TDR Targets

Basic information

Technical information

TDR Targets ID: 500458
Name: 5-fluoro-2-methyl-N-[(3R)-1-[(4-phenoxyphenyl )methyl]pyrrolidin-3-yl]benzenesulfonamide
MW: 440.53 | Formula: C24H25FN2O3S
H donors: 1 H acceptors: 2 LogP: 4.61 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)S(=O)(=O)N[C@@H]1CCN(C1)Cc1ccc(cc1)Oc1ccccc1)C
InChi: 1S/C24H25FN2O3S/c1-18-7-10-20(25)15-24(18)31(28,29)26-21-13-14-27(17-21)16-19-8-11-23(12-9-19)30-22-5-3-2-4-6-22/h2-12,15,21,26H,13-14,16-17H2,1H3/t21-/m1/s1
InChiKey: QMIAWYRBODTBCQ-OAQYLSRUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-fluoro-2-methyl-N-[(3R)-1-[(4-phenoxyphenyl)methyl]-3-pyrrolidinyl]benzenesulfonamide
5-fluoro-2-methyl-N-[(3R)-1-(4-phenoxybenzyl)pyrrolidin-3-yl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	jmjC domain-containing protein	0.0027	0.0608	0.2162
Brugia malayi	photoreceptor-specific nuclear receptor	0.0009	0.0012	0.0022
Onchocerca volvulus		0.0011	0.0068	0.019
Schistosoma mansoni	hypothetical protein	0.0011	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0011	0.0068	0.0068
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0012	0.0012
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0027	0.0616	0.5
Onchocerca volvulus		0.0009	0.0012	0.0019
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0011	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.024
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0027	0.0616	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Echinococcus multilocularis	transmembrane protease serine 3	0.0011	0.0068	0.0068
Onchocerca volvulus		0.0011	0.0068	0.019
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0011	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.0009	0.0006	0.0006
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Loa Loa (eye worm)	steroid hormone receptor	0.0009	0.0012	0.0043
Onchocerca volvulus		0.0009	0.0029	0.0071
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Echinococcus granulosus	FTZ F1 alpha	0.0009	0.0012	0.0012
Leishmania major	cathepsin L-like protease	0.0028	0.0662	1
Onchocerca volvulus		0.0044	0.1187	0.3648
Brugia malayi	PHD-finger family protein	0.0013	0.0145	0.0497
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0027	0.0616	0.0616
Echinococcus granulosus	Mastin	0.0011	0.0068	0.0068
Echinococcus multilocularis	lysine specific demethylase 5A	0.0016	0.0237	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0009	0.0012	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0145	0.0517
Toxoplasma gondii	PAN domain-containing protein	0.0147	0.4654	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Brugia malayi	Bromodomain containing protein	0.0013	0.0145	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Schistosoma mansoni	hypothetical protein	0.0013	0.0145	0.0145
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0009	0.0012	0.0012
Echinococcus granulosus	tissue type plasminogen activator	0.0009	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.0012	0.0022
Onchocerca volvulus		0.0011	0.0068	0.019
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.0012	0.0022
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0009	0.0012	0.0012
Onchocerca volvulus	Alhambra homolog	0.0013	0.0145	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Trypanosoma cruzi	major cysteine proteinase, putative	0.0022	0.0458	0.6897
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0013	0.0156	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0158	0.056
Echinococcus multilocularis	Mastin	0.0011	0.0068	0.0068
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0009	0.0029	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0156	0.0156
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0027	0.0616	1
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Echinococcus multilocularis	enteropeptidase	0.0011	0.0068	0.0068
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.0012	0.0012
Echinococcus multilocularis	peregrin	0.0013	0.0145	0.0145
Echinococcus granulosus	glycoprotein Antigen 5	0.0011	0.0068	0.0068
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0011	0.0068	0.0068
Schistosoma mansoni	aldehyde dehydrogenase	0.0027	0.0616	0.0616
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Plasmodium vivax	SET domain protein, putative	0.0013	0.0156	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0013	0.0156	0.0156
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0662	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0009	0.0012	0.0022
Brugia malayi	jmjC domain containing protein	0.0042	0.1134	0.4019
Toxoplasma gondii	hypothetical protein	0.0009	0.0029	0.0049
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Onchocerca volvulus		0.0009	0.0029	0.0071
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.0029	0.0103
Onchocerca volvulus		0.0009	0.0029	0.0071
Trichomonas vaginalis	set domain proteins, putative	0.0105	0.3243	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0016	0.0237	0.0237
Schistosoma mansoni	hypothetical protein	0.0011	0.0068	0.0068
Brugia malayi	Trypsin family protein	0.0011	0.0068	0.0219
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0009	0.0012	0.0012
Onchocerca volvulus		0.0009	0.0029	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0156	0.0554
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.0029	0.0049
