Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Saccharomyces cerevisiae | Ltp1p | Starlite/ChEMBL | References |
Homo sapiens | acid phosphatase 1, soluble | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) | acid phosphatase 1, soluble | 112 aa | 107 aa | 24.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0452 | 0.6307 | 0.5 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0452 | 0.6307 | 0.6307 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0042 | 0.0118 | 0.0118 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0452 | 0.6307 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0042 | 0.0118 | 0.5 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0073 | 0.059 | 0.059 |
Schistosoma mansoni | amine oxidase | 0.0042 | 0.0118 | 0.0118 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0452 | 0.6307 | 0.6307 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0697 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.059 | 0.8388 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0697 | 1 | 1 |
Onchocerca volvulus | 0.0452 | 0.6307 | 1 | |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0042 | 0.0118 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Schistosoma mansoni | amine oxidase | 0.0042 | 0.0118 | 0.0118 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0042 | 0.0118 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0042 | 0.0118 | 0.5 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0312 | 0.4206 | 0.5349 |
Onchocerca volvulus | 0.0073 | 0.059 | 0.0935 | |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0042 | 0.0118 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.1592 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.1592 | 1 |
Echinococcus multilocularis | 0.0042 | 0.0118 | 0.0118 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0042 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0697 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.059 | 0.8388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0452 | 0.6307 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0042 | 0.0118 | 0.0118 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0452 | 0.6307 | 0.7484 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0139 | 0.1592 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0042 | 0.0118 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0042 | 0.0118 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0452 | 0.6307 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.059 | 0.059 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0042 | 0.0118 | 0.0118 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0452 | 0.6307 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0042 | 0.0118 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0452 | 0.6307 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0118 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0452 | 0.6307 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0042 | 0.0118 | 0.0118 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0042 | 0.0118 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0042 | 0.0118 | 0.0118 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0042 | 0.0118 | 0.0118 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0548 | 0.7762 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.1592 | 1 |
Onchocerca volvulus | 0.0042 | 0.0118 | 0.0187 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0452 | 0.6307 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0118 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0042 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0073 | 0.059 | 0.059 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0452 | 0.6307 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibition of human protein-tyrosine phosphatase 1B | ChEMBL. | 17543532 |
IC50 (binding) | = 1.1 uM | Inhibition of human protein-tyrosine phosphatase 1B | ChEMBL. | 17543532 |
IC50 (binding) | = 7.1 uM | Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1 | ChEMBL. | 17543532 |
IC50 (binding) | = 7.1 uM | Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1 | ChEMBL. | 17543532 |
IC50 (binding) | = 18.4 uM | Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2 | ChEMBL. | 17543532 |
IC50 (binding) | = 18.4 uM | Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2 | ChEMBL. | 17543532 |
IC50 (binding) | = 19.7 uM | Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1 | ChEMBL. | 17543532 |
IC50 (binding) | = 19.7 uM | Inhibition of Saccharomyces cerevisiae low molecular weight Protein-tyrosine phosphatase Ltp1 | ChEMBL. | 17543532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.