Detailed information for compound 435494

Basic information

Technical information
  • TDR Targets ID: 435494
  • Name: 4-amino-3-(2-chloro-5-methoxyphenyl)-1H-1,2,4 -triazole-5-thione
  • MW: 256.712 | Formula: C9H9ClN4OS
  • H donors: 1 H acceptors: 2 LogP: 1.92 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)c1nnc(n1N)S)Cl
  • InChi: 1S/C9H9ClN4OS/c1-15-5-2-3-7(10)6(4-5)8-12-13-9(16)14(8)11/h2-4H,11H2,1H3,(H,13,16)
  • InChiKey: XQIXEFBYVPLPJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-3-(2-chloro-5-methoxy-phenyl)-1H-1,2,4-triazole-5-thione
  • 4-azanyl-3-(2-chloro-5-methoxy-phenyl)-1H-1,2,4-triazole-5-thione
  • 4-amino-5-(2-chloro-5-methoxyphenyl)-2H-1,2,4-triazole-3-thione
  • 4-amino-5-(2-chloro-5-methoxy-phenyl)-2H-1,2,4-triazole-3-thione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.4314
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0589 0.051
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0589 0.5322
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0028 0.0374 0.0448
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0044 0.0739 0.0661
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1033 1
Schistosoma mansoni glucose transport protein 0.0108 0.216 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.3926 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.4314
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0028 0.0374 0.0954
Schistosoma mansoni protein kinase 0.0033 0.0484 0.1927
Brugia malayi Cam kinase protein 1 0.0033 0.0484 0.1041
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0283 0.2102
Plasmodium vivax hexose transporter 0.0108 0.216 0.2094
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0028 0.0374 0.6461
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0283 0.0961
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0283 0.0201
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 0.5322
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0028 0.0374 0.14
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0484 0.1041
Loa Loa (eye worm) sugar transporter 0.0015 0.0084 0.0109
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Leishmania major glucose transporter, lmgt3 0.0033 0.0493 0.4314
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.0961
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.3926 1
Trypanosoma brucei glucose transporter 2A 0.0033 0.0493 0.4314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0283 0.0519
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0283 0.2102
Leishmania major glucose transporter, lmgt2 0.0033 0.0493 0.4314
Schistosoma mansoni glucose transport protein 0.0108 0.216 1
Brugia malayi Sugar transporter family protein 0.0108 0.216 0.5404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Plasmodium falciparum protein kinase 7 0.0304 0.6571 0.6542
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.3926 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0589 0.0779
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0469 0.0509
Loa Loa (eye worm) methionine aminopeptidase type I 0.0044 0.0739 0.1795
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.216 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0469 0.1002
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0186 0.3926 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.1033 0.2471
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.4314
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3649 0.3595
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0154 0.0736
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0108 0.026
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.1066
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0028 0.0374 0.1139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Trypanosoma brucei methionine aminopeptidase, putative 0.0044 0.0739 0.69
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0739 0.69
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0589 0.051
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.0722
Entamoeba histolytica protein kinase, putative 0.0033 0.0484 0.0551
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0283 0.7566
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0108 0.0025
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0622
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0484 0.1927
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0469 0.1855
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0484 0.0617
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.4314
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0484 0.0617
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0484 0.0404
Plasmodium falciparum HP12 protein homolog, putative 0.0016 0.0108 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0484 0.1041
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.216 1
Leishmania major protein kinase, putative 0.0033 0.0484 0.4214
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0493 0.1066
Trypanosoma brucei glucose transporter 1E 0.0033 0.0493 0.4314
Toxoplasma gondii protein kinase, putative 0.0304 0.6571 1
Loa Loa (eye worm) sugar transporter 0.0108 0.216 0.5454
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0484 0.1139
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0739 0.3155
Plasmodium falciparum hexose transporter 0.0108 0.216 0.2094
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0044 0.0739 0.69
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.3926 1
Trypanosoma cruzi hexose transporter 0.0033 0.0493 0.4314
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0493 0.1066
Schistosoma mansoni protein kinase 0.0033 0.0484 0.1927
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0044 0.0739 0.3155
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0484 0.0404
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0186 0.3926 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.0961
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0283 0.0201
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0217 0.0346
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0028 0.0374 0.6461
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0186 0.3926 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1033 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0484 0.0404
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0484 0.0404
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0283 0.2102
Entamoeba histolytica protein kinase, putative 0.0033 0.0484 0.0551
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3649 0.5495
Onchocerca volvulus 0.0186 0.3926 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0044 0.0739 0.69
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0493 0.1066
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0028 0.0374 0.14
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Brugia malayi Methionine aminopeptidase protein type I 0.0044 0.0739 0.1705
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0438 0.1707
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.216 0.5404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.1033 1
Leishmania major glucose transporter, lmgt1 0.0033 0.0493 0.4314
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0283 0.0308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0333 0.075
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0469 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0129 0.2637 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Mycobacterium ulcerans methionine aminopeptidase 0.0028 0.0374 0.0954
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.216 1
Toxoplasma gondii hypothetical protein 0.0016 0.0108 0.0038
Chlamydia trachomatis methionine aminopeptidase 0.0028 0.0374 1
Echinococcus granulosus General substrate transporter 0.0092 0.1821 0.8364
Leishmania major hypothetical protein, conserved 0.0016 0.0108 0.026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0109
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0202 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0484 0.1139
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0484 0.0404
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0028 0.0374 0.0293
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0186 0.3926 1
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0283 0.0961
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.4314
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0084 0.0213
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0283 0.3046
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.1066
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.0722
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0108 0.026
Mycobacterium ulcerans sugar transporter 0.0015 0.0084 0.0213
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0283 0.0519
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 0.5322
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0028 0.0374 0.0293
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.216 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0469 0.1855
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0493 0.4314
Treponema pallidum methionine aminopeptidase (map) 0.0028 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0589 0.5322
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0493 0.1066
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.216 0.3201
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0438 0.1707
Schistosoma mansoni glucose transport protein 0.0108 0.216 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0484 0.1927
Leishmania major hypothetical protein, conserved 0.0057 0.1033 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0109
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0283 0.0519
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0469 0.1002
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.216 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0484 0.0404
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0084 0.0213
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.216 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0484 0.4214
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 0.5322
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3649 0.3595
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.4314
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0739 0.69
Loa Loa (eye worm) hypothetical protein 0.0032 0.0469 0.11
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0469 0.1855
Echinococcus multilocularis General substrate transporter 0.0092 0.1821 0.8364
Schistosoma mansoni hypothetical protein 0.0108 0.216 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4314
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.3926 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.1033 0.2471
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0028 0.0374 0.14
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0202 0.0463
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.3926 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.3926 1
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0739 0.101
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.3926 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0084 0.0213
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0484 0.1139
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0108 0.026
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0469 0.1002
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0469 0.1002
Schistosoma mansoni protein kinase 0.0033 0.0484 0.1927
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.1066
Toxoplasma gondii methionine aminopeptidase 0.0028 0.0374 0.0448
Plasmodium vivax CDK-related protein kinase 6, putative 0.0457 1 1
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0044 0.0739 0.69
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0109
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0028 0.0374 0.1139
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0484 0.0617
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0469 0.1855
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0044 0.0739 0.0661
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0028 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0469 0.11
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.216 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.1927
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.216 1

