Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Delta opioid receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ORL1-like opioid receptor | Delta opioid receptor | 372 aa | 300 aa | 24.7 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 316 aa | 26.9 % | |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 344 aa | 22.1 % | |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.5 % |
Echinococcus granulosus | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 27.8 % |
Brugia malayi | GnHR receptor homolog | Delta opioid receptor | 372 aa | 313 aa | 18.5 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 386 aa | 22.8 % | |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Delta opioid receptor | 372 aa | 353 aa | 29.2 % |
Echinococcus multilocularis | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 28.5 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Delta opioid receptor | 372 aa | 366 aa | 22.7 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.2 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 315 aa | 28.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 320 aa | 25.6 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 353 aa | 21.0 % | |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 349 aa | 22.1 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Delta opioid receptor | 372 aa | 317 aa | 23.3 % |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jun protein | 0.0277 | 0.3915 | 0.3983 |
Schistosoma mansoni | hypothetical protein | 0.0225 | 0.3053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.141 | 0.141 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0144 | 0.1696 | 0.1726 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0049 | 0.0129 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0644 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0634 | 0.983 | 1 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0126 | 0.14 | 0.14 |
Onchocerca volvulus | 0.0143 | 0.1687 | 0.5764 | |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1687 | 0.1687 |
Brugia malayi | PAS domain containing protein | 0.0067 | 0.0416 | 0.0416 |
Brugia malayi | bZIP transcription factor family protein | 0.0277 | 0.3915 | 0.3915 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 0.983 | 1 |
Echinococcus multilocularis | jun protein | 0.0277 | 0.3915 | 0.3983 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0277 | 0.3915 | 0.3983 |
Brugia malayi | hypothetical protein | 0.0218 | 0.2927 | 0.2927 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.3789 | 0.3789 |
Echinococcus multilocularis | geminin | 0.0185 | 0.2388 | 0.243 |
Echinococcus granulosus | geminin | 0.0185 | 0.2388 | 0.243 |
Echinococcus granulosus | single minded 2 | 0.0049 | 0.0129 | 0.0131 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.2388 | 0.7824 |
Mycobacterium ulcerans | putative regulatory protein | 0.0049 | 0.0129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.14 | 0.14 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0277 | 0.3915 | 0.3983 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0193 | 0.2514 | 0.8234 |
Schistosoma mansoni | single-minded | 0.0067 | 0.0416 | 0.1362 |
Onchocerca volvulus | 0.0218 | 0.2927 | 1 | |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0144 | 0.1696 | 0.1726 |
Brugia malayi | bHLH-PAS transcription factor | 0.0049 | 0.0129 | 0.0129 |
Onchocerca volvulus | 0.005 | 0.0139 | 0.0473 | |
Schistosoma mansoni | jun-related protein | 0.0225 | 0.3053 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.2388 | 0.7824 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Agonist activity at mu opioid receptor in NMRI mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction | ChEMBL. | 18062664 | |
IC50 (functional) | 0 | Agonist activity at mu opioid receptor in NMRI mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction | ChEMBL. | 18062664 |
Ki (binding) | = 2312 pM | Displacement of [3H]deltorphin 2 from delta opioid receptor in Wistar rat brain after 45 mins | ChEMBL. | 18062664 |
Ki (binding) | = 2312 pM | Displacement of [3H]deltorphin 2 from delta opioid receptor in Wistar rat brain after 45 mins | ChEMBL. | 18062664 |
Ki (binding) | = 8732 pM | Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain after 45 mins | ChEMBL. | 18062664 |
Ki (binding) | = 8732 pM | Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain after 45 mins | ChEMBL. | 18062664 |
Ratio Ki (binding) | = 0.26 | Selectivity for mu opioid receptor over delta opiod receptor in Wistar rat brain | ChEMBL. | 18062664 |
t1/2 (ADMET) | > 24 hr | Stability in rat brain assessed as half life | ChEMBL. | 18062664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.