Detailed information for compound 46070

Basic information

Technical information
  • TDR Targets ID: 46070
  • Name: (1S,3R,4R,5R)-1-[3-(4-chlorophenyl)propoxy]-3 ,4-dihydroxy-5-(4-phenylthiadiazole-5-carbony l)oxycyclohexane-1-carboxylic acid
  • MW: 532.993 | Formula: C25H25ClN2O7S
  • H donors: 3 H acceptors: 7 LogP: 3.85 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1[C@H](OC(=O)c2snnc2c2ccccc2)C[C@](C[C@H]1O)(OCCCc1ccc(cc1)Cl)C(=O)O
  • InChi: 1S/C25H25ClN2O7S/c26-17-10-8-15(9-11-17)5-4-12-34-25(24(32)33)13-18(29)21(30)19(14-25)35-23(31)22-20(27-28-36-22)16-6-2-1-3-7-16/h1-3,6-11,18-19,21,29-30H,4-5,12-14H2,(H,32,33)/t18-,19-,21-,25+/m1/s1
  • InChiKey: WJKBWVYTVHLQSX-JDFHOKRYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S,3R,4R,5R)-1-[3-(4-chlorophenyl)propoxy]-3,4-dihydroxy-5-(4-phenylthiadiazole-5-carbonyl)oxy-cyclohexanecarboxylic acid
  • (1S,3R,4R,5R)-1-[3-(4-chlorophenyl)propoxy]-3,4-dihydroxy-5-[oxo-(4-phenyl-5-thiadiazolyl)methoxy]cyclohexanecarboxylic acid
  • (1S,3R,4R,5R)-1-[3-(4-chlorophenyl)propoxy]-3,4-dihydroxy-5-[(4-phenyl-1,2,3-thiadiazol-5-yl)carbonyloxy]cyclohexane-1-carboxylic acid
  • (1S,3R,4R,5R)-1-[3-(4-chlorophenyl)propoxy]-3,4-dihydroxy-5-(4-phenylthiadiazole-5-carbonyl)oxy-cyclohexane-1-carboxylic acid
  • (1S,3R,4R,5R)-1-[3-(4-chlorophenyl)propoxy]-3,4-dihydroxy-5-[oxo-(4-phenyl-5-thiadiazolyl)methoxy]-1-cyclohexanecarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi sulfakinin receptor protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) fibroinase 0.0091 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0143 0.101 0.101
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.0372 0.241
Echinococcus granulosus g protein coupled receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclins, putative 0.0093 0.0397 0.0687
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0083 0.0276 0.0276
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Mycobacterium leprae probable zinc metalloprotease 0.0189 0.1578 0.5
Onchocerca volvulus 0.0083 0.0276 0.0361
Loa Loa (eye worm) hypothetical protein 0.0189 0.1578 0.1578
Echinococcus granulosus somatostatin receptor 0.0083 0.0276 0.0276
Echinococcus granulosus cyclins 0.0093 0.0397 0.0397
Trypanosoma brucei telomerase reverse transcriptase 0.0186 0.1542 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Onchocerca volvulus 0.0083 0.0276 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Echinococcus multilocularis aminopeptidase N 0.012 0.0728 0.0591
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Brugia malayi Myb-like DNA-binding domain containing protein 0.0171 0.1354 0.1354
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0276 0.0276
Brugia malayi Cathepsin L-like precursor 0.0091 0.0372 0.0372
Loa Loa (eye worm) ctsf protein 0.0091 0.0372 0.0372
Onchocerca volvulus Cathepsin L homolog 0.0091 0.0372 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Echinococcus granulosus cyclin B 0.0149 0.1087 0.1087
Loa Loa (eye worm) hypothetical protein 0.0143 0.101 0.101
Onchocerca volvulus 0.0149 0.1087 0.142
Entamoeba histolytica cyclin, putative 0.0149 0.1087 1
Trichomonas vaginalis cyclins, putative 0.0149 0.1087 0.1879
Onchocerca volvulus 0.0091 0.0372 0.0486
Onchocerca volvulus 0.0083 0.0276 0.0361
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Giardia lamblia G2/mitotic-specific cyclin B 0.0149 0.1087 0.2423
Loa Loa (eye worm) cysteine protease 0.0091 0.0372 0.0372
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0221 0.1978 0.1978
Onchocerca volvulus 0.0094 0.0402 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni opsin-like receptor 0.0083 0.0276 0.0276
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.0372 0.3421
Echinococcus granulosus neuropeptide receptor 0.0237 0.2169 0.2169
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus serotonin receptor 0.0083 0.0276 0.0276
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.0372 0.0125
Trichomonas vaginalis cyclins, putative 0.0149 0.1087 0.1879
Schistosoma mansoni hypothetical protein 0.0083 0.0276 0.0276
Echinococcus multilocularis 0.0703 0.792 1
Toxoplasma gondii cathepsin CPL 0.0091 0.0372 0.1728
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0397 0.0687
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.0372 0.3421
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni amine GPCR 0.0083 0.0276 0.0276
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.0372 0.0372
Echinococcus granulosus g protein coupled receptor 0.0083 0.0276 0.0276
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0276 0.0276
Brugia malayi larval opioid receptor 0.0083 0.0276 0.0276
Entamoeba histolytica cyclin family protein 0.0093 0.0397 0.3655
