Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | Curated by TDR Targets | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 1 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.2507 | 0.4535 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.4785 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 1 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.4785 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.0618 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.0618 | 0.1067 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.0618 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.0618 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.4785 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.4785 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.0618 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.4785 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0133 | 0.2507 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.4785 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.9 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
IC50 (binding) | = 4.9 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
Inhibition (binding) | = 50 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rats plasma at 1 mg/kg, po after 10 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 50 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rats plasma at 1 mg/kg, po after 10 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 84 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 84 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.