Detailed information for compound 432114

Basic information

Technical information
  • TDR Targets ID: 432114
  • Name: 2-[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methyl carbamoyl]-4-oxochromen-7-yl]oxyethyl]anilino ]-2-oxoacetic acid
  • MW: 532.498 | Formula: C28H24N2O9
  • H donors: 4 H acceptors: 6 LogP: 3.76 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)CNC(=O)c1cc(=O)c2c(o1)cc(cc2O)OCCc1ccc(cc1)NC(=O)C(=O)O
  • InChi: 1S/C28H24N2O9/c1-37-19-8-4-17(5-9-19)15-29-26(33)24-14-22(32)25-21(31)12-20(13-23(25)39-24)38-11-10-16-2-6-18(7-3-16)30-27(34)28(35)36/h2-9,12-14,31H,10-11,15H2,1H3,(H,29,33)(H,30,34)(H,35,36)
  • InChiKey: PEWNPFQOJLWZAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]anilino]-2-oxo-acetic acid
  • 2-[4-[2-[[5-hydroxy-2-[[(4-methoxyphenyl)methylamino]-oxomethyl]-4-oxo-1-benzopyran-7-yl]oxy]ethyl]anilino]-2-oxoacetic acid
  • 2-[[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]phenyl]amino]-2-oxo-ethanoic acid
  • 2-[4-[2-[5-hydroxy-4-keto-2-(p-anisylcarbamoyl)chromen-7-yl]oxyethyl]anilino]-2-keto-acetic acid
  • 2-[[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxochromen-7-yl]oxyethyl]phenyl]amino]-2-oxoacetic acid
  • 2-[[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]phenyl]amino]-2-oxo-acetic acid
  • 2-[[4-[2-[[5-hydroxy-2-[[(4-methoxyphenyl)methylamino]-oxomethyl]-4-oxo-7-chromenyl]oxy]ethyl]phenyl]amino]-2-oxoacetic acid
  • 2-[[4-[2-[5-hydroxy-4-keto-2-[(4-methoxybenzyl)carbamoyl]chromen-7-yl]oxyethyl]phenyl]amino]-2-keto-acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Malate dehydrogenase cytoplasmic Starlite/ChEMBL References
Sus scrofa Malate dehydrogenase mitochondrial Starlite/ChEMBL References
Plasmodium falciparum malate dehydrogenase Starlite/ChEMBL References
Plasmodium falciparum L-lactate dehydrogenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania donovani cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania major malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Loa Loa (eye worm) malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania mexicana malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma cruzi cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis L lactate dehydrogenase B chain Get druggable targets OG5_126911 All targets in OG5_126911
Toxoplasma gondii lactate dehydrogenase LDH1 Get druggable targets OG5_126911 All targets in OG5_126911
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma cruzi malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Candida albicans similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Plasmodium yoelii l-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Trypanosoma brucei gambiense mitochondrial malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis L lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Toxoplasma gondii lactate dehydrogenase LDH2 Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania mexicana malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Cryptosporidium parvum malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Brugia malayi lactate dehydrogenase. Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania infantum mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania donovani malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus L lactate dehydrogenase B chain Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania major malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania major mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma brucei mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium yoelii malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania mexicana malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Trypanosoma brucei cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Trypanosoma congolense mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania infantum malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus lactate dehydrogenase protein Get druggable targets OG5_126911 All targets in OG5_126911
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative Get druggable targets OG5_127145 All targets in OG5_127145
Plasmodium falciparum L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium berghei malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Giardia lamblia Malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma brucei gambiense cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium knowlesi L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Neospora caninum Malate dehydrogenase (EC 1.1.1.37), related Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium falciparum malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Trypanosoma cruzi glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania major glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Cryptosporidium hominis malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Entamoeba histolytica malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma japonicum L-lactate dehydrogenase A chain, putative Get druggable targets OG5_126911 All targets in OG5_126911