Entamoeba histolytica cyclin family protein 0.0093 0.0397 0.3655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Loa Loa (eye worm) melatonin receptor type 1A 0.0083 0.0276 0.0276
Brugia malayi Dopamine receptor protein 2 0.0083 0.0276 0.0276
Onchocerca volvulus Cathepsin F homolog 0.0091 0.0372 0.0486
Brugia malayi Tachykinin-like peptides receptor 99D 0.0523 0.5696 0.5696
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0085 0.0292 0.0292
Trichomonas vaginalis cyclin B3, putative 0.0093 0.0397 0.0687
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0169 0.1327 0.2295
Onchocerca volvulus 0.0083 0.0276 0.0361
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclin B, putative 0.0149 0.1087 0.1879
Loa Loa (eye worm) TYRA-2 protein 0.0083 0.0276 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0276 0.0276
Giardia lamblia Telomerase catalytic subunit 0.0186 0.1542 0.4024
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus multilocularis neuropeptide receptor 0.0237 0.2169 0.2476
Loa Loa (eye worm) hypothetical protein 0.0189 0.1578 0.1578
Brugia malayi ORL1-like opioid receptor 0.0083 0.0276 0.0276
Echinococcus granulosus cathepsin l cysteine peptidase 0.0091 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.053 0.5782 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni neuropeptide receptor 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0221 0.1978 0.2586
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.0372 0.241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Echinococcus granulosus furin 0.0872 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Echinococcus multilocularis cyclin B 0.0149 0.1087 0.106
Onchocerca volvulus 0.012 0.0728 0.0952
Echinococcus granulosus tachykinin peptides receptor 99D 0.0083 0.0276 0.0276
Echinococcus granulosus G protein coupled receptor 139 0.0083 0.0276 0.0276
Brugia malayi neuroendocrine convertase 1 precursor 0.0548 0.6004 0.6004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0083 0.0276 0.0276
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0083 0.0276 0.0276
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0083 0.0276 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni hypothetical protein 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0095 0.0423 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1787 0.309
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1787 0.309
Leishmania major telomerase reverse transcriptase, putative 0.0186 0.1542 1
Brugia malayi RE15519p 0.0083 0.0276 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0108 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.014 0.097 0.097
Schistosoma mansoni amine GPCR 0.0083 0.0276 0.0276
Loa Loa (eye worm) proprotein convertase 2 0.0206 0.1787 0.1787
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni opsin-like receptor 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclins, putative 0.0149 0.1087 0.1879
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Echinococcus multilocularis cyclin B3 1 0.0093 0.0397 0.0158
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0276 0.0276
Echinococcus granulosus cyclins 0.0093 0.0397 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0276 0.0276
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0189 0.1578 0.5
Echinococcus granulosus Furin 1 0.0206 0.1787 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Echinococcus granulosus sex peptide receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) endoprotease bli-4 0.0872 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0276 0.0276
Schistosoma mansoni hypothetical protein 0.0169 0.1327 0.1327
Onchocerca volvulus Cathepsin L homolog 0.0091 0.0372 0.0486
Plasmodium falciparum cyclin 0.0093 0.0397 0.0218
Brugia malayi Serotonin receptor 0.0083 0.0276 0.0276
Echinococcus granulosus cathepsin l1 0.0091 0.0372 0.0372
Trichomonas vaginalis hypothetical protein 0.0169 0.1327 0.2295
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0276 0.0276
Schistosoma mansoni growth hormone secretagogue receptor 0.0083 0.0276 0.0276
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0276 0.0276
Echinococcus granulosus cyclins 0.0093 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni histamine h1 receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0523 0.5696 0.5696
Echinococcus granulosus fmrfamide receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0872 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Echinococcus granulosus 7TM GPCR rhodopsin 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclin B, putative 0.0093 0.0397 0.0687
Brugia malayi AKH receptor 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0091 0.0372 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1787 0.309
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Echinococcus granulosus neuropeptide s receptor 0.0083 0.0276 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0091 0.0372 0.0486