Toxoplasma gondii	hypothetical protein	0.0009	0.0029	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.0012	0.0022
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0013	0.0145	0.0145
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0011	0.0068	0.0068
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0092	0.2814	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0009	0.0012	0.0012
Toxoplasma gondii	microneme protein MIC17B	0.0009	0.0029	0.0049
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.0029	0.0049
Brugia malayi	nuclear hormone receptor	0.0009	0.0012	0.0022
Echinococcus granulosus	enteropeptidase	0.0011	0.0068	0.0068
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0009	0.0012	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0009	0.0012	0.0022
Toxoplasma gondii	microneme protein MIC17A	0.0009	0.0029	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0013	0.0156	0.0156
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0054	0.1544	0.1544
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0013	0.0145	0.0145
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.0029	0.0103
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0009	0.0012	0.0012
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0026	0.0579	0.8742
Echinococcus multilocularis	FTZ F1 alpha	0.0009	0.0012	0.0012
Echinococcus multilocularis	microtubule associated protein 2	0.0305	1	1
Onchocerca volvulus		0.0009	0.0029	0.0071
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Onchocerca volvulus		0.0009	0.0029	0.0071
Echinococcus granulosus	transmembrane protease serine 3	0.0011	0.0068	0.0068
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0013	0.014	0.014
Schistosoma mansoni	jumonji domain containing protein	0.0034	0.0842	0.0842
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0012	0.0012
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0009	0.0012	0.0012
Echinococcus multilocularis	tissue type plasminogen activator	0.0009	0.0006	0.0006
Leishmania major	cathepsin L-like protease	0.0028	0.0662	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0027	0.0616	0.0616
Onchocerca volvulus		0.0009	0.0029	0.0071
Onchocerca volvulus		0.0054	0.1544	0.4751
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Onchocerca volvulus		0.0013	0.0156	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0456	0.1621
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0013	0.0156	0.0156
Echinococcus granulosus	ecdysone induced protein 78C	0.0009	0.0012	0.0012
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0042	0.1134	0.1134
Brugia malayi	Steroid receptor seven-up type 2	0.0009	0.0012	0.0022
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.0012	0.0022
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0056	0.1609	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1544	0.5486
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0009	0.0012	0.0043
Schistosoma mansoni	coup transcription factor	0.0009	0.0012	0.0012
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.0029	0.0103
Brugia malayi	hypothetical protein	0.0011	0.0068	0.0219
Onchocerca volvulus		0.0011	0.0068	0.019
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.0012	0.0022
Toxoplasma gondii	microneme protein, putative	0.0009	0.0029	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Onchocerca volvulus		0.0009	0.0029	0.0071
Echinococcus granulosus	histone lysine methyltransferase setb	0.0013	0.0156	0.0156
Trypanosoma cruzi	cruzipain precursor, putative	0.0028	0.0662	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0009	0.0012	0.0012
Plasmodium falciparum	phd finger protein, putative	0.0013	0.0145	1
Onchocerca volvulus		0.0009	0.0029	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0011	0.0068	0.0068
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0009	0.0012	0.0012
Toxoplasma gondii	microneme protein MIC4	0.0009	0.0029	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0013	0.0156	0.0156
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0009	0.0012	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Echinococcus multilocularis	jumonji domain containing protein	0.0018	0.0316	0.0316
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0009	0.0012	0.0012
Onchocerca volvulus	Bile acid receptor homolog	0.0009	0.0012	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0009	0.0012	0.0043
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0011	0.0068	0.0219
Echinococcus granulosus	jumonji domain containing protein	0.0018	0.0316	0.0316
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0009	0.0012	0.0043
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.0012	0.0022
Schistosoma mansoni	microtubule-associated protein tau	0.0305	1	1
Brugia malayi	Trypsin-like protease protein 5	0.0011	0.0068	0.0219
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0042	0.1134	0.1134
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0011	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0009	0.0012	0.0022
Leishmania major	cathepsin L-like protease	0.0028	0.0662	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0016	0.0237	0.0237
Brugia malayi	Pre-SET motif family protein	0.0092	0.2814	1
Brugia malayi	jmjC domain containing protein	0.0016	0.0237	0.0822
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0011	0.0068	0.0068
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0009	0.0012	0.0012
