Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0428 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.1439 | 0.5464 | 0.5979 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.0506 | 0.0876 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.2252 | 0.8573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0075 | 0.0129 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.021 | 0.0364 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0731 | 0.2757 | 0.3216 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0708 | 0.2672 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.1439 | 0.5464 | 0.6374 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.1522 | 0.578 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0735 | 0.1272 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0002 | 0.0002 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.1439 | 0.5464 | 0.6374 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0002 | 0.002 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0735 | 0.0858 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.2252 | 0.8573 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0506 | 0.0591 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0075 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.021 | 0.0245 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0002 | 0.0003 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.2252 | 0.8573 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.1439 | 0.5464 | 0.9454 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0428 | 0.05 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0075 | 0.0087 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.021 | 0.0245 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.2252 | 0.8573 | 0.5 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.021 | 0.0245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0071 | 0.0083 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Onchocerca volvulus | 0.023 | 0.0842 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0002 | 0.0003 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0708 | 0.2672 | 0.5 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.2252 | 0.8573 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.1439 | 0.5464 | 0.5979 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.0506 | 0.0591 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0002 | 0.002 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0002 | 0.0002 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.021 | 0.0364 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0002 | 0.002 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.1439 | 0.5464 | 0.9454 |
Loa Loa (eye worm) | hypothetical protein | 0.1439 | 0.5464 | 0.9454 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0075 | 0.0087 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | RNA binding protein | 0.0064 | 0.021 | 0.0245 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0075 | 0.0087 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.2252 | 0.8573 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0002 | 0.0003 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0813 | 0.3073 | 0.3584 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0428 | 0.0741 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.021 | 0.0364 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0002 | 0.0003 |
Onchocerca volvulus | 0.0029 | 0.0075 | 0.0889 | |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0002 | 0.0003 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.1522 | 0.578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0075 | 0.0087 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0506 | 0.0591 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0813 | 0.3073 | 0.2886 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.001 | 0.0002 | 0.002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 10 uM kg-1 | Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure | ChEMBL. | 6620302 |
ED30 (functional) | = 12 uM kg-1 | Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure | ChEMBL. | 6620302 |
ED30 (functional) | = 15 uM kg-1 | Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure after 30 minutes | ChEMBL. | 6620302 |
ED30 (functional) | = 30 uM kg-1 | Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure after 30 minutes | ChEMBL. | 6620302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.