Cryptosporidium parvum lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Trypanosoma congolense glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania infantum glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma congolense cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma japonicum ko:K00016 L-lactate dehydrogenase [EC1.1.1.27], putative Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania donovani mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans similar to all three S. cerevisiae malate dehydrogenases (YKL085W, YDL078C, YOL126C) Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium vivax lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania donovani glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania infantum cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Theileria parva L-lactate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Schistosoma japonicum ko:K00016 L-lactate dehydrogenase [EC1.1.1.27], putative Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania major cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Candida albicans similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania braziliensis malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Schistosoma mansoni L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Mycobacterium ulcerans malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma cruzi cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania braziliensis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma brucei glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Plasmodium vivax malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH Get druggable targets OG5_127410 All targets in OG5_127410
Toxoplasma gondii malate dehydrogenase MDH Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus granulosus lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126911 All targets in OG5_126911
Neospora caninum Malate dehydrogenase (EC 1.1.1.37), related Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania braziliensis mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Neospora caninum Malate dehydrogenase (NAD) (EC 1.1.1.37) (Precursor), related Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase protein Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium berghei L-lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus multilocularis cytosolic malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania mexicana glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis malate and lactate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus granulosus L lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Echinococcus multilocularis lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania braziliensis glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania braziliensis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum L-lactate dehydrogenase B chain, putative Get druggable targets OG5_126911 All targets in OG5_126911
Leishmania donovani malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Candida albicans similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Brugia malayi Malate dehydrogenase, cytoplasmic Get druggable targets OG5_127410 All targets in OG5_127410
Leishmania infantum malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Babesia bovis lactate dehydrogenase Get druggable targets OG5_126911 All targets in OG5_126911
Plasmodium knowlesi malate dehydrogenase, putative Get druggable targets OG5_126911 All targets in OG5_126911
Chlamydia trachomatis malate dehydrogenase Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma cruzi glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania mexicana cytosolic malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trypanosoma brucei gambiense glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Entamoeba histolytica malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Trichomonas vaginalis malate dehydrogenase, putative Get druggable targets OG5_127410 All targets in OG5_127410
Echinococcus multilocularis lactate dehydrogenase a Get druggable targets OG5_126911 All targets in OG5_126911
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 344 aa 34.0 %
Dictyostelium discoideum malate dehydrogenase Malate dehydrogenase mitochondrial   338 aa 356 aa 23.9 %
Onchocerca volvulus Malate dehydrogenase cytoplasmic   334 aa 283 aa 23.7 %
Leishmania infantum malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 344 aa 33.7 %
Trypanosoma congolense malate dehydrogenase-related Malate dehydrogenase mitochondrial   338 aa 334 aa 29.9 %
Plasmodium falciparum lactate dehydrogenase, putative malate dehydrogenase 313 aa 307 aa 40.7 %
