Detailed information for compound 450064

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 273.33 | Formula: C15H19N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1NC(C)c2c(C1)c1cc(C)cnc1n2C
  • InChi: 1S/C15H19N3O2/c1-8-5-11-10-6-12(15(19)20-4)17-9(2)13(10)18(3)14(11)16-7-8/h5,7,9,12,17H,6H2,1-4H3
  • InChiKey: ICZSAKIFKKBPTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0591 0.9813
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.325 0.3246
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0251 0.7153 0.7152
Brugia malayi Nuclear hormone receptor-like 1 0.0251 0.7153 0.7152
Schistosoma mansoni coup transcription factor 0.0251 0.7153 0.7152
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0347 1 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.0163
Trichomonas vaginalis AGC family protein kinase 0.001 0.0007 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0251 0.7153 0.7152
Brugia malayi Steroid receptor seven-up type 2 0.0251 0.7153 0.7152
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0251 0.7153 0.7152
Schistosoma mansoni hypothetical protein 0.034 0.9806 0.9806
Brugia malayi nuclear receptor NHR-88 0.0251 0.7153 0.7152
Brugia malayi ecdysone receptor 0.0118 0.3215 0.321
Entamoeba histolytica protein kinase 2, putative 0.002 0.0297 0.4453
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.017 0.0164
Brugia malayi nuclear hormone receptor family member odr-7 0.0118 0.3215 0.321
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0297 0.029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0251 0.7153 0.7152
Brugia malayi orphan nuclear receptor NR2E1 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0034 0.0717 0.0711
Loa Loa (eye worm) nuclear hormone receptor 0.0118 0.3215 0.321
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0356 0.0349
Loa Loa (eye worm) hypothetical protein 0.0133 0.3637 0.3632
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0591 0.0584
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0251 0.7153 0.7152
Brugia malayi photoreceptor-specific nuclear receptor 0.0251 0.7153 0.7152
Echinococcus granulosus nervana 2 0.002 0.029 0.0284
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0356 0.0349
Onchocerca volvulus 0.0251 0.7153 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0251 0.7153 1
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.029 0.0284
Loa Loa (eye worm) hypothetical protein 0.0133 0.3637 0.3632
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1189 0.1183
Echinococcus granulosus nuclear receptor nhr 48 0.0118 0.3215 0.321
Echinococcus multilocularis nervana 2 0.002 0.029 0.0284
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0118 0.3215 0.321
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0251 0.7153 0.7152
Brugia malayi nuclear hormone receptor 0.0118 0.3215 0.321
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0297 0.029
Echinococcus granulosus Nuclear hormone receptor HR96 0.0118 0.3215 0.321
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.017 0.0163
Trichomonas vaginalis set domain proteins, putative 0.0238 0.678 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0032 0.0658 1
Schistosoma mansoni RAR-like nuclear receptor 0.0251 0.7153 0.7152
Brugia malayi nuclear hormone receptor 0.0251 0.7153 0.7152
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0591 0.0584
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0251 0.7153 0.7152
Plasmodium vivax SET domain protein, putative 0.003 0.0591 1
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0133 0.3637 0.3632
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0356 1
Loa Loa (eye worm) DR-78 0.0118 0.3215 0.321
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0251 0.7153 0.7152
Echinococcus granulosus thyroid hormone receptor alpha 0.0118 0.3215 0.321
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0133 0.3637 0.3632
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0251 0.7153 0.7152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0251 0.7153 0.7152
Echinococcus granulosus Nuclear hormone receptor HR96 0.0118 0.3215 0.321
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0133 0.3637 0.3632
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1189 0.1183
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.017 0.0164
Echinococcus multilocularis GPCR, family 2 0.0016 0.017 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0251 0.7153 0.7152
Echinococcus granulosus nervana 2 0.002 0.029 0.0284
Loa Loa (eye worm) hypothetical protein 0.005 0.1189 0.1183
Giardia lamblia Kinase, AGC PKA 0.002 0.0297 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0251 0.7153 0.7152
Echinococcus granulosus geminin 0.034 0.9806 0.9806
Brugia malayi nuclear receptor RXR 0.0118 0.3215 0.321
Schistosoma mansoni thyroid hormone receptor 0.0251 0.7153 0.7152
Echinococcus granulosus GPCR family 2 0.0016 0.017 0.0163
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0251 0.7153 0.7152
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0118 0.3215 0.321
