Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 alpha | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1001 | 0.1001 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.706 | 0.5 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0102 | 0.6135 | 0.5705 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0024 | 0.1001 | 0.1001 |
Echinococcus granulosus | protein kinase shaggy | 0.0116 | 0.706 | 0.6898 |
Onchocerca volvulus | 0.0116 | 0.706 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2573 | 0.2573 |
Echinococcus multilocularis | CREB binding protein | 0.007 | 0.4025 | 0.3696 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0161 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0161 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0116 | 0.706 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0024 | 0.1001 | 0.0505 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0102 | 0.6135 | 0.5705 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.706 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0.706 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0.706 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.0102 | 0.6135 | 0.5922 |
Brugia malayi | intracellular kinase | 0.0116 | 0.706 | 0.6733 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0.706 | 0.706 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0116 | 0.706 | 1 |
Loa Loa (eye worm) | CBP-B | 0.0071 | 0.4084 | 0.4084 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0116 | 0.706 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0116 | 0.706 | 0.6898 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0024 | 0.1001 | 0.1001 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0.706 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0161 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0024 | 0.1001 | 0.0505 |
Echinococcus multilocularis | protein kinase shaggy | 0.0116 | 0.706 | 0.6898 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0.706 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0161 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0.706 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0116 | 0.706 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0116 | 0.706 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0116 | 0.706 | 0.5 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0116 | 0.706 | 0.6733 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Brugia malayi | TAZ zinc finger family protein | 0.0102 | 0.6135 | 0.5705 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0024 | 0.1001 | 0.0505 |
Brugia malayi | Choline O-acetyltransferase | 0.0161 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0024 | 0.1001 | 0.0505 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0116 | 0.706 | 0.6898 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0.706 | 0.706 |
Echinococcus granulosus | CREB binding protein | 0.0063 | 0.3562 | 0.3207 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 36 nM | Inhibitory activity to human glycogen synthase kinase-3 alpha (GSK-3alpha) was determined | ChEMBL. | 12941332 |
IC50 (binding) | = 36 nM | Inhibition of recombinant GSK3beta (unknown origin) | ChEMBL. | 18324764 |
IC50 (binding) | = 36 nM | Inhibitory activity to human glycogen synthase kinase-3 alpha (GSK-3alpha) was determined | ChEMBL. | 12941332 |
IC50 (binding) | = 36 nM | Inhibition of recombinant GSK3beta (unknown origin) | ChEMBL. | 18324764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.