TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.152 | Formula: C7H10Cl2N2Pt++
H donors: 1 H acceptors: 0 LogP: 2.52 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Cl[Pt]1(Cl)[NH2+]CCc2[n+]1cccc2
InChi: 1S/C7H10N2.2ClH.Pt/c8-5-4-7-3-1-2-6-9-7;;;/h1-3,6H,4-5,8H2;2*1H;/q;;;+4/p-2
InChiKey: HVJDBENDVIDKHW-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Brugia malayi	Protein kinase domain containing protein	0.0157	0.0219	0.0508
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.006	0.0139
Onchocerca volvulus	Cathepsin L homolog	0.0606	0.2825	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.013	0.006	0.0139
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.013	0.006	0.0139
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Brugia malayi	Cathepsin L-like precursor	0.0606	0.2825	0.656
Brugia malayi	Cathepsin L-like precursor	0.0606	0.2825	0.656
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0606	0.2825	0.656
Echinococcus multilocularis	cysteine protease	0.0606	0.2825	0.6511
Onchocerca volvulus		0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Brugia malayi	Cathepsin L-like precursor	0.0606	0.2825	0.656
Loa Loa (eye worm)	cysteine protease	0.0606	0.2825	0.656
Echinococcus multilocularis	cathepsin L cysteine protease	0.0606	0.2825	0.6511
Giardia lamblia	Cathepsin B precursor	0.0356	0.1373	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0356	0.1373	0.475
Loa Loa (eye worm)	hypothetical protein	0.013	0.006	0.0139
Brugia malayi	Papain family cysteine protease containing protein	0.013	0.006	0.0139
Loa Loa (eye worm)	hypothetical protein	0.086	0.4307	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0193	0.0424	0.0984
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.013	0.006	0.0139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.086	0.4307	0.4272
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.1373	0.3189
Echinococcus granulosus	cathepsin l1	0.0606	0.2825	0.6511
Plasmodium vivax	unspecified product	0.0193	0.0424	0.1316
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.013	0.006	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Brugia malayi	Cathepsin L-like precursor	0.0413	0.1704	0.3957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0193	0.0424	0.0984
Brugia malayi	cathepsin Z-like cysteine proteinase	0.013	0.006	0.0139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0356	0.1373	0.1321
Entamoeba histolytica	cysteine proteinase 1, putative	0.0323	0.1181	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Leishmania major	cathepsin L-like protease	0.0606	0.2825	0.1683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Plasmodium vivax	vivapain-2	0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0413	0.1704	0.5946
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0606	0.2825	0.656
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0606	0.2825	1
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0606	0.2825	0.6511
Entamoeba histolytica	cysteine proteinase, putative	0.0323	0.1181	0.4054
Schistosoma mansoni	cathepsin D (A01 family)	0.014	0.012	0.0278
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0226	0.0616	0.1309
Brugia malayi	Papain family cysteine protease containing protein	0.013	0.006	0.0139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.013	0.006	0.0139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.013	0.006	0.0139
Giardia lamblia	Cathepsin B precursor	0.0356	0.1373	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.013	0.006	0.0139
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1646	0.8879	0.8872
Entamoeba histolytica	cysteine proteinase, putative	0.0606	0.2825	1
Plasmodium vivax	vivapain-2	0.0606	0.2825	1
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0606	0.2825	0.656
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.086	0.4307	1
Onchocerca volvulus		0.0606	0.2825	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0323	0.1181	0.2742
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.0234	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0413	0.1704	0.3957
Echinococcus multilocularis	cysteine protease	0.0606	0.2825	0.6511
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.086	0.4307	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0323	0.1181	0.1128
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Echinococcus granulosus	cysteine protease	0.0323	0.1181	0.264
Plasmodium vivax	vivapain-1	0.0323	0.1181	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.1839	1	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.006	0.0139
Plasmodium vivax	vivapain-3	0.0323	0.1181	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Schistosoma mansoni	cathepsin D (A01 family)	0.014	0.012	0.0278
Leishmania major	cathepsin L-like protease	0.0606	0.2825	0.1683
Brugia malayi	Cathepsin L-like precursor	0.0606	0.2825	0.656
Echinococcus granulosus	cathepsin b	0.086	0.4307	1
Schistosoma mansoni	cathepsin S (C01 family)	0.013	0.006	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.006	0.0139
