Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0282 | 0.2722 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0492 | 0.509 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0335 | 0.332 | 0.6258 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0492 | 0.509 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0298 | 0.2906 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0282 | 0.2722 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Onchocerca volvulus | 0.0055 | 0.0175 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0271 | 0.26 | 0.26 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0492 | 0.509 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0159 | 0.1343 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0282 | 0.2722 | 0.4994 |
Mycobacterium ulcerans | acetolactate synthase | 0.0282 | 0.2722 | 0.4994 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0159 | 0.1343 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0492 | 0.509 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0175 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.26 | 0.8947 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0175 | 0.0408 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0335 | 0.332 | 0.6111 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0175 | 0.0408 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0492 | 0.509 | 1 |
Brugia malayi | hypothetical protein | 0.0271 | 0.26 | 0.5108 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0282 | 0.2722 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.021 | 0.1922 | 0.3304 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0159 | 0.1343 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0271 | 0.26 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0335 | 0.332 | 0.6258 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0159 | 0.1343 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.042 | 0.4285 | 1 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0087 | 0.0537 | 0.0378 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0282 | 0.2727 | 0.9385 |
Schistosoma mansoni | acetolactate synthase | 0.042 | 0.4285 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0685 | 0.7263 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0685 | 0.7263 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0492 | 0.509 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0685 | 0.7263 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0492 | 0.509 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0492 | 0.509 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.1343 | 0.208 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0282 | 0.2722 | 0.4994 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Increase in IFNgamma stimulated nitric oxide production in C57BL/6 mouse peritoneal macrophages at 100 uM after 24 hrs | ChEMBL. | 17964173 |
Activity (ADMET) | 0 | Cytotoxicity against mouse L929 cells | ChEMBL. | 17964173 |
Activity (ADMET) | 0 | Cytotoxicity against mouse L1210 cells | ChEMBL. | 17964173 |
Activity (ADMET) | 0 | Cytotoxicity against human HeLaS3 cells | ChEMBL. | 17964173 |
Activity (functional) | 0 | Antiviral activity against MSV | ChEMBL. | 17964173 |
Activity (functional) | 0 | Antiviral activity against HIV1 | ChEMBL. | 17964173 |
Activity (functional) | 0 | Antiviral activity against HIV2 | ChEMBL. | 17964173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.