TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 227.714 | Formula: C9H10ClN3S+
H donors: 0 H acceptors: 1 LogP: 1.92 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cn1)CN1CCSC1=[NH+]
InChi: 1S/C9H10ClN3S/c10-8-2-1-7(5-12-8)6-13-3-4-14-9(13)11/h1-2,5,11H,3-4,6H2/p+1
InChiKey: WJLMZDWUGGHQEH-UHFFFAOYSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2239	0.2239
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0042	0.0553	0.0481
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0137	0.2609	0.2609
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.1583	0.152
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0637	0.0695
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0137	0.2609	0.2609
Echinococcus multilocularis	glycine receptor subunit beta	0.0137	0.2609	0.3137
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0137	0.2609	0.2553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0637	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Onchocerca volvulus		0.0479	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0133	0.2513	0.2513
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0394	0.8152	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0137	0.2609	0.3137
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.1583	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0683	0.0612
Loa Loa (eye worm)	acetylcholine receptor protein	0.0075	0.1253	0.1253
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0154	0.297	0.5
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0137	0.2609	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0479	1	1
Echinococcus multilocularis	nAChR subunit	0.0137	0.2609	0.3137
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Onchocerca volvulus		0.0137	0.2609	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Brugia malayi	MH2 domain containing protein	0.012	0.2239	0.218
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0137	0.2609	0.3137
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0075	0.1253	0.1253
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0035	0.0405	0.0408
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.462	0.5627
Brugia malayi	Cation transporter family protein	0.0137	0.2609	0.2553
Echinococcus granulosus	nAChR subunit	0.0137	0.2609	0.3137
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0137	0.2609	0.2553
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0075	0.1253	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2239	0.2239
Onchocerca volvulus		0.0063	0.0997	0.0929
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0075	0.0075
Schistosoma mansoni	acetylcholine receptor-related	0.0075	0.1253	0.1187
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0137	0.2609	0.2609
Echinococcus granulosus	dual specificity	0.009	0.1583	0.1867
Entamoeba histolytica	protein kinase, putative	0.009	0.1583	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Brugia malayi	hypothetical protein	0.0075	0.1253	0.1187
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	0.2609	0.2553
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0137	0.2609	0.3137
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.1583	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.1253	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Schistosoma mansoni	metabotropic glutamate receptor	0.0035	0.0405	0.0332
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0137	0.2609	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0683	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Schistosoma mansoni	nAChR subunit	0.0075	0.1253	0.1187
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Echinococcus multilocularis	tumor protein p63	0.0329	0.6756	0.8271
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0168	0.3272	0.5
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0657	0.0586
Echinococcus multilocularis	tar DNA binding protein	0.0133	0.2513	0.3019
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Onchocerca volvulus		0.0047	0.0657	0.0586
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0137	0.2609	0.2609
Echinococcus granulosus	glycine receptor subunit beta	0.0137	0.2609	0.3137
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0075	0.1253	0.1187
Loa Loa (eye worm)	TAR-binding protein	0.0133	0.2513	0.2513
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2513	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0137	0.2609	0.3137
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0137	0.2609	0.2553
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	0.2609	0.2553
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0075	0.1253	0.1458
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	0.2609	0.2553
Schistosoma mansoni	neurotransmitter gated ion channel	0.0075	0.1253	0.1187
Loa Loa (eye worm)	RNA binding protein	0.0133	0.2513	0.2513
Brugia malayi	hypothetical protein	0.0075	0.1253	0.1187
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0657	0.0586
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	0.2609	0.2553
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0137	0.2609	0.3137
Onchocerca volvulus		0.0063	0.0997	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0137	0.2609	0.3137
Entamoeba histolytica	hypothetical protein	0.009	0.1583	1
Onchocerca volvulus	Putative nachr subunit	0.0394	0.8152	0.8138
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0637	0.0695
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0063	0.0997	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0394	0.8152	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0048	0.0678	0.0607
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Echinococcus granulosus	tumor protein p63	0.0329	0.6756	0.8271
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0052	0.0763	0.0852
Schistosoma mansoni	nAChR subunit	0.0075	0.1253	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0479	1	1
Brugia malayi	hypothetical protein	0.023	0.462	0.458
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0038	0.0467	0.0395
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0137	0.2609	0.2609
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0035	0.0405	0.0408
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0168	0.3272	0.3272
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0137	0.2609	0.3137
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0637	0.0566
Loa Loa (eye worm)	hypothetical protein	0.023	0.462	0.462
Brugia malayi	RNA binding protein	0.0133	0.2513	0.2457
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.009	0.1583	0.5
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0063	0.0997	0.0929
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2513	0.2457
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0137	0.2609	0.3137
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0394	0.8152	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0137	0.2609	0.2553
Schistosoma mansoni	metabotropic glutamate receptor	0.0021	0.0086	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	0.2609	0.2553