Echinococcus granulosus g-protein coupled receptor 0.0083 0.0276 0.0276
Brugia malayi neuropeptide F receptor 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0276 0.0276
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.0372 0.0372
Schistosoma mansoni neuropeptide f receptor 76f 0.0083 0.0276 0.0276
Echinococcus granulosus hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus cyclin b3 0.0093 0.0397 0.0397
Echinococcus granulosus alpha 1A adrenergic receptor 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni furin-1 (S08 family) 0.0379 0.3924 0.3924
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0276 0.0276
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.014 0.097 0.097
Onchocerca volvulus 0.0091 0.0372 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni neuropeptide receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) peptidase family M1 containing protein 0.0097 0.0445 0.0445
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Echinococcus granulosus neuroendocrine convertase 2 0.0548 0.6004 0.6004
Trichomonas vaginalis cyclin D, putative 0.0093 0.0397 0.0687
Brugia malayi G protein-coupled receptor 0.0083 0.0276 0.0276
Entamoeba histolytica cyclin, putative 0.0093 0.0397 0.3655
Echinococcus multilocularis G protein coupled receptor 139 0.0237 0.2169 0.2476
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0276 0.0276
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.0372 0.0125
Brugia malayi SWIRM domain containing protein 0.0221 0.1978 0.1978
Onchocerca volvulus Neuropeptide F receptor homolog 0.0083 0.0276 0.0361
Brugia malayi celfurPC protein 0.0703 0.792 0.792
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0169 0.1327 0.2295
Loa Loa (eye worm) hypothetical protein 0.0149 0.1087 0.1087
Brugia malayi putative neuropeptide receptor NPR1 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0204 0.1765 0.1765
Schistosoma mansoni cyclins 0.0093 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0186 0.1542 1
Brugia malayi Dopamine receptor protein 1 0.0083 0.0276 0.0276
Brugia malayi putative neuropeptide receptor 0.0083 0.0276 0.0276
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Trypanosoma cruzi cyclin, putative 0.0149 0.1087 0.7045
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.0372 0.241
Echinococcus granulosus allatostatin A receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0091 0.0372 0.0372
Echinococcus multilocularis cysteine protease 0.0091 0.0372 0.0125
Schistosoma mansoni biogenic amine receptor 0.0083 0.0276 0.0276
Brugia malayi Cathepsin L-like precursor 0.0091 0.0372 0.0372
Echinococcus granulosus cyclins 0.0093 0.0397 0.0397
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.0372 0.0643
Onchocerca volvulus 0.0083 0.0276 0.0361
Brugia malayi Cyclin, N-terminal domain containing protein 0.0149 0.1087 0.1087
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.0372 0.241
Brugia malayi Cyclin, N-terminal domain containing protein 0.0093 0.0397 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Echinococcus multilocularis neuropeptide FF receptor 2 0.0523 0.5696 0.7091
Schistosoma mansoni myosin xvIII 0.0083 0.0276 0.0276
Echinococcus granulosus cyclins 0.0093 0.0397 0.0397
Trypanosoma brucei mitotic cyclin 6 0.0149 0.1087 0.6106
Brugia malayi G-protein coupled receptor 0.0083 0.0276 0.0276
Trypanosoma cruzi cyclin 6, putative 0.0149 0.1087 0.7045
Trichomonas vaginalis cyclins, putative 0.0078 0.0214 0.037
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclin B, putative 0.0149 0.1087 0.1879
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0091 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus neuropeptide receptor A26 0.0083 0.0276 0.0276
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0095 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.014 0.097 0.097
Schistosoma mansoni neuropeptide receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni opsin-like receptor 0.0083 0.0276 0.0276
Schistosoma mansoni amine GPCR 0.0083 0.0276 0.0276
Leishmania major cyclin 0.0149 0.1087 0.6106
Brugia malayi Cathepsin L-like precursor 0.0091 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0094 0.0402 0.0402
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Schistosoma mansoni biogenic amine receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Onchocerca volvulus 0.0083 0.0276 0.0361
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0083 0.0276 0.0361
Echinococcus multilocularis endothelin converting enzyme 1 0.0189 0.1578 0.1703
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Brugia malayi Cathepsin L-like precursor 0.0091 0.0372 0.0372
Brugia malayi Serotonin receptor 0.0083 0.0276 0.0276
Toxoplasma gondii peptidase family M13 protein 0.0189 0.1578 1
