Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0026 | 0.0549 | 0.0549 |
Onchocerca volvulus | 0.0196 | 1 | 0.5 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0549 | 0.2247 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0549 | 0.2247 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.006 | 0.2444 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0549 | 0.0549 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.006 | 0.2444 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0549 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1988 | 0.1988 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0196 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0549 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0549 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1988 | 0.1988 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0549 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1067 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1988 | 0.1988 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1067 | 0.1067 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0196 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0028 | 0.0028 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0196 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0549 | 0.2247 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1988 | 0.1988 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1067 | 0.1067 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0196 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0196 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0549 | 0.2247 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.006 | 0.2444 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0196 | 1 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.006 | 0.2444 | 1 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0135 | 0.6633 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0196 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0196 | 1 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0196 | 1 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0196 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at human adenosine A2A receptor expressed in CHO cells by cAMP assay | ChEMBL. | 18226909 | |
Activity (functional) | Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells by cAMP assay | ChEMBL. | 18226909 | |
Activity (functional) | 0 | Antagonist activity at human adenosine A2A receptor expressed in CHO cells by cAMP assay | ChEMBL. | 18226909 |
Activity (functional) | 0 | Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells by cAMP assay | ChEMBL. | 18226909 |
Kd (functional) | = 6.4 | Antagonist activity at adenosine A2A receptor in Sprague-Dawley rat aorta smooth muscle | ChEMBL. | 18226909 |
Ki (binding) | = -7.61 | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells | ChEMBL. | 18226909 |
Ki (binding) | = -6.58 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 18226909 | |
Log Ki (binding) | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 18226909 | |
Log Ki (binding) | 0 | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | 0 | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | = 6.58 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 18226909 |
Log Ki (binding) | = 7.61 | Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells | ChEMBL. | 18226909 |
pA2 (functional) | = 6.4 | Antagonist activity at adenosine A2A receptor in Sprague-Dawley rat aorta smooth muscle | ChEMBL. | 18226909 |
pA2 (functional) | = 7.5 | Antagonist activity at adenosine A2B receptor in guinea pig thoracic aorta smooth muscle | ChEMBL. | 18226909 |
Ratio (binding) | = 10.7 | Selectivity index, ratio for human adenosine A2A receptor to human adenosine A2B receptor | ChEMBL. | 18226909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.