Trypanosoma cruzi	cysteine peptidase, putative	0.0193	0.0424	0.0366
Loa Loa (eye worm)	cathepsin B	0.0356	0.1373	0.3189
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0424	0.0984
Brugia malayi	cathepsin B-like cysteine proteinase	0.086	0.4307	1
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0226	0.0616	0.143
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.013	0.006	0.0139
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Entamoeba histolytica	cysteine proteinase 2	0.0323	0.1181	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0606	0.2825	1
Entamoeba histolytica	cysteine protease, putative	0.0606	0.2825	1
Onchocerca volvulus		0.0413	0.1704	0.5946
Leishmania major	cysteine peptidase A (CPA)	0.0606	0.2825	0.1683
Schistosoma mansoni	cathepsin C	0.013	0.006	0.0139
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0323	0.1181	0.1128
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0323	0.1181	0.2742
Leishmania major	cathepsin L-like protease	0.0606	0.2825	0.1683
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.013	0.006	0.0139
Trypanosoma cruzi	major cysteine proteinase, putative	0.1364	0.7235	0.7218
Giardia lamblia	Cathepsin B precursor	0.0356	0.1373	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0606	0.2825	1
Toxoplasma gondii	cathepsin CPL	0.0606	0.2825	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0157	0.0219	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0219	0.0508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0356	0.1373	0.0218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0413	0.1704	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0323	0.1181	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.1839	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0606	0.2825	0.6511
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0413	0.1704	0.3957
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.013	0.006	0.0139
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0606	0.2825	0.656
Entamoeba histolytica	cysteine proteinase, putative	0.0606	0.2825	1
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0424	0.0984
Brugia malayi	Cathepsin L-like precursor	0.0413	0.1704	0.3957
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0424	0.0984
Entamoeba histolytica	cysteine proteinase, putative	0.0323	0.1181	0.4054
Onchocerca volvulus		0.0606	0.2825	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0193	0.0424	0.0366
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.086	0.4307	1
Onchocerca volvulus		0.0606	0.2825	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.006	0.0139
Brugia malayi	cathepsin F-like cysteine proteinase	0.013	0.006	0.0139
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0157	0.0219	0.0374
Brugia malayi	Cathepsin L-like precursor	0.0193	0.0424	0.0984
Entamoeba histolytica	cysteine proteinase, putative	0.0323	0.1181	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0616	0.143
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0606	0.2825	0.6511
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0413	0.1704	0.3957
Onchocerca volvulus	Cathepsin F homolog	0.0606	0.2825	1
Leishmania major	cathepsin L-like protease	0.0606	0.2825	0.1683
Schistosoma mansoni	cathepsin F (C01 family)	0.0606	0.2825	0.656
Loa Loa (eye worm)	fibroinase	0.0606	0.2825	0.656
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0226	0.0616	0.1309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.013	0.006	0.0139
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.013	0.006	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Leishmania major	cathepsin L-like protease	0.1839	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0323	0.1181	0.2742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1181	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Echinococcus multilocularis	cathepsin b	0.086	0.4307	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Echinococcus multilocularis	cathepsin L	0.0323	0.1181	0.264
Echinococcus granulosus	cathepsin L cysteine protease	0.0323	0.1181	0.264
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.013	0.006	0.0139
Brugia malayi	cathepsin L precursor	0.013	0.006	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Leishmania major	cathepsin L-like protease	0.0606	0.2825	0.1683
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.086	0.4307	1
Loa Loa (eye worm)	hypothetical protein	0.0413	0.1704	0.3957
Toxoplasma gondii	cathepsin B	0.0356	0.1373	0.475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Brugia malayi	cathepsin L-like precursor	0.0413	0.1704	0.3957
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0606	0.2825	1
Brugia malayi	Papain family cysteine protease containing protein	0.0323	0.1181	0.2742
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0606	0.2825	0.6511
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0193	0.0424	0.0984
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Loa Loa (eye worm)	ctsf protein	0.0606	0.2825	0.656
