Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.1061 | 0.1061 |
Echinococcus granulosus | FTZ F1 alpha | 0.0017 | 0.0047 | 0.0115 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0162 | 0.0162 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0153 | 0.0707 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0335 | 0.115 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0279 | 0.1301 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0047 | 0.022 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0153 | 0.0707 |
Onchocerca volvulus | 0.0081 | 0.0868 | 1 | |
Brugia malayi | hypoxia-induced factor 1 | 0.0164 | 0.1935 | 0.9159 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.1061 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0.0047 | 0.0536 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0.0047 | 0.0536 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0047 | 0.02 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0335 | 0.115 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0047 | 0.022 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.0868 | 0.4099 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0017 | 0.0047 | 0.0047 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0047 | 0.0047 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0047 | 0.02 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0162 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0153 | 0.0707 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0047 | 0.0115 |
Echinococcus granulosus | tumor protein p63 | 0.033 | 0.4063 | 1 |
Brugia malayi | hypothetical protein | 0.0178 | 0.2112 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0017 | 0.0047 | 0.02 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0212 | 0.2554 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0286 | 0.8082 |
Onchocerca volvulus | 0.0026 | 0.0162 | 0.1864 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0017 | 0.0047 | 0.022 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0162 | 0.0398 |
Brugia malayi | Blistered cuticle protein 3 | 0.0026 | 0.0153 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2112 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1336 | 0.6325 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0047 | 0.02 |
Onchocerca volvulus | 0.0048 | 0.0443 | 0.5105 | |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0354 | 0.1659 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0212 | 0.2554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0047 | 0.0115 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0286 | 0.1794 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0286 | 0.8082 |
Brugia malayi | nuclear receptor NHR-88 | 0.0017 | 0.0047 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Schistosoma mansoni | single-minded | 0.0053 | 0.0505 | 0.1829 |
Onchocerca volvulus | 0.0017 | 0.0047 | 0.0536 | |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0986 | 0.2426 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0443 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0156 | 0.0737 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0212 | 0.2554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0354 | 0.1676 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0153 | 0.0726 |
Onchocerca volvulus | Peroxidase homolog | 0.0026 | 0.0153 | 0.1765 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0047 | 0.02 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.0868 | 0.0868 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0238 | 0.093 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0354 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0279 | 0.1715 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0279 | 0.1715 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0286 | 0.0956 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0047 | 0.02 |
Schistosoma mansoni | peroxidasin | 0.0026 | 0.0153 | 0.0426 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0153 | 0.0707 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0047 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Schistosoma mansoni | peroxidasin | 0.0026 | 0.0153 | 0.0426 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0474 | 0.2242 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0162 | 0.0747 |
Echinococcus granulosus | peroxidasin | 0.0026 | 0.0153 | 0.0377 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0212 | 0.2554 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0047 | 0.022 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0047 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Schistosoma mansoni | lamin | 0.0026 | 0.0162 | 0.046 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0286 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0286 | 0.8082 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0286 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0286 | 0.0695 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0286 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0986 | 0.0986 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0286 | 0.1355 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0047 | 0.02 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.1061 | 0.5013 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0017 | 0.0047 | 0.02 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0354 | 0.0354 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0286 | 0.0956 |
Echinococcus multilocularis | tumor protein p63 | 0.033 | 0.4063 | 0.4063 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0047 | 0.0047 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0286 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0354 | 0.1676 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0354 | 0.0871 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0117 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1061 | 0.5023 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.1061 | 0.2611 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0286 | 0.0695 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0354 | 0.1227 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0026 | 0.0153 | 0.1765 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0279 | 0.0926 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0047 | 0.02 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0162 | 0.0162 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0047 | 0.02 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0017 | 0.0047 | 0.02 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0162 | 0.0766 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.108 | 0.4123 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0212 | 0.2554 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0026 | 0.0153 | 0.1765 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0117 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0017 | 0.0047 | 0.0115 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0.0328 | 0.0866 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0279 | 0.1715 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0053 | 0.0505 | 0.1829 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0047 | 0.02 |
