Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.000000030247 | 0.00000010407 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.0338 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0016 |
Echinococcus granulosus | jun protein | 0.0095 | 0.2906 | 0.4614 |
Onchocerca volvulus | 0.0075 | 0.217 | 1 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.0338 | 0.0338 |
Brugia malayi | hypothetical protein | 0.0075 | 0.217 | 0.7467 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.0338 | 0.0536 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.1209 | 0.416 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.0338 | 0.0536 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0095 | 0.2906 | 0.4614 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0189 | 0.6299 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.5627 | 0.5627 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0.0338 | 0.0536 |
Brugia malayi | Death domain containing protein | 0.0014 | 0.000000030247 | 0.00000010407 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.0338 | 0.1162 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.0338 | 0.1201 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0338 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1209 | 0.4299 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.0338 | 0.1162 |
Echinococcus multilocularis | geminin | 0.0171 | 0.5627 | 0.8933 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.1209 | 0.4299 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.1449 | 0.1449 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.0338 | 0.1162 |
Brugia malayi | ecdysteroid receptor | 0.0024 | 0.0338 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.0338 | 0.0338 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.1209 | 0.1209 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.0338 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.5627 | 0.5627 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0.0338 | 0.1557 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.0338 | 0.1162 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.0338 | 0.0536 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.1209 | 0.5572 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.1209 | 0.416 |
Echinococcus multilocularis | jun protein | 0.0095 | 0.2906 | 0.4614 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0074 | 0.215 | 0.3414 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.0338 | 0.1162 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.0338 | 0.0338 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.0338 | 0.0338 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.0338 | 0.1162 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.0338 | 0.1162 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.1449 | 0.23 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.0338 | 0.1201 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.0338 | 0.1162 |
Onchocerca volvulus | 0.0024 | 0.0338 | 0.1557 | |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.1209 | 0.192 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.0338 | 0.1162 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.0338 | 0.0338 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.0338 | 0.1162 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0338 | 0.0536 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0014 | 0.000000030247 | 0.00000004802 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0.0338 | 0.1557 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0074 | 0.215 | 0.3414 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.0338 | 0.0536 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.0338 | 0.0536 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.0338 | 0.0338 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.1449 | 0.23 |
Brugia malayi | bZIP transcription factor family protein | 0.0095 | 0.2906 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0338 | 0.0536 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.0338 | 0.0536 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.0338 | 0.1201 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.2264 | 0.2264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.0338 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0.0338 | 0.1557 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.0338 | 0.0536 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.0338 | 0.1201 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0004 | 0.0007 |
Echinococcus granulosus | geminin | 0.0171 | 0.5627 | 0.8933 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.0338 | 0.1162 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0338 | 0.0536 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0189 | 0.6299 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.1209 | 0.192 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.1209 | 0.192 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.0338 | 0.0536 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.0338 | 0.1162 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.0338 | 0.1201 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.1209 | 0.1209 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0338 | 0.0338 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.0338 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1449 | 0.5151 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.1449 | 0.23 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0004 | 0.0004 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.0338 | 0.0536 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.1449 | 0.5151 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.0338 | 0.0536 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0095 | 0.2906 | 0.4614 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.0338 | 0.0338 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0338 | 0.0536 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.1449 | 0.23 |
Brugia malayi | Uncoordinated protein 44 | 0.0014 | 0.000000030247 | 0.00000010407 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.0338 | 0.1162 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.0338 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0338 | 0.0338 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.0338 | 0.1162 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0014 | 0.000000030247 | 0.00000004802 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.1209 | 0.1209 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0014 | 0.000000030247 | 0.000000030247 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.0338 | 0.1162 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.0338 | 0.0338 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.0338 | 0.1162 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.0338 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2812 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.0338 | 0.0536 |
Onchocerca volvulus | 0.0048 | 0.1209 | 0.5572 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0338 | 0.1201 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.0338 | 0.1162 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.0338 | 0.0338 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.1209 | 0.192 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0004 | 0.0007 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.0338 | 0.0536 |
Schistosoma mansoni | jun-related protein | 0.0077 | 0.2264 | 0.2264 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.1449 | 0.4985 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.0338 | 0.0536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.2 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, S. aureus (S-54K) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 0.2 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, S. aureus (ATCC90124) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 0.39 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, Proteus vulgaris (IID OX-19)was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 0.78 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, Proteus mirabilis (121K) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 3.13 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, E. coli (TH-13) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 3.13 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, E. coli (TH-397) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 3.13 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, E. coli (TH-13) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 3.13 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, E. coli (TH-397) was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
MIC (functional) | = 12.5 ug ml-1 | Growth inhibition against Beta lactamase producing bacteria, Serratia marcescens was determined for the compound in the combination with Ampicillin | ChEMBL. | 3039137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.