosus | aldehyde dehydrogenase family 3 member B1 | 0.008 | 0.0207 | 0.0559 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0116 | 0.0767 | 0.1753 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0767 | 0.1603 |
Schistosoma mansoni | acetylcholinesterase | 0.0116 | 0.0767 | 0.1903 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0077 | 0.0209 |
Trypanosoma brucei | aldehyde dehydrogenase family, putative | 0.008 | 0.0207 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0116 | 0.0767 | 0.2072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Pseudomonas fluorescens after 24 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Staphylococcus aureus after 24 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | = 48.6 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | = 48.6 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | > 50 ug ml-1 | Antibacterial activity against Bacillus subtilis after 24 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Aspergillus niger after 48 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Trichophyton rubrum after 48 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by MTT colorimetric method | ChEMBL. | 17194508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.