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0075	0.1253	0.1458
Schistosoma mansoni	neurotransmitter gated ion channel	0.0063	0.0997	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0763	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0063	0.0997	0.0929
Onchocerca volvulus		0.0048	0.0683	0.0612
Onchocerca volvulus		0.0137	0.2609	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1573	0.1573
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0479	1	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0075	0.1253	0.1187
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0063	0.0997	0.0929
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	0.2609	0.2553
Loa Loa (eye worm)	glutamate receptor	0.0042	0.0553	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0137	0.2609	0.3137
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.1253	0.1187
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0137	0.2609	0.3137
Echinococcus granulosus	glycine receptor subunit beta	0.0137	0.2609	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.1253	0.1187
Echinococcus granulosus	tar DNA binding protein	0.0133	0.2513	0.3019
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0075	0.1253	0.1458
Brugia malayi	Cation transporter family protein	0.0137	0.2609	0.2553
Brugia malayi	follicle stimulating hormone receptor	0.0241	0.4854	0.4815
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	0.2609	0.2553
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0075	0.0075
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	0.2609	0.2553
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0168	0.3272	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0075	0.0075
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0052	0.0763	0.0852
Brugia malayi	Protein kinase domain containing protein	0.009	0.1583	0.152
Onchocerca volvulus		0.0075	0.1253	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.462	0.5627
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0075	0.1253	0.1253
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0137	0.2609	0.2553
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0997	0.0929
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0637	0.0695
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0137	0.2609	0.3137
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0075	0.0075
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.009	0.1583	0.1583
Loa Loa (eye worm)	GABA receptor subunit	0.0063	0.0997	0.0997
Echinococcus multilocularis	dual specificity	0.009	0.1583	0.1867
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0394	0.8152	0.8138
Brugia malayi	RNA recognition motif domain containing protein	0.0133	0.2513	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1573	0.1573
Onchocerca volvulus		0.0479	1	1
Brugia malayi	hypothetical protein	0.0075	0.1253	0.1187
Schistosoma mansoni	d-amino acid oxidase	0.0168	0.3272	0.3221
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0997	0.0997
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0075	0.0075
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0137	0.2609	0.3137
Brugia malayi	hypothetical protein	0.0075	0.1253	0.1187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0637	0.0566
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0241	0.4854	0.4854
Onchocerca volvulus		0.0479	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0637	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Onchocerca volvulus		0.0075	0.1253	0.1187
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.009	0.1583	0.5
Entamoeba histolytica	protein kinase, putative	0.009	0.1583	1
Schistosoma mansoni	nAChR subunit	0.0137	0.2609	0.2553
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0637	0.0637
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	0.2609	0.2553
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Loa Loa (eye worm)	LGC-31 protein	0.0137	0.2609	0.2609
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0394	0.8152	1
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0075	0.1253	0.1458
Schistosoma mansoni	hypothetical protein	0.0047	0.0657	0.0586
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0637	0.0695
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0394	0.8152	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0479	1	1
Onchocerca volvulus		0.0075	0.1253	0.1187
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0075	0.0075
Onchocerca volvulus		0.0137	0.2609	0.2553
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0137	0.2609	0.3137
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0394	0.8152	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0075	0.1253	0.1187
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2513	0.2457
Echinococcus granulosus	nAChR subunit	0.0063	0.0997	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Brugia malayi	hypothetical protein	0.0075	0.1253	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Brugia malayi	metabotropic glutamate receptor type 2	0.0021	0.0086	0.0011
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0075	0.1253	0.1187
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1253	0.1253
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	0.2609	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2513	0.2457
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2513	0.2457
Loa Loa (eye worm)	ACC-1 protein	0.0137	0.2609	0.2609
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0137	0.2609	0.2553
Echinococcus multilocularis	glycine receptor subunit beta	0.0137	0.2609	0.3137
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0137	0.2609	0.2553
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.1583	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0997	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0405	0.8389	0.8389
Loa Loa (eye worm)	hypothetical protein	0.002	0.0075	0.0075
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0075	0.1253	0.1187
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	0.2609	0.2553
Echinococcus multilocularis	nAChR subunit	0.0063	0.0997	0.1142
Brugia malayi	TAR-binding protein	0.0133	0.2513	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0137	0.2609	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0394	0.8152	0.8152
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0394	0.8152	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2609	0.2609
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0075	0.0075
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0137	0.2609	0.2553
Loa Loa (eye worm)	ACC-1 protein	0.0137	0.2609	0.2609

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 8.5 nM	Displacement of [3H]EPI from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay	ChEMBL.	17485662
Ki (binding)	= 10 nM	Displacement of [3H]ACE from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay	ChEMBL.	17485662

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 528648

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 511581