Onchocerca volvulus | Dual oxidase homolog | 0.0026 | 0.0153 | 0.1765 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0162 | 0.0398 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0335 | 0.115 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0047 | 0.02 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0286 | 0.1337 |
Echinococcus granulosus | single minded 2 | 0.0039 | 0.0328 | 0.0807 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0017 | 0.0047 | 0.022 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0117 | 0.408 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0039 | 0.0328 | 0.0328 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0017 | 0.0047 | 0.0047 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1336 | 0.6325 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0153 | 0.0726 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0335 | 0.115 |
Onchocerca volvulus | 0.0026 | 0.0153 | 0.1765 | |
Onchocerca volvulus | 0.0026 | 0.0153 | 0.1765 | |
Brugia malayi | steroid hormone receptor | 0.0017 | 0.0047 | 0.02 |
Brugia malayi | nuclear hormone receptor | 0.0017 | 0.0047 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.0868 | 0.2137 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0026 | 0.0153 | 0.0726 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0047 | 0.0047 |
Brugia malayi | ecdysteroid receptor | 0.0017 | 0.0047 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0443 | 0.2099 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0286 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0153 | 0.0707 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0153 | 0.0726 |
Onchocerca volvulus | Peroxidasin homolog | 0.0026 | 0.0153 | 0.1765 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Onchocerca volvulus | 0.0026 | 0.0153 | 0.1765 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0279 | 0.0926 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0117 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0004 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0279 | 0.1715 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0017 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0047 | 0.022 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0017 | 0.0047 | 0.0115 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0047 | 0.0115 |
Brugia malayi | bHLH-PAS transcription factor | 0.0039 | 0.0328 | 0.1534 |
Brugia malayi | PAS domain containing protein | 0.0053 | 0.0505 | 0.2376 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0162 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0868 | 0.4111 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1336 | 0.6317 |
Onchocerca volvulus | Peroxidase homolog | 0.0026 | 0.0153 | 0.1765 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0162 | 0.0747 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0026 | 0.0153 | 0.0726 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0047 | 0.02 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0279 | 0.0686 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0047 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0138 | 0.1593 | 0.3919 |
Echinococcus multilocularis | peroxidasin | 0.0026 | 0.0153 | 0.0153 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0286 | 0.0704 |
Onchocerca volvulus | 0.0026 | 0.0162 | 0.1864 | |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0238 | 0.0496 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0047 | 0.022 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0047 | 0.0115 |
Brugia malayi | Peroxidasin | 0.0026 | 0.0153 | 0.0707 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0138 | 0.1593 | 0.1593 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0047 | 0.022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0354 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0017 | 0.0047 | 0.0047 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0017 | 0.0047 | 0.0115 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0162 | 0.0766 |
Brugia malayi | Animal haem peroxidase family protein | 0.0026 | 0.0153 | 0.0707 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0164 | 0.1935 | 0.916 |
Echinococcus granulosus | lamin | 0.0026 | 0.0162 | 0.0398 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0047 | 0.0047 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0047 | 0.02 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0117 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0429 | 0.0429 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0162 | 0.0162 |
Schistosoma mansoni | lamin | 0.0026 | 0.0162 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0726 |
Onchocerca volvulus | 0.0039 | 0.0328 | 0.3774 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0279 | 0.0279 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0.0047 | 0.0536 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.0868 | 0.3278 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0117 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 210 % | Antitumour activity in L1210 cells xenografted B6D2F1 mouse at 40 mg/kg, ip relative to control | ChEMBL. | 17658777 |
IC50 (functional) | = 3.7 uM | Antiproliferative activity against LoVo cells after 72 hrs by MTT assay | ChEMBL. | 17658777 |
IC50 (functional) | = 3.9 uM | Antiproliferative activity against A549 cells after 72 hrs by MTT assay | ChEMBL. | 17658777 |
IC50 (functional) | = 4.3 uM | Antiproliferative activity against HCT15 cells after 72 hrs by MTT assay | ChEMBL. | 17658777 |
IC50 (functional) | = 4.7 uM | Antiproliferative activity against U373MG cells after 72 hrs by MTT assay | ChEMBL. | 17658777 |
IC50 (functional) | = 4.9 uM | Antiproliferative activity against Hs683 cells after 72 hrs by MTT assay | ChEMBL. | 17658777 |
IC50 (functional) | = 6.3 uM | Antiproliferative activity against MCF7 cells after 72 hrs by MTT assay | ChEMBL. | 17658777 |
MTD (ADMET) | = 40 mg kg-1 | Toxicity in ip dosed B6D2F1 mouse | ChEMBL. | 17658777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.