Detailed information for compound 518010

Basic information

Technical information
  • TDR Targets ID: 518010
  • Name: 1-(1,3-oxazol-2-yl)-4-[1-[(3-propan-2-ylpheny l)methyl]piperidin-4-yl]butan-1-one
  • MW: 354.486 | Formula: C22H30N2O2
  • H donors: 0 H acceptors: 2 LogP: 4.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cccc(c1)CN1CCC(CC1)CCCC(=O)c1ncco1)C
  • InChi: 1S/C22H30N2O2/c1-17(2)20-7-3-6-19(15-20)16-24-12-9-18(10-13-24)5-4-8-21(25)22-23-11-14-26-22/h3,6-7,11,14-15,17-18H,4-5,8-10,12-13,16H2,1-2H3
  • InChiKey: NFPIJCNXUVBLSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[1-[(3-isopropylphenyl)methyl]-4-piperidyl]-1-oxazol-2-yl-butan-1-one
  • 4-[1-[(3-isopropylphenyl)methyl]-4-piperidinyl]-1-(2-oxazolyl)-1-butanone
  • 4-[1-(3-isopropylbenzyl)-4-piperidyl]-1-oxazol-2-yl-butan-1-one
  • 4-[1-[(3-isopropylphenyl)methyl]-4-piperidinyl]-1-(2-oxazolyl)butan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid amide hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major hypothetical protein, conserved fatty acid amide hydrolase 579 aa 471 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2253 0.8115
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0015 0.0217 0.6812
Trypanosoma cruzi amidase, putative 0.0015 0.0217 0.3094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Schistosoma mansoni amidase 0.0123 0.2777 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0597 0.0597
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.3724 0.3724
Plasmodium vivax hexose transporter 0.0101 0.2253 0.2253
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0201 0.5052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0015 0.0217 0.3094
Onchocerca volvulus 0.0014 0.0201 0.5
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0201 0.0894
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0015 0.0217 0.6812
Loa Loa (eye worm) hypothetical protein 0.0023 0.0399 0.1436
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0399 0.1436
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0201 0.6328
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0015 0.0217 0.0781
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Leishmania major glucose transporter, lmgt2 0.0031 0.0606 0.8651
Plasmodium falciparum protein kinase 7 0.0285 0.6612 0.6612
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0701 1
Onchocerca volvulus 0.0014 0.0201 0.5
Loa Loa (eye worm) amidase 0.0015 0.0217 0.0781
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Onchocerca volvulus 0.0014 0.0201 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Trypanosoma brucei sugar transporter, putative 0.0014 0.0201 0.2874
Mycobacterium ulcerans amidase 0.0015 0.0217 0.5439
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.3724 0.5632
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0201 0.5052
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0701 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0597 0.8517
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0597 0.0903
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0201 0.0725
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0399 0.0603
Mycobacterium ulcerans amidase 0.0015 0.0217 0.5439
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus multilocularis General substrate transporter 0.0087 0.1918 0.6906
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Brugia malayi putative amidase 0.0015 0.0217 0.0781
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0015 0.0217 0.3725
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0701 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0701 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5689
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0399 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0399 0.0399
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0582 0.2096
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0399 0.1436
Brugia malayi major facilitator superfamily protein 0.0014 0.0201 0.0725
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0725
Giardia lamblia Sugar-proton symporter 0.0014 0.0201 0.346
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.2777 1
Trypanosoma brucei glucose transporter 1E 0.0031 0.0606 0.8651
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2253 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0201 0.6328
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0015 0.0217 0.0781
Onchocerca volvulus Putative transporter 0.0014 0.0201 0.5
Plasmodium falciparum hexose transporter 0.0101 0.2253 0.2253
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0201 0.0201
Brugia malayi amidase 0.0123 0.2777 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Onchocerca volvulus 0.0014 0.0201 0.5
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0201 0.9289
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0597 0.2149
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0119 0.2978
Trypanosoma brucei glucose transporter 2A 0.0031 0.0606 0.8651
Brugia malayi Amidase family protein 0.0015 0.0217 0.0781
Leishmania major hypothetical protein, conserved 0.0015 0.0217 0.3094
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0725
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.3724 0.3724
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0725
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0217 0.5439
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0015 0.0217 0.3725
Onchocerca volvulus 0.0014 0.0201 0.5
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0725
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0399 1
Loa Loa (eye worm) sugar transporter 0.0101 0.2253 0.8115
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0606 0.8651
Onchocerca volvulus 0.0014 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Onchocerca volvulus 0.0014 0.0201 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0015 0.0217 0.6812
Trypanosoma cruzi hexose transporter 0.0031 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0606 0.8651
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0597 0.0597
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0582 0.2096
Onchocerca volvulus 0.0014 0.0201 0.5