Leishmania major malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 344 aa 33.4 %
Leishmania braziliensis malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 348 aa 32.8 %
Brugia malayi lactate dehydrogenase. Malate dehydrogenase cytoplasmic   334 aa 327 aa 23.5 %
Trypanosoma brucei malate dehydrogenase-related Malate dehydrogenase mitochondrial   338 aa 337 aa 29.7 %
Trypanosoma brucei gambiense malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 338 aa 29.0 %
Plasmodium falciparum lactate dehydrogenase, putative L-lactate dehydrogenase 316 aa 307 aa 43.0 %
Onchocerca volvulus 28S ribosomal protein S31, mitochondrial homolog Malate dehydrogenase mitochondrial   338 aa 310 aa 59.7 %
Schistosoma mansoni malate dehydrogenase Malate dehydrogenase cytoplasmic   334 aa 339 aa 25.7 %
Toxoplasma gondii malate dehydrogenase MDH Malate dehydrogenase mitochondrial   338 aa 317 aa 28.4 %
Trypanosoma cruzi malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 339 aa 32.4 %
Leishmania mexicana malate dehydrogenase, putative Malate dehydrogenase mitochondrial   338 aa 336 aa 33.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0165 0.4677 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2473 0.8311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.009 0.1923 0.383
Brugia malayi lactate dehydrogenase. 0.0154 0.429 0.7059
Echinococcus granulosus nuclear receptor nhr 48 0.008 0.1567 0.2764
Schistosoma mansoni L-lactate dehydrogenase 0.0154 0.429 0.8746
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0171 0.4894 0.8053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0171 0.4894 0.8053
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0154 0.429 0.8687
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0171 0.4894 0.8053
Mycobacterium ulcerans thymidylate synthase 0.0117 0.2916 1
Brugia malayi nuclear hormone receptor 0.0171 0.4894 0.8053
Loa Loa (eye worm) hypothetical protein 0.009 0.1923 0.1923
Giardia lamblia Malate dehydrogenase 0.0116 0.2882 0.5
Loa Loa (eye worm) hypothetical protein 0.009 0.1923 0.1923
Brugia malayi hypothetical protein 0.009 0.1923 0.3165
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0171 0.4894 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.008 0.1567 0.2578
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.009 0.1923 0.1923
Loa Loa (eye worm) thymidylate synthase 0.0117 0.2916 0.2916
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Leishmania major glycosomal malate dehydrogenase 0.0108 0.2582 0.5218
Brugia malayi Nuclear hormone receptor-like 1 0.009 0.1923 0.3165
Loa Loa (eye worm) malate dehydrogenase 0.0108 0.2582 0.2582
Echinococcus multilocularis lactate dehydrogenase a 0.0154 0.429 0.8687
Brugia malayi nuclear receptor NHR-67 0.008 0.1567 0.2578
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.008 0.1567 0.309
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Schistosoma mansoni nuclear receptor 0.008 0.1567 0.309
Loa Loa (eye worm) hypothetical protein 0.009 0.1923 0.1923
Brugia malayi nuclear receptor NHR-88 0.008 0.1567 0.2578
Echinococcus granulosus FTZ F1 alpha 0.0171 0.4894 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0171 0.4894 0.4894
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2473 0.827
Schistosoma mansoni thyroid hormone receptor 0.0171 0.4894 1
Loa Loa (eye worm) steroid hormone receptor 0.0171 0.4894 0.4894
Chlamydia trachomatis malate dehydrogenase 0.0116 0.2882 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0171 0.4894 0.8053
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.1567 0.2764
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0086 0.1784 0.3396
Brugia malayi nuclear hormone receptor family member odr-7 0.008 0.1567 0.2578
Echinococcus multilocularis dihydrofolate reductase 0.0048 0.0358 0.0134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2906 0.9963
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0107 0.015
Schistosoma mansoni L-lactate dehydrogenase 0.0086 0.1784 0.354
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0116 0.2882 0.4053
Brugia malayi tailless protein 0.008 0.1567 0.2578
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0171 0.4894 1
Plasmodium falciparum L-lactate dehydrogenase 0.0154 0.429 0.9116
Brugia malayi orphan nuclear receptor NR2E1 0.008 0.1567 0.2578
Schistosoma mansoni steroid hormone receptor ad4bp 0.0171 0.4894 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0171 0.4894 1
Brugia malayi hypothetical protein 0.0056 0.0651 0.1071
Schistosoma mansoni chromobox protein 0.0068 0.1101 0.2121
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0171 0.4894 0.6882
Schistosoma mansoni zinc finger protein 0.008 0.1567 0.309
Trichomonas vaginalis set domain proteins, putative 0.0231 0.7111 1
Schistosoma mansoni nuclear hormone receptor 0.008 0.1567 0.309