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0276 0.0276
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.0423 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0276 0.0276
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni cyclin B3 0.0093 0.0397 0.0397
Echinococcus multilocularis cyclin b3 0.0093 0.0397 0.0158
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.0423 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Entamoeba histolytica cysteine protease, putative 0.0091 0.0372 0.3421
Onchocerca volvulus 0.0091 0.0372 0.0486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0189 0.1578 0.1578
Brugia malayi G-protein coupled receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0143 0.101 0.101
Brugia malayi Peptidase family M13 containing protein 0.0189 0.1578 0.1578
Loa Loa (eye worm) hypothetical protein 0.0204 0.1765 0.1765
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0276 0.0276
Schistosoma mansoni neuropeptide receptor 0.0237 0.2169 0.2169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Brugia malayi neuropeptide F receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0204 0.1765 0.1765
Loa Loa (eye worm) peptidase family M13 containing protein 0.014 0.097 0.097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.0372 0.0125
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0186 0.1542 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0091 0.0372 0.0372
Giardia lamblia Furin precursor putative serine protease 0.0169 0.1327 0.3268
Loa Loa (eye worm) hypothetical protein 0.0143 0.101 0.101
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0276 0.0276
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0083 0.0276 0.0276
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus aminopeptidase N 0.012 0.0728 0.0728
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Brugia malayi Peptidase family M1 containing protein 0.012 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1787 0.309
Brugia malayi Cathepsin L-like precursor 0.0091 0.0372 0.0372
Trichomonas vaginalis cyclin B, putative 0.0149 0.1087 0.1879
Trypanosoma cruzi CYC2-like cyclin, putative 0.0149 0.1087 0.7045
Loa Loa (eye worm) hypothetical protein 0.0149 0.1087 0.1087
Echinococcus granulosus peptide allatostatin:somatostatin 0.0083 0.0276 0.0276
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.0276 0.0276
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0143 0.101 0.101
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0149 0.1087 0.6106
Toxoplasma gondii RNA-directed DNA polymerase 0.0186 0.1542 0.9755
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1787 0.309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0093 0.0397 0.0158
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0083 0.0276 0.0276
Brugia malayi Cathepsin L-like precursor 0.0091 0.0372 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Onchocerca volvulus 0.0083 0.0276 0.0361
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Echinococcus multilocularis Furin 1 0.0206 0.1787 0.1976
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Trichomonas vaginalis cyclin B, putative 0.0149 0.1087 0.1879
Echinococcus granulosus dro:myosuppressin receptor 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclin A, putative 0.0149 0.1087 0.1879
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0276 0.0276
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0276 0.0276
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0083 0.0276 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Echinococcus granulosus g protein coupled receptor 0.0083 0.0276 0.0276
Giardia lamblia High cysteine membrane protein Group 2 0.0324 0.3243 1
Schistosoma mansoni hypothetical protein 0.0083 0.0276 0.0276
Brugia malayi Dopamine receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) cyclin domain-containing protein 0.0093 0.0397 0.0397
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0189 0.1578 0.1578
Loa Loa (eye worm) hypothetical protein 0.0143 0.101 0.101
Onchocerca volvulus 0.0083 0.0276 0.0361
Echinococcus granulosus neuropeptide FF receptor 2 0.0523 0.5696 0.5696
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0342 0.3465 0.3465
Brugia malayi GnHR receptor homolog 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0083 0.0276 0.0361
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.0276 0.0276
Schistosoma mansoni alpha-1 adrenergic receptor 0.0083 0.0276 0.0276
Echinococcus granulosus 7tm_1 domain containing protein 0.0083 0.0276 0.0276
Echinococcus granulosus neuropeptide receptor 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0091 0.0372 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0083 0.0276 0.0276
Brugia malayi Cyclin, N-terminal domain containing protein 0.0149 0.1087 0.1087