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 2.33 mm Antifungal activity against Candida albicans at 10 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 2.33 mm Antifungal activity against Candida albicans at 10 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 2.59 mm Antifungal activity against Aspergillus niger at 10 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 4.25 mm Antibacterial activity against Bacillus subtilis at 10 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 5.02 mm Antifungal activity against Aspergillus niger at 20 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 5.08 mm Antibacterial activity against Escherichia coli at 10 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 5.08 mm Antibacterial activity against Escherichia coli at 10 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 5.16 mm Antibacterial activity against Staphylococcus aureus at 10 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 5.18 mm Antifungal activity against Candida albicans at 20 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 5.18 mm Antifungal activity against Candida albicans at 20 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 5.23 mm Antibacterial activity against Pseudomonas aeruginosa at 10 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 7.05 mm Antibacterial activity against Bacillus subtilis at 20 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 7.16 mm Antibacterial activity against Escherichia coli at 20 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 7.16 mm Antibacterial activity against Escherichia coli at 20 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 7.26 mm Antibacterial activity against Pseudomonas aeruginosa at 20 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 7.28 mm Antibacterial activity against Staphylococcus aureus at 20 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 9.06 mm Antibacterial activity against Staphylococcus aureus at 30 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 9.1 mm Antibacterial activity against Pseudomonas aeruginosa at 30 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 9.17 mm Antibacterial activity against Escherichia coli at 30 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 9.17 mm Antibacterial activity against Escherichia coli at 30 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 9.79 mm Antifungal activity against Candida albicans at 30 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 9.79 mm Antifungal activity against Candida albicans at 30 ug/ml by paper disc method ChEMBL. 17331622
IZ (functional) = 10.11 mm Antibacterial activity against Bacillus subtilis at 30 ug/ml by agar plate diffusion technique ChEMBL. 17331622
IZ (functional) = 11.04 mm Antifungal activity against Aspergillus niger at 30 ug/ml by paper disc method ChEMBL. 17331622

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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