Trypanosoma brucei glycosomal malate dehydrogenase 0.0108 0.2582 0.5218
Onchocerca volvulus 0.0171 0.4894 0.6882
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0116 0.2882 0.4053
Trypanosoma brucei malate dehydrogenase-related 0.0086 0.1784 0.3396
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.009 0.1923 0.3539
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0165 0.4677 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Trichomonas vaginalis malate dehydrogenase, putative 0.0072 0.1247 0.1754
Schistosoma mansoni malate dehydrogenase 0.0116 0.2882 0.5821
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Schistosoma mansoni nuclear receptor nhr-48 0.008 0.1567 0.309
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Loa Loa (eye worm) glutathione reductase 0.0046 0.0296 0.0296
Brugia malayi thymidylate synthase 0.0117 0.2916 0.4798
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0171 0.4894 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0116 0.2882 0.4053
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1101 0.1101
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0154 0.429 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0171 0.4894 0.4894
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0171 0.4894 1
Schistosoma mansoni retinoic acid receptor RXR 0.0171 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Brugia malayi hypothetical protein 0.008 0.1567 0.2578
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2906 0.9963
Echinococcus granulosus lactate dehydrogenase protein 0.0154 0.429 0.8687
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0116 0.2882 0.4053
Echinococcus multilocularis lactate dehydrogenase a 0.0154 0.429 0.8687
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Toxoplasma gondii lactate dehydrogenase LDH2 0.0154 0.429 0.9116
Loa Loa (eye worm) DR-78 0.008 0.1567 0.1567
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0107 0.015
Echinococcus granulosus lactate dehydrogenase a 0.0154 0.429 0.8687
Brugia malayi hypothetical protein 0.008 0.1567 0.2578
Brugia malayi nuclear hormone receptor 0.008 0.1567 0.2578
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.008 0.1567 0.309
Schistosoma mansoni malate dehydrogenase 0.0154 0.429 0.8746
Onchocerca volvulus Protein ultraspiracle homolog 0.0171 0.4894 0.6882
Echinococcus granulosus dihydrofolate reductase 0.0048 0.0358 0.0134
Brugia malayi glutathione reductase 0.0046 0.0296 0.0487
Brugia malayi Pre-SET motif family protein 0.0203 0.6077 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0171 0.4894 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0048 0.0358 0.0236
Brugia malayi nuclear receptor RXR 0.008 0.1567 0.2578
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0171 0.4894 0.8053
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0056 0.0651 0.0811
Brugia malayi Heterochromatin protein 1 0.0068 0.1101 0.1811
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0171 0.4894 1
Plasmodium vivax malate dehydrogenase, putative 0.0154 0.429 0.9116
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0116 0.2882 0.9871
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0171 0.4894 0.4894
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0171 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Plasmodium falciparum lactate dehydrogenase, putative 0.0086 0.1784 0.3396
Echinococcus granulosus chromobox protein 1 0.0068 0.1101 0.175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0171 0.4894 0.8053
Echinococcus multilocularis thymidylate synthase 0.0117 0.2916 0.5698
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0117 0.2916 0.5892
Echinococcus multilocularis ecdysone induced protein 78C 0.0171 0.4894 1
Leishmania major malate dehydrogenase 0.0108 0.2582 0.5218
Plasmodium falciparum malate dehydrogenase 0.0154 0.429 0.9116
Echinococcus granulosus cytosolic malate dehydrogenase 0.0116 0.2882 0.5624
Trypanosoma brucei cytosolic malate dehydrogenase 0.0116 0.2882 0.5902
Onchocerca volvulus 0.0231 0.7111 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0171 0.4894 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0086 0.1784 0.3396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.1567 0.2764
Onchocerca volvulus Bile acid receptor homolog 0.0171 0.4894 0.6882
Schistosoma mansoni dihydrofolate reductase 0.0048 0.0358 0.0578
Brugia malayi ecdysteroid receptor 0.0171 0.4894 0.8053
Echinococcus multilocularis chromobox protein 1 0.0068 0.1101 0.175
Loa Loa (eye worm) nuclear receptor NHR-67 0.008 0.1567 0.1567
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0171 0.4894 0.8053
Brugia malayi nuclear receptor RXR 0.009 0.1923 0.3165
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.1567 0.2764
Onchocerca volvulus 0.004 0.0079 0.0111
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2473 0.8311
Echinococcus multilocularis lactate dehydrogenase a 0.0154 0.429 0.8687
