Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 5 receptor | Starlite/ChEMBL | References |
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melanocortin 5 receptor | 325 aa | 311 aa | 20.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Replicative DNA helicase | 0.0661 | 1 | 1 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0108 | 0.0703 | 0.0919 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.0089 | 0.0116 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 0.3006 | 0.8686 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0703 | 0.203 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0029 | 0.0083 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.3461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2397 | 0.6927 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0104 | 0.0642 | 0.084 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0661 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1288 | 0.3721 |
Brugia malayi | MH2 domain containing protein | 0.0245 | 0.3006 | 0.8686 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.0089 | 0.0089 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0209 | 0.2397 | 0.6927 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.0089 | 0.0116 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.2051 | 0.1027 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0108 | 0.0703 | 0.0703 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0209 | 0.2397 | 0.6927 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0661 | 1 | 0.5 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0104 | 0.0642 | 0.084 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0661 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0661 | 1 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0661 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0521 | 0.7648 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.3461 | 1 |
Echinococcus multilocularis | geminin | 0.0521 | 0.7648 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.3461 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.0089 | 0.0116 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0178 | 0.1889 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0272 | 0.3461 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0521 | 0.7648 | 0.7648 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0209 | 0.2397 | 0.6927 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.3461 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1288 | 0.1288 |
Loa Loa (eye worm) | twinkle helicase | 0.0189 | 0.2065 | 0.5965 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.3461 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0272 | 0.3461 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0108 | 0.0703 | 0.0703 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0108 | 0.0703 | 0.0919 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.0089 | 0.0116 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 0.3006 | 0.8686 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0143 | 0.1288 | 0.3721 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.0089 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0521 | 0.7648 | 0.7648 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0188 | 0.2051 | 0.1027 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0272 | 0.3461 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at MC5 receptor expressed in COS1 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 | |
Activity (functional) | Antagonist activity at MC4 receptor expressed in COS1 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 | |
Activity (functional) | Antagonist activity MC1 receptor in mouse B16 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 | |
Activity (functional) | 0 | Antagonist activity at MC3 receptor expressed in COS1 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 |
Activity (functional) | 0 | Antagonist activity MC1 receptor in mouse B16 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 |
Activity (functional) | 0 | Antagonist activity at MC4 receptor expressed in COS1 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 |
Activity (functional) | 0 | Antagonist activity at MC5 receptor expressed in COS1 cells assessed as inhibition of alpha-MSH-induced cAMP accumulation at 100 uM | ChEMBL. | 17618123 |
Ki (binding) | = 12 uM | Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells | ChEMBL. | 17618123 |
Ki (binding) | = 12 uM | Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells | ChEMBL. | 17618123 |
Ki (binding) | = 13 uM | Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 13 uM | Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 16 uM | Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 16 uM | Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 53 uM | Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 53 uM | Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.