Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.1428 | 0.4057 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.002 | 0.0142 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.002 | 0.0058 |
Mycobacterium ulcerans | beta-lactamase | 0.011 | 0.1015 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0297 | 0.0843 |
Echinococcus multilocularis | geminin | 0.0343 | 0.352 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0705 | 0.7425 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.1428 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.002 | 0.0142 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1015 | 0.7107 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.011 | 0.1015 | 0.1367 |
Mycobacterium tuberculosis | Conserved protein | 0.011 | 0.1015 | 0.1367 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.002 | 0.0058 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.011 | 0.1015 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.011 | 0.1015 | 0.0985 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0587 | 0.6153 | 0.614 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.002 | 0.0058 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.352 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.011 | 0.1015 | 0.0985 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.011 | 0.1015 | 0.1367 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.0297 | 0.0264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.002 | 0.0142 |
Onchocerca volvulus | 0.011 | 0.1015 | 1 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.1428 | 0.4057 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.002 | 0.0142 |
Loa Loa (eye worm) | beta-lactamase | 0.011 | 0.1015 | 0.7107 |
Mycobacterium leprae | Probable lipase LipE | 0.011 | 0.1015 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.002 | 0.0142 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.002 | 0.0058 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0033 | 0.0094 |
Onchocerca volvulus | 0.011 | 0.1015 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.002 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.002 | 0.0142 |
Mycobacterium ulcerans | lipase LipD | 0.011 | 0.1015 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.011 | 0.1015 | 0.0985 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.002 | 0.0058 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0297 | 0.2923 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.002 | 0.0142 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.011 | 0.1015 | 0.1367 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0297 | 0.2923 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.0297 | 0.0264 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.352 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.002 | 0.0142 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.0945 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.011 | 0.1015 | 0.1367 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.011 | 0.1015 | 0.1367 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.002 | 0.0142 |
Mycobacterium leprae | conserved hypothetical protein | 0.011 | 0.1015 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.011 | 0.1015 | 0.7107 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1015 | 0.7107 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0297 | 0.2923 |
Toxoplasma gondii | ABC1 family protein | 0.011 | 0.1015 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Onchocerca volvulus | 0.011 | 0.1015 | 1 | |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0257 | 1 |
Brugia malayi | beta-lactamase family protein | 0.011 | 0.1015 | 0.7107 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.011 | 0.1015 | 0.7107 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.011 | 0.1015 | 0.1367 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0033 | 0.1292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.002 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.002 | 0.0142 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0033 | 0.0094 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.011 | 0.1015 | 0.2883 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.002 | 0.0142 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.011 | 0.1015 | 0.7107 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.002 | 0.0142 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0257 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0033 | 0.0328 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.002 | 0.0058 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.002 | 0.0058 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.011 | 0.1015 | 0.2883 |
Trypanosoma brucei | hypothetical protein, conserved | 0.011 | 0.1015 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1015 | 0.7107 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.002 | 0.0142 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.002 | 0.0058 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.011 | 0.1015 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0033 | 0.0328 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0033 | 0.0328 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.002 | 0.0142 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0033 | 0.0328 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.002 | 0.0142 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.011 | 0.1015 | 0.2883 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0033 | 0.0328 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.002 | 0.0058 |
Plasmodium vivax | hypothetical protein, conserved | 0.011 | 0.1015 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0033 | 0.0233 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.002 | 0.0142 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.002 | 0.0142 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1015 | 0.7107 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | beta-lactamase | 0.011 | 0.1015 | 0.7107 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.011 | 0.1015 | 0.2883 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0033 | 0.5 |
Echinococcus granulosus | geminin | 0.0343 | 0.352 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.011 | 0.1015 | 0.0985 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.002 | 0.0058 |
Leishmania major | hypothetical protein, conserved | 0.011 | 0.1015 | 1 |
Trichomonas vaginalis | esterase, putative | 0.011 | 0.1015 | 0.0985 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.002 | 0.0058 |
Mycobacterium tuberculosis | Probable hydrolase | 0.011 | 0.1015 | 0.1367 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.002 | 0.0058 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0033 | 0.0094 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.002 | 0.0142 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.002 | 0.0142 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.011 | 0.1015 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.002 | 0.0142 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.002 | 0.0058 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0033 | 0.0094 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.011 | 0.1015 | 0.0985 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.002 | 0.0058 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.011 | 0.1015 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0033 | 0.0328 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.002 | 0.0142 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.002 | 0.0142 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.002 | 0.0058 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.1428 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0033 | 0.0045 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.011 | 0.1015 | 0.1367 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.002 | 0.0058 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.002 | 0.0142 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.1383 | 0.3929 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.002 | 0.0058 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0033 | 0.0233 |
Mycobacterium tuberculosis | Conserved protein | 0.011 | 0.1015 | 0.1367 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.002 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1015 | 0.7107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.002 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.002 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1015 | 0.7107 |
Mycobacterium ulcerans | hypothetical protein | 0.011 | 0.1015 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.002 | 0.0142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 uM | Inhibition of human NEU1 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU2 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU3 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU4 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU1 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU2 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU3 expressed in HEK293 cells | ChEMBL. | 18068975 |
IC50 (binding) | > 1000 uM | Inhibition of human NEU4 expressed in HEK293 cells | ChEMBL. | 18068975 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.