Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0345 | 0.0484 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0098 | 0.3055 | 0.4292 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0819 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0774 | 0.0149 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0819 | 0.115 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0345 | 0.117 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0345 | 0.1128 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2946 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0774 | 0.0149 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0345 | 0.0484 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0774 | 0.1088 |
Echinococcus granulosus | lamin | 0.0032 | 0.0345 | 0.0484 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0345 | 0.117 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0774 | 0.2535 |
Onchocerca volvulus | 0.0042 | 0.0774 | 0.3523 | |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.712 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0774 | 0.1088 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0774 | 0.2629 |
Schistosoma mansoni | lamin | 0.0032 | 0.0345 | 0.0484 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0819 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0819 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0819 | 0.115 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0774 | 0.2629 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0774 | 0.1088 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0774 | 0.2629 |
Onchocerca volvulus | 0.0032 | 0.0345 | 0.1569 | |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0819 | 0.115 |
Echinococcus granulosus | jun protein | 0.0098 | 0.3055 | 0.4292 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0819 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0774 | 0.2629 |
Schistosoma mansoni | lipoxygenase | 0.0097 | 0.2983 | 0.419 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0774 | 0.0149 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0774 | 0.1088 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0774 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0774 | 0.2629 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0774 | 0.2535 |
Schistosoma mansoni | lipoxygenase | 0.0138 | 0.467 | 0.656 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0321 | 0.1091 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0345 | 0.0484 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.0819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0774 | 0.2629 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0774 | 0.0149 |
Onchocerca volvulus | 0.0032 | 0.0345 | 0.1569 | |
Brugia malayi | hypothetical protein | 0.0077 | 0.2198 | 0.7194 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0774 | 0.0149 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0138 | 0.467 | 0.656 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.0819 | 0.2779 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0774 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0098 | 0.3055 | 0.4292 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0819 | 1 |
Onchocerca volvulus | 0.0077 | 0.2198 | 1 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0345 | 0.117 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0819 | 1 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0345 | 0.1128 |
Onchocerca volvulus | 0.0042 | 0.0774 | 0.3523 | |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0774 | 0.2629 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0345 | 0.0484 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0774 | 0.0149 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0345 | 0.0484 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0819 | 0.268 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0819 | 0.115 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.0819 | 1 |
Echinococcus multilocularis | geminin | 0.0198 | 0.712 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.0345 | 0.0484 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0774 | 0.0149 |
Onchocerca volvulus | 0.0042 | 0.0774 | 0.3523 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0138 | 0.467 | 0.656 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0774 | 0.0149 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0774 | 0.0149 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0774 | 0.2535 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2307 | 0.3241 |
Echinococcus multilocularis | jun protein | 0.0098 | 0.3055 | 0.4292 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0774 | 0.2535 |
Schistosoma mansoni | jun-related protein | 0.008 | 0.2307 | 0.3241 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0819 | 0.5 |
Echinococcus granulosus | geminin | 0.0198 | 0.712 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0774 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0098 | 0.3055 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.712 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0774 | 0.2629 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0345 | 0.0484 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 76 nmol/g | Drug activation in rat hepatocytes by measuring intracellular NMPA levels at 100 uM after 1 hr | ChEMBL. | 17459701 |
Activity (ADMET) | = 0 pmol/min/mg | Drug activation in human liver microsomes assessed as rate of NMPA formation | ChEMBL. | 17459701 |
Activity (ADMET) | = 0 pmol/min/mg | Drug activation in NADPH-fortified rat liver without microsomes assessed as rate of NMPA formation | ChEMBL. | 17459701 |
Activity (ADMET) | = 2.76 pmol/min/mg | Drug activation in NADPH-fortified rat liver microsomes assessed as rate of NMPA formation | ChEMBL. | 17459701 |
Activity (ADMET) | = 4.85 pmol/min/mg | Drug activation in NADPH-fortified human liver microsomes assessed as rate of NMPA formation | ChEMBL. | 17459701 |
Ratio (ADMET) | = 2 | Ratio of drug activation in NADPH-fortified human liver microsomes to NADPH-fortified rat liver microsomes assessed as rate of NMPA formation | ChEMBL. | 17459701 |
t1/2 (ADMET) | > 120 min | Stability assessed as half life in rat plasma | ChEMBL. | 17459701 |
t1/2 | > 120 min | Stability assessed as half life in Krebs bicarbonate buffer at 37degC | ChEMBL. | 17459701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.