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0171 0.4894 1
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0116 0.2882 0.9867
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0171 0.4894 1
Schistosoma mansoni chromobox protein 0.0068 0.1101 0.2121
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Echinococcus multilocularis thyroid hormone receptor alpha 0.0171 0.4894 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0171 0.4894 0.4894
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0108 0.2582 0.5218
Mycobacterium tuberculosis Hypothetical protein 0.0056 0.0651 0.1356
Echinococcus granulosus lactate dehydrogenase a 0.0154 0.429 0.8687
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0116 0.2882 0.5624
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0108 0.2582 0.4249
Echinococcus multilocularis nuclear receptor nhr 48 0.008 0.1567 0.2764
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0651 0.0916
Echinococcus granulosus ecdysone induced protein 78C 0.0171 0.4894 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.008 0.1567 0.2764
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.1567 0.2764
Echinococcus multilocularis L lactate dehydrogenase 0.0068 0.1102 0.1754
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.1567 0.2764
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0116 0.2882 0.4742
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.1567 0.2204
Brugia malayi nuclear hormone receptor family member nhr-6 0.008 0.1567 0.2578
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0108 0.2582 0.5218
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0165 0.4677 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0171 0.4894 0.8053
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Schistosoma mansoni malate dehydrogenase 0.0116 0.2882 0.5821
Schistosoma mansoni thyroid hormone receptor 0.0171 0.4894 1
Brugia malayi conserved hypotetical protein 0.008 0.1567 0.2578
Brugia malayi dihydrofolate reductase family protein 0.0048 0.0358 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0171 0.4894 0.4894
Brugia malayi Thioredoxin reductase 0.0046 0.0296 0.0487
Brugia malayi Steroid receptor seven-up type 2 0.0171 0.4894 0.8053
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0107 0.015
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.008 0.1567 0.2764
Trichomonas vaginalis malate dehydrogenase, putative 0.0042 0.0149 0.021
Onchocerca volvulus 0.0117 0.2916 0.41
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0171 0.4894 1
Echinococcus granulosus thymidylate synthase 0.0117 0.2916 0.5698
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Schistosoma mansoni nuclear hormone receptor 0.0171 0.4894 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2473 0.8311
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Echinococcus granulosus thyroid hormone receptor alpha 0.008 0.1567 0.2764
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0171 0.4894 1
Onchocerca volvulus 0.008 0.1567 0.2204
Toxoplasma gondii malate dehydrogenase MDH 0.0154 0.429 0.9116
Brugia malayi nuclear receptor NHR-88 0.0171 0.4894 0.8053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0171 0.4894 0.8053
Echinococcus multilocularis chromobox protein 1 0.0068 0.1101 0.175
Brugia malayi hypothetical protein 0.009 0.1923 0.3165
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0108 0.2582 0.5218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0171 0.4894 1
Brugia malayi Nuclear hormone receptor E75 0.008 0.1567 0.2578
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.6077 0.6077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.1567 0.2764
Leishmania major cytosolic malate dehydrogenase 0.0116 0.2882 0.5902
Brugia malayi steroid hormone receptor 0.0171 0.4894 0.8053
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0117 0.2916 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0171 0.4894 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0108 0.2582 0.5218
Brugia malayi Dihydrofolate reductase 0.0048 0.0358 0.0588
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0171 0.4894 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0116 0.2882 0.5624
Loa Loa (eye worm) hypothetical protein 0.0171 0.4894 0.4894
Toxoplasma gondii lactate dehydrogenase LDH1 0.0154 0.429 0.9116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0171 0.4894 0.8053
Leishmania major mitochondrial malate dehydrogenase 0.0108 0.2582 0.5218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2473 0.8311
Mycobacterium tuberculosis Probable reductase 0.0105 0.2473 0.8311
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0108 0.2582 0.5218
Schistosoma mansoni RAR-like nuclear receptor 0.0171 0.4894 1
Leishmania major malate dehydrogenase, putative 0.0154 0.429 0.9116
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.008 0.1567 0.2764
Echinococcus multilocularis malate dehydrogenase 0.0108 0.2582 0.4972