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0157	0.0219	0.0508
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0226	0.0616	0.143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Echinococcus granulosus	cathepsin L	0.0323	0.1181	0.264
Leishmania major	cathepsin L-like protease	0.1839	1	1
Brugia malayi	Cathepsin L-like precursor	0.0606	0.2825	0.656
Entamoeba histolytica	cysteine proteinase, putative	0.0323	0.1181	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1181	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0323	0.1181	0.1128
Trypanosoma cruzi	cysteine peptidase, putative	0.1839	1	1
Schistosoma mansoni	cathepsin s	0.0193	0.0424	0.0984
Schistosoma mansoni	cathepsin F (C01 family)	0.0413	0.1704	0.3957
Trypanosoma cruzi	cysteine proteinase, putative	0.0323	0.1181	0.1128
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0606	0.2825	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0606	0.2825	0.656
Echinococcus multilocularis	cathepsin b	0.086	0.4307	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.013	0.006	0.0139
Trypanosoma cruzi	cruzipain precursor, putative	0.1839	1	1
Onchocerca volvulus		0.0606	0.2825	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0606	0.2825	0.6511
Brugia malayi	Papain family cysteine protease containing protein	0.0323	0.1181	0.2742
Echinococcus granulosus	cathepsin b	0.086	0.4307	1
Brugia malayi	fibroinase precursor	0.013	0.006	0.0139
Loa Loa (eye worm)	hypothetical protein	0.013	0.006	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0606	0.2825	0.656
Onchocerca volvulus		0.0606	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Onchocerca volvulus		0.0606	0.2825	1
Entamoeba histolytica	cysteine protease, putative	0.0323	0.1181	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.013	0.006	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Echinococcus granulosus	cathepsin l1	0.0413	0.1704	0.3872
Trypanosoma cruzi	cysteine peptidase, putative	0.0606	0.2825	0.2782
Trypanosoma cruzi	cysteine proteinase, putative	0.0323	0.1181	0.1128
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.013	0.006	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Entamoeba histolytica	cysteine proteinase, putative	0.0413	0.1704	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1839	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.013	0.006	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0219	0.0508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0606	0.2825	1
Plasmodium vivax	unspecified product	0.0323	0.1181	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= -0.7 g	Activity of the compound against P-388 murine leukemia cells expressed as average weight change at a dose of 16 mg/kg per inj.	ChEMBL.	3079830
Activity (functional)	= -0.5 g	Activity of the compound against P-388 murine leukemia cells expressed as average weight change at a dose of 32 mg/kg per inj.	ChEMBL.	3079830
Activity (functional)	= 1.3 g	Activity of the compound against P-388 murine leukemia cells expressed as average weight change at a dose of 8 mg/kg per inj.	ChEMBL.	3079830
IC50 (functional)	0 uM	inhibitory concentration against estrogen independent human uterus cancer cell line KLE; Not reached IC50 >40 uM	ChEMBL.	15501069
IC50 (functional)	0 uM	inhibitory concentration against estrogen independent human ovarian cancer cell line A2780cp; Not reached IC50 >40 uM	ChEMBL.	15501069
IC50 (functional)	= 7 uM	inhibitory concentration against estrogen independent human ovarian cancer cell line A2780wt	ChEMBL.	15501069
IC50 (functional)	= 20 uM	inhibitory concentration against estrogen independent human uterus cancer cell line HeLa	ChEMBL.	15501069
IC50 (functional)	= 25 uM	Inhibition of estrogen dependent human ovarian cancer OVCAR-3 cell proliferation	ChEMBL.	15501069
IC50 (functional)	= 27.8 uM	Inhibition of estrogen dependent human ovarian cancer SKOV-3 cell proliferation	ChEMBL.	15501069
IC50 (functional)	= 29.8 uM	Inhibition of estrogen dependent human uterus cancer Ishikawa cell proliferation	ChEMBL.	15501069
IC50 (functional)	= 30.9 uM	Inhibition of estrogen dependent human uterus cancer RL-95-2 cell proliferation	ChEMBL.	15501069
IC50 (functional)	= 35.2 uM	inhibitory concentration against estrogen independent human uterus cancer cell line HEC-1-A	ChEMBL.	15501069
MST (functional)	= 100 %	Activity of the compound against P-388 murine leukemia cells expressed as median survival time (MST treated/MST control) at a dose of 8 mg/kg per inj.	ChEMBL.	3079830
MST (functional)	= 120 %	Activity of the compound against P-388 murine leukemia cells expressed as median survival time (MST treated/MST control) at a dose of 16 mg/kg per inj.	ChEMBL.	3079830
MST (functional)	= 130 %	Activity of the compound against P-388 murine leukemia cells expressed as median survival time (MST treated/MST control) at a dose of 32 mg/kg per inj.	ChEMBL.	3079830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 149670

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 48836