Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | chemokine (C-C motif) receptor 4 | 360 aa | 316 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0049 | 0.0271 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0049 | 0.0271 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1911 | 0.2737 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0381 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0233 | 0.5648 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0049 | 0.0271 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.3193 | 0.3431 | |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0128 | 0.2579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1911 | 0.2737 |
Onchocerca volvulus | Matrilysin homolog | 0.0233 | 0.5648 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0049 | 0.0271 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0049 | 0.0271 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0049 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2579 | 0.3853 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0049 | 0.0271 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0049 | 0.0271 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0233 | 0.5648 | 0.8976 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0049 | 0.0271 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0049 | 0.0271 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0254 | 0.6262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1911 | 0.2737 |
Echinococcus multilocularis | 0.0049 | 0.0271 | 0.0271 | |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0095 | 0.1615 | 0.2243 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0105 | 0.1911 | 0.2737 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0128 | 0.2579 | 1 |
Brugia malayi | Matrixin family protein | 0.0254 | 0.6262 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0128 | 0.2579 | 0.3853 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0049 | 0.0271 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0105 | 0.1911 | 0.2737 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.3193 | 0.5209 |
Schistosoma mansoni | cytochrome P450 | 0.0049 | 0.0271 | 0.0442 |
Brugia malayi | Matrixin family protein | 0.0105 | 0.1911 | 0.2737 |
Leishmania major | cytochrome p450-like protein | 0.0049 | 0.0271 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0105 | 0.1911 | 0.2737 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0105 | 0.1911 | 0.3117 |
Brugia malayi | Matrixin family protein | 0.0105 | 0.1911 | 0.2737 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0049 | 0.0271 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0128 | 0.2579 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0249 | 0.613 | 1 |
Brugia malayi | Hemopexin family protein | 0.0149 | 0.3193 | 0.4878 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0271 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1615 | 0.2243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10 uM | Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells coexpressing Galpha16 by FLIPR assay | ChEMBL. | 17395464 |
Ki (binding) | > 10 uM | Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells coexpressing Galpha16 by FLIPR assay | ChEMBL. | 17395464 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.