Loa Loa (eye worm) malate dehydrogenase 0.0116 0.2882 0.2882
Leishmania major malate dehydrogenase, putative 0.0086 0.1784 0.3396
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.009 0.1923 0.383
Echinococcus granulosus chromobox protein 1 0.0068 0.1101 0.175
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2906 0.9963
Echinococcus granulosus L lactate dehydrogenase 0.0068 0.1102 0.1754
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0171 0.4894 0.8053
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0165 0.4677 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0171 0.4894 1
Echinococcus granulosus malate dehydrogenase 0.0108 0.2582 0.4972
Echinococcus multilocularis malate dehydrogenase 0.0108 0.2582 0.4972
Brugia malayi ecdysone receptor 0.008 0.1567 0.2578
Brugia malayi photoreceptor-specific nuclear receptor 0.0171 0.4894 0.8053
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.008 0.1567 0.1567
Loa Loa (eye worm) nuclear hormone receptor 0.008 0.1567 0.1567
Schistosoma mansoni nuclear hormone receptor 0.008 0.1567 0.309
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Loa Loa (eye worm) hypothetical protein 0.009 0.1923 0.1923
Echinococcus granulosus malate dehydrogenase 0.0108 0.2582 0.4972
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.009 0.1923 0.3539
Brugia malayi Nuclear hormone receptor-like 1 0.009 0.1923 0.3165
Schistosoma mansoni malate dehydrogenase 0.0108 0.2582 0.5199
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Schistosoma mansoni nuclear receptor 0.008 0.1567 0.309
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1101 0.1548
Brugia malayi hypothetical protein 0.0119 0.2972 0.489
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0165 0.4677 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2473 0.8311
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0116 0.2882 0.5902
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1101 0.1548
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0117 0.2916 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0171 0.4894 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0116 0.2882 0.5624
Echinococcus multilocularis lactate dehydrogenase protein 0.0154 0.429 0.8687
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2906 0.9962
Loa Loa (eye worm) hypothetical protein 0.008 0.1567 0.1567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0171 0.4894 0.4894
Plasmodium vivax lactate dehydrogenase 0.0154 0.429 0.9116
Schistosoma mansoni coup transcription factor 0.0171 0.4894 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0171 0.4894 0.4894
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0165 0.4677 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Schistosoma mansoni hypothetical protein 0.005 0.0455 0.0781
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0171 0.4894 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0171 0.4894 0.8053
Brugia malayi Nuclear hormone receptor-like 1 0.0171 0.4894 0.8053
Loa Loa (eye worm) dihydrofolate reductase 0.0048 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.009 0.1923 0.1923
Entamoeba histolytica malate dehydrogenase, putative 0.0154 0.429 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0116 0.2882 0.4053
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.1567 0.2204
Echinococcus multilocularis FTZ F1 alpha 0.0171 0.4894 1
Onchocerca volvulus 0.008 0.1567 0.2204
Mycobacterium ulcerans malate dehydrogenase 0.0116 0.2882 0.9867
Trichomonas vaginalis malate dehydrogenase, putative 0.0086 0.1784 0.2508
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0116 0.2882 0.5902
Brugia malayi Nuclear hormone receptor E75 0.008 0.1567 0.2578
Loa Loa (eye worm) hypothetical protein 0.0154 0.429 0.429
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0171 0.4894 0.8053
Echinococcus granulosus L lactate dehydrogenase B chain 0.0154 0.429 0.8687

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.72 uM Inhibition of pig heart mitochondrial MDH ChEMBL. 17636950
IC50 (binding) = 2.72 uM Inhibition of pig heart mitochondrial MDH ChEMBL. 17636950
IC50 (binding) = 3.13 uM Inhibition of Plasmodium falciparum LDH ChEMBL. 17636950
IC50 (binding) = 3.13 uM Inhibition of Plasmodium falciparum LDH ChEMBL. 17636950
IC50 (binding) = 4.88 uM Inhibition of pig cytosolic MDH ChEMBL. 17636950
IC50 (binding) = 4.88 uM Inhibition of pig cytosolic MDH ChEMBL. 17636950
IC50 (binding) = 6.76 uM Inhibition of Plasmodium falciparum MDH ChEMBL. 17636950
IC50 (binding) = 6.76 uM Inhibition of Plasmodium falciparum MDH ChEMBL. 17636950
IC50 (binding) > 187 uM Inhibition of bovine heart LDH ChEMBL. 17636950
Ratio IC50 (binding) = 59 Selectivity for Plasmodium falciparum LDH over bovine heart LDH ChEMBL. 17636950

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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