Onchocerca volvulus Protein ultraspiracle homolog 0.0251 0.7153 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0251 0.7153 0.7152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0251 0.7153 0.7152
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0347 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0356 0.0349
Echinococcus granulosus ecdysone induced protein 78C 0.0251 0.7153 0.7152
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0251 0.7153 0.7152
Schistosoma mansoni hypothetical protein 0.0034 0.0717 0.0711
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0658 0.0652
Brugia malayi MH2 domain containing protein 0.012 0.325 0.3246
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0251 0.7153 0.7152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0251 0.7153 0.7152
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.3637 0.3632
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0251 0.7153 0.7152
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0251 0.7153 0.7152
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0356 0.0349
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0356 0.5363
Toxoplasma gondii AGC kinase 0.003 0.0599 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.029 0.0284
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0251 0.7153 0.7152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.017 0.0164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.017 0.0163
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0118 0.3215 0.321
Brugia malayi nuclear receptor RXR 0.0133 0.3637 0.3632
Brugia malayi ecdysteroid receptor 0.0251 0.7153 0.7152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.017 0.0164
Schistosoma mansoni nuclear receptor 0.0118 0.3215 0.321
Schistosoma mansoni nuclear hormone receptor 0.0251 0.7153 0.7152
Brugia malayi nuclear receptor NHR-67 0.0118 0.3215 0.321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0251 0.7153 0.7152
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.325 0.3246
Echinococcus multilocularis FTZ F1 alpha 0.0251 0.7153 0.7152
Echinococcus multilocularis geminin 0.034 0.9806 0.9806
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0118 0.3215 0.321
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0591 0.0584
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.003 0.0591 0.0584
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.002 0.0297 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0347 1 1
Brugia malayi Protein kinase domain containing protein 0.0032 0.0658 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0251 0.7153 0.7152
Brugia malayi Pre-SET motif family protein 0.0209 0.5921 0.5918
Brugia malayi Nuclear hormone receptor E75 0.0118 0.3215 0.321
Brugia malayi hypothetical protein 0.0118 0.3215 0.321
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0251 0.7153 0.7152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0591 0.0584
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.017 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0591 0.0584
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0251 0.7153 0.7152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.017 0.0164
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0118 0.3215 0.321
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.017 0.0163
Onchocerca volvulus 0.0118 0.3215 0.3999
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Brugia malayi isocitrate dehydrogenase 0.0016 0.017 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1189 0.1183
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Echinococcus granulosus FTZ F1 alpha 0.0251 0.7153 0.7152
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.017 0.0164
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0347 1 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0251 0.7153 0.7152
Schistosoma mansoni retinoic acid receptor RXR 0.0251 0.7153 0.7152
Schistosoma mansoni nuclear hormone receptor 0.0118 0.3215 0.321
Brugia malayi Latrophilin receptor protein 2 0.0016 0.017 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0251 0.7153 0.7152
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0133 0.3637 0.3632
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.0163
Loa Loa (eye worm) nuclear receptor NHR-67 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Brugia malayi conserved hypotetical protein 0.0118 0.3215 0.321
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0118 0.3215 0.3999
Brugia malayi Nuclear hormone receptor-like 1 0.0133 0.3637 0.3632
Loa Loa (eye worm) hypothetical protein 0.0133 0.3637 0.3632
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0133 0.3637 0.3632
Schistosoma mansoni hypothetical protein 0.034 0.9806 0.9806
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.017 0.0164
Trichomonas vaginalis AGC family protein kinase 0.001 0.0007 0.001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0558 0.0551
Brugia malayi steroid hormone receptor 0.0251 0.7153 0.7152
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0591 0.0584