Loa Loa (eye worm) peptidase family M13 containing protein 0.014 0.097 0.097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0276 0.0276
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0083 0.0276 0.0276
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0083 0.0276 0.0276
Echinococcus multilocularis cysteine protease 0.0091 0.0372 0.0125
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0682 0.765 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0204 0.1765 0.1947
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.0276 0.0276
Schistosoma mansoni adenoreceptor 0.0083 0.0276 0.0276
Trypanosoma cruzi cyclin, putative 0.0149 0.1087 0.7045
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Schistosoma mansoni biogenic amine receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0176 0.1416 0.1416
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1327 0.2295
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.053 0.5782 0.7203
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.014 0.097 0.097
Onchocerca volvulus 0.0083 0.0276 0.0361
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0169 0.1327 0.2295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.0372 0.0643
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0093 0.0397 0.0397
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0276 0.0276
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0083 0.0276 0.0276
Schistosoma mansoni neprilysin-2 (M13 family) 0.0095 0.0423 0.0423
Echinococcus granulosus cathepsin L cysteine proteinase 0.0091 0.0372 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Loa Loa (eye worm) hypothetical protein 0.0171 0.1354 0.1354
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.053 0.5782 1
Schistosoma mansoni amine GPCR 0.0083 0.0276 0.0276
Echinococcus granulosus cyclin B3 1 0.0093 0.0397 0.0397
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0276 0.0276
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus multilocularis cyclins 0.0093 0.0397 0.0158
Plasmodium vivax telomerase reverse transcriptase, putative 0.0186 0.1542 1
Echinococcus granulosus orexin receptor type 2 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclins, putative 0.0149 0.1087 0.1879
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Plasmodium falciparum telomerase reverse transcriptase 0.0186 0.1542 1
Schistosoma mansoni amine GPCR 0.0083 0.0276 0.0276
Schistosoma mansoni cyclin B 0.0149 0.1087 0.1087
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.053 0.5782 0.5782
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Brugia malayi Melatonin receptor type 1A 0.0083 0.0276 0.0276
Trichomonas vaginalis cyclin D, putative 0.0093 0.0397 0.0687
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0206 0.1787 0.1787
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0083 0.0276 0.0276
Trypanosoma cruzi cruzipain precursor, putative 0.0091 0.0372 0.241
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0083 0.0276 0.0276
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0083 0.0276 0.0276
Onchocerca volvulus 0.0091 0.0372 0.0486
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Onchocerca volvulus CoRest homolog 0.0176 0.1416 0.1851
Echinococcus granulosus lysine specific histone demethylase 1A 0.0204 0.1765 0.1765
Onchocerca volvulus 0.0083 0.0276 0.0361
Echinococcus multilocularis neuroendocrine convertase 2 0.0548 0.6004 0.7494
Brugia malayi Telomerase reverse transcriptase 0.0495 0.5355 0.5355
Brugia malayi hypothetical protein 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1787 0.309
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.0372 0.0125
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0276 0.0276
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0276 0.0276
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0083 0.0276 0.0276
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0872 1 1
Brugia malayi proprotein convertase 2 0.0548 0.6004 0.6004
Echinococcus granulosus endothelin converting enzyme 1 0.0189 0.1578 0.1578
Schistosoma mansoni hypothetical protein 0.0083 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0189 0.1578 0.1578
Brugia malayi follicle stimulating hormone receptor 0.0083 0.0276 0.0276
Mycobacterium ulcerans zinc metalloprotease 0.0189 0.1578 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643
Brugia malayi G protein-coupled receptor F59B2.13 0.0083 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.0372 0.0643

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.5 uM Inhibition glucose-6-phosphate hydrolysis in highly intact microsomal preparations obtained from livers of 20-h fasted rats. ChEMBL. 9003513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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