Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Arachidonate 15-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Arachidonate 15-lipoxygenase | 663 aa | 676 aa | 23.2 % |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Arachidonate 15-lipoxygenase | 663 aa | 676 aa | 22.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2657 | 0.3077 | 0.3077 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0128 | 0 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0877 | 0.0911 | 0.0911 |
Brugia malayi | hypothetical protein | 0.0335 | 0.0252 | 0.042 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0335 | 0.0252 | 0.042 |
Loa Loa (eye worm) | cathepsin B | 0.0877 | 0.0911 | 0.1518 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0335 | 0.0252 | 0.042 |
Echinococcus multilocularis | cathepsin b | 0.2657 | 0.3077 | 0.5129 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0335 | 0.0252 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0335 | 0.0252 | 0.042 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0209 | 0.0098 | 0.0164 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0128 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0209 | 0.0098 | 0.0098 |
Plasmodium vivax | aspartyl protease, putative | 0.0335 | 0.0252 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Plasmodium vivax | plasmepsin V, putative | 0.0335 | 0.0252 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Plasmodium vivax | plasmepsin IV, putative | 0.0335 | 0.0252 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.2657 | 0.3077 | 0.3077 |
Toxoplasma gondii | cathepsin B | 0.0877 | 0.0911 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0877 | 0.0911 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2657 | 0.3077 | 0.3077 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.2206 | 0.2529 | 0.4215 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0335 | 0.0252 | 0.042 |
Plasmodium falciparum | plasmepsin VI | 0.0335 | 0.0252 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.0252 | 0.042 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0335 | 0.0252 | 0.042 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0335 | 0.0252 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0335 | 0.0252 | 0.5 |
Plasmodium falciparum | plasmepsin X | 0.0335 | 0.0252 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2657 | 0.3077 | 0.3077 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.0252 | 0.042 |
Plasmodium falciparum | plasmepsin IX | 0.0335 | 0.0252 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0335 | 0.0252 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.2657 | 0.3077 | 0.5129 |
Onchocerca volvulus | 0.0335 | 0.0252 | 1 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.5059 | 0.6 | 0.6 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0209 | 0.0098 | 0.0164 |
Plasmodium falciparum | plasmepsin V | 0.0335 | 0.0252 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.5059 | 0.6 | 1 |
Echinococcus granulosus | cathepsin b | 0.2657 | 0.3077 | 0.5129 |
Giardia lamblia | Cathepsin B precursor | 0.0877 | 0.0911 | 1 |
Echinococcus multilocularis | cathepsin b | 0.2657 | 0.3077 | 0.5129 |
Onchocerca volvulus | 0.0335 | 0.0252 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0877 | 0.0911 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Plasmodium falciparum | plasmepsin IV | 0.0335 | 0.0252 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0335 | 0.0252 | 0.042 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0877 | 0.0911 | 1 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0335 | 0.0252 | 0.042 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.2657 | 0.3077 | 0.5129 |
Giardia lamblia | Cathepsin B precursor | 0.0877 | 0.0911 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2657 | 0.3077 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.5059 | 0.6 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.5059 | 0.6 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.5059 | 0.6 | 1 |
Brugia malayi | hypothetical protein | 0.0335 | 0.0252 | 0.042 |
Plasmodium falciparum | plasmepsin VII | 0.0335 | 0.0252 | 0.5 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0335 | 0.0252 | 0.042 |
Giardia lamblia | Cathepsin B precursor | 0.0877 | 0.0911 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Brugia malayi | Pepsin A precursor | 0.0335 | 0.0252 | 0.042 |
Plasmodium vivax | aspartyl protease, putative | 0.0335 | 0.0252 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0335 | 0.0252 | 0.0252 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.2206 | 0.2529 | 0.4215 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0335 | 0.0252 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0877 | 0.0911 | 0.296 |
Plasmodium falciparum | plasmepsin III | 0.0335 | 0.0252 | 0.5 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0128 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2657 | 0.3077 | 0.5129 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.0252 | 0.042 |
Plasmodium falciparum | plasmepsin II | 0.0335 | 0.0252 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0335 | 0.0252 | 0.2764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.