Echinococcus multilocularis nervana 2 0.002 0.029 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0066 0.0097
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0591 0.0584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0118 0.3215 0.321
Entamoeba histolytica protein kinase, putative 0.0032 0.0658 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.017 0.0163
Brugia malayi Pre-SET motif family protein 0.003 0.0591 0.0584
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.017 0.5
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0599 0.0592
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0118 0.3215 0.321
Onchocerca volvulus 0.0118 0.3215 0.3999
Brugia malayi hypothetical protein 0.0133 0.3637 0.3632
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Schistosoma mansoni nuclear receptor 0.0118 0.3215 0.321
Onchocerca volvulus 0.0238 0.678 0.9431
Schistosoma mansoni nuclear hormone receptor 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Schistosoma mansoni nuclear receptor nhr-48 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Schistosoma mansoni steroid hormone receptor ad4bp 0.0251 0.7153 0.7152
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.029 0.0284
Entamoeba histolytica protein kinase, putative 0.0032 0.0658 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0118 0.3215 0.321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0251 0.7153 0.7152
Echinococcus multilocularis nuclear receptor nhr 48 0.0118 0.3215 0.321
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.002 0.0297 0.3004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0251 0.7153 0.7152
Loa Loa (eye worm) hypothetical protein 0.0133 0.3637 0.3632
Loa Loa (eye worm) hypothetical protein 0.0133 0.3637 0.3632
Trypanosoma cruzi rac serine-threonine kinase, putative 0.002 0.0297 0.6805
Loa Loa (eye worm) steroid hormone receptor 0.0251 0.7153 0.7152
Brugia malayi Nuclear hormone receptor E75 0.0118 0.3215 0.321
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0599 0.0592
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Trichomonas vaginalis AGC family protein kinase 0.001 0.0007 0.001
Brugia malayi nuclear receptor NHR-88 0.0118 0.3215 0.321
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0251 0.7153 0.7152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0251 0.7153 0.7152
Entamoeba histolytica protein kinase, putative 0.003 0.0599 0.909
Brugia malayi nuclear hormone receptor family member nhr-6 0.0118 0.3215 0.321
Brugia malayi Isocitrate dehydrogenase 0.0016 0.017 0.0164
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.017 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0251 0.7153 0.7152
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.029 0.0284
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0717 0.0711
Schistosoma mansoni thyroid hormone receptor 0.0251 0.7153 0.7152
Brugia malayi tailless protein 0.0118 0.3215 0.321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0251 0.7153 0.7152
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0251 0.7153 0.7152
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0658 0.097
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0251 0.7153 0.7152
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0356 0.5363
Schistosoma mansoni zinc finger protein 0.0118 0.3215 0.321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0118 0.3215 0.321
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.017 0.0163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.017 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0251 0.7153 0.7152
Brugia malayi hypothetical protein 0.0133 0.3637 0.3632
Loa Loa (eye worm) hypothetical protein 0.0251 0.7153 0.7152
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.5921 0.5918
Brugia malayi hypothetical protein 0.0118 0.3215 0.321
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Onchocerca volvulus Bile acid receptor homolog 0.0251 0.7153 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0118 0.3215 0.3999
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0251 0.7153 0.7152
Loa Loa (eye worm) hypothetical protein 0.0118 0.3215 0.321
Echinococcus multilocularis ecdysone induced protein 78C 0.0251 0.7153 0.7152
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0251 0.7153 0.7152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0251 0.7153 0.7152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0251 0.7153 0.7152
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0297 0.029
Trypanosoma cruzi Protein kinase B 0.0022 0.0356 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 12.3 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 0.1 uM after 30 mins ChEMBL. 17583514
Activity (functional) = 13.2 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 1 uM after 30 mins ChEMBL. 17583514
Activity (functional) = 14 pg/microg/hr Effect on glucose-dependent insulin secretion activity per ug of total protein in rat RIN5F cells at 10 uM after 30 mins ChEMBL. 17583514

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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