Toxoplasma gondii	PAN domain-containing protein	0.0147	0.4654	1
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.0012	0.0012
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0009	0.0012	0.0012
Brugia malayi	steroid hormone receptor	0.0009	0.0012	0.0022
Toxoplasma gondii	PHD-finger domain-containing protein	0.0013	0.0145	0.03
Brugia malayi	nuclear receptor NHR-88	0.0009	0.0012	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0012	0.0012
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0012	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0009	0.0012	0.0019
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0011	0.0068	0.0068
Onchocerca volvulus		0.0105	0.3243	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Echinococcus granulosus	peregrin	0.0013	0.0145	0.0145
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0027	0.0616	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Echinococcus granulosus	lysine specific demethylase 5A	0.0016	0.0237	0.0237
Loa Loa (eye worm)	PHD-finger family protein	0.0013	0.0145	0.0517
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.0029	0.0049
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0009	0.0012	0.0012
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0009	0.0012	0.0012
Echinococcus multilocularis	glycoprotein Antigen 5	0.0011	0.0068	0.0068
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0027	0.0616	0.9301
Onchocerca volvulus		0.0009	0.0029	0.0071
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0662	1
Brugia malayi	Pre-SET motif family protein	0.0013	0.0156	0.0534
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0237	0.0842
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Toxoplasma gondii	aldehyde dehydrogenase	0.0027	0.0616	0.1313
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0009	0.0012	0.0022
Onchocerca volvulus		0.0009	0.0029	0.0071
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0027	0.0616	0.0616
Onchocerca volvulus		0.0011	0.0068	0.019
Toxoplasma gondii	PAN domain-containing protein	0.0009	0.0029	0.0049
Brugia malayi	Trypsin family protein	0.0011	0.0068	0.0219
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0009	0.0012	0.0012
Echinococcus granulosus	PHD finger protein rhinoceros	0.0013	0.0145	0.0145
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Loa Loa (eye worm)	TK/ROR protein kinase	0.0009	0.0006	0.0021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Giardia lamblia	PHD finger protein 15	0.0013	0.0145	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0009	0.0012	0.0012
Echinococcus multilocularis	ecdysone induced protein 78C	0.0009	0.0012	0.0012
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.0029	0.0103
Toxoplasma gondii	PHD-finger domain-containing protein	0.0013	0.0145	0.03
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.024
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0009	0.0012	0.0043
Brugia malayi	Trypsin family protein	0.0011	0.0068	0.0219
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0009	0.0012	0.0012
Loa Loa (eye worm)	PAN domain-containing protein	0.0009	0.0029	0.0103
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0009	0.0012	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0009	0.0012	0.0043
Schistosoma mansoni	cercarial elastase (S01 family)	0.0011	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0006	0.0021
Toxoplasma gondii	microneme protein MIC17C	0.0009	0.0029	0.0049
Schistosoma mansoni	retinoic acid receptor RXR	0.0009	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1544	0.5486
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0133	0.0133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0009	0.0012	0.0043
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0009	0.0012	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0043
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Toxoplasma gondii	subtilisin SUB12	0.0009	0.0029	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0662	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0662	1
Brugia malayi	ecdysteroid receptor	0.0009	0.0012	0.0022
Brugia malayi	PAN domain containing protein	0.0009	0.0029	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.024
Loa Loa (eye worm)	trypsin family protein	0.0011	0.0068	0.024
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0009	0.0012	0.0019
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0012	0.0022
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0013	0.0156	0.0156
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0145	0.9306
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0009	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.024
Brugia malayi	Trypsin family protein	0.0054	0.1544	0.5476
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0009	0.0012	0.0012

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 12.3 %	Inhibition of GTPase activity of Esherichia coli FtsZ at 100 uM	ChEMBL.	17923406
MIC (functional)	= 20 uM	Antimicrobial activity against AcrAB efflux pump-deficient Escherichia coli DCR39	ChEMBL.	17923406
MIC (functional)	= 20 uM	Antimicrobial activity against AcrAB efflux pump-deficient Escherichia coli DCR39	ChEMBL.	17923406

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL251159
PubChem: 25045268

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 500458