Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0676 | 0.8442 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.141 | 0.6446 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0139 | 0.1314 | 0.6011 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0205 | 0.2187 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1671 | 0.1671 |
Brugia malayi | Bm-MIF-1, identical | 0.0205 | 0.2187 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0179 | 0.0213 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0133 | 0.0133 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.0232 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0484 | 0.2213 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.1314 | 0.1557 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.0232 | 0.0232 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0205 | 0.2187 | 0.6728 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.1314 | 0.1557 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0205 | 0.2187 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.0232 | 0.0274 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.1314 | 0.1314 |
Leishmania major | hypothetical protein, conserved | 0.0285 | 0.325 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0232 | 0.106 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0205 | 0.2187 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0139 | 0.1314 | 0.6011 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0093 | 0.011 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 0.0484 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 0.0573 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.0232 | 0.106 |
Trypanosoma cruzi | hypothetical protein | 0.0285 | 0.325 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0133 | 0.5 |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0285 | 0.325 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0093 | 0.0093 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0115 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0179 | 0.0821 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.141 | 0.141 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0484 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1432 | 0.6549 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.0232 | 0.0232 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0179 | 0.0213 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0093 | 0.011 |
Echinococcus granulosus | geminin | 0.0166 | 0.1671 | 0.1979 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0205 | 0.2187 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0093 | 0.011 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.1314 | 0.1314 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0179 | 0.0213 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0179 | 0.0179 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0093 | 0.0424 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1432 | 0.6549 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0115 | 0.0527 |
Onchocerca volvulus | 0.0148 | 0.1432 | 1 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.0232 | 0.0274 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.1314 | 0.1557 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0179 | 0.0179 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0186 | 0.1934 | 0.2291 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0115 | 0.0527 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.141 | 0.141 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0676 | 0.8442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0115 | 0.0527 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0285 | 0.325 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.1314 | 0.1557 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.141 | 0.6446 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0093 | 0.0424 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.141 | 0.167 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0484 | 0.2213 |
Trypanosoma cruzi | hypothetical protein | 0.0285 | 0.325 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0205 | 0.2187 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0484 | 0.2213 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1671 | 0.1979 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0205 | 0.2187 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0286 | 0.3272 | 0.3876 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0676 | 0.8442 | 0.8442 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0285 | 0.325 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.0232 | 0.0274 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0133 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.141 | 0.6446 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0087 | 0.0627 | 0.2868 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.0484 | 0.2213 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.0232 | 0.106 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0285 | 0.325 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0186 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0093 | 0.0424 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0093 | 0.011 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0205 | 0.2187 | 0.6728 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0484 | 0.0573 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0484 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0093 | 0.0424 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0285 | 0.325 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1671 | 0.1979 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0093 | 0.011 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0179 | 0.0821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 0.2187 | 0.6728 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.1314 | 0.1557 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0205 | 0.2187 | 0.6728 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0093 | 0.0093 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 0.0232 | 0.0274 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0179 | 0.0821 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0087 | 0.0627 | 0.2868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.