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0217 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0606 0.269
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5689
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0582 0.2096
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0597 0.2149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0318 0.5469
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.003 0.0582 0.2096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) amidase 0.0015 0.0217 0.0781
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0606 0.269
Onchocerca volvulus 0.0014 0.0201 0.5
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0606 0.8651
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0015 0.0217 0.6812
Brugia malayi hypothetical protein 0.0014 0.0201 0.0725
Brugia malayi Sugar transporter family protein 0.0014 0.0201 0.0725
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0701 0.106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Loa Loa (eye worm) hypothetical protein 0.0123 0.2777 1
Schistosoma mansoni glucose transport protein 0.0101 0.2253 0.8115
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0701 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0606 0.269
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0119 0.2978
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0725
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0201 0.0725
Schistosoma mansoni protein kinase 0.0031 0.0597 0.2149
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0597 0.0597
Schistosoma mansoni protein kinase 0.0031 0.0597 0.2149
Toxoplasma gondii protein kinase, putative 0.0285 0.6612 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.2777 1
Plasmodium vivax sugar transporter, putative 0.0014 0.0201 0.0201
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0582 0.2096
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.2777 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0201 0.2874
Echinococcus granulosus General substrate transporter 0.0087 0.1918 0.6906
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0333 0.1477
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0318 1
Schistosoma mansoni glucose transport protein 0.0101 0.2253 0.8115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.2149
Echinococcus granulosus solute carrier family 22 0.0014 0.0201 0.0725
Onchocerca volvulus 0.0014 0.0201 0.5
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0399 0.5689
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0606 0.269
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0015 0.0217 0.0781
Toxoplasma gondii sugar transporter ST3 0.0014 0.0201 0.0305
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.2777 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0597 0.2648
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0217 0.5439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0025 0.0448 0.1612
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0201 0.0725
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0217 0.0217
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0015 0.0217 0.0217
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0597 0.0903
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0597 0.2149
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.2777 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0101 0.2253 0.8115
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0119 0.5474
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0552 0.1986
Schistosoma mansoni protein kinase 0.0031 0.0597 0.2149
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0015 0.0217 0.6812
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0399 0.6849
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0582 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Onchocerca volvulus 0.0014 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) sugar transporter 0.0014 0.0201 0.0725
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Onchocerca volvulus 0.0014 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0017 0.027 0.386
Brugia malayi Sugar transporter family protein 0.0101 0.2253 0.8115
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0597 0.2149
Brugia malayi Cam kinase protein 1 0.0031 0.0597 0.2149
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0606 0.8651
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0597 0.0903
Loa Loa (eye worm) hypothetical protein 0.003 0.0582 0.2096
Leishmania major glucose transporter, lmgt1 0.0031 0.0606 0.8651
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2253 0.8115
Entamoeba histolytica protein kinase, putative 0.0031 0.0597 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Trypanosoma brucei glucose transporter, putative 0.0031 0.0606 0.8651
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0582 0.2096
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0399 0.1769
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0399 0.6849
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0701 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0201 0.0725
Brugia malayi Sugar transporter family protein 0.0014 0.0201 0.0725
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0201 0.2874
Echinococcus multilocularis solute carrier family 22 0.0014 0.0201 0.0725
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0701 0.0701
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0399 0.1436
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0201 0.0725
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0552 0.1986
Onchocerca volvulus 0.0014 0.0201 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Entamoeba histolytica protein kinase, putative 0.0031 0.0597 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0201 0.5052
Toxoplasma gondii sugar transporter ST2 0.0014 0.0201 0.0305
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0606 0.269
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0399 0.1436
Mycobacterium ulcerans amidase 0.0015 0.0217 0.5439
Schistosoma mansoni sugar transporter 0.0014 0.0201 0.0725
Trypanosoma cruzi amidase, putative 0.0015 0.0217 0.3094
Echinococcus granulosus fatty acid amide hydrolase 1 0.0015 0.0217 0.0781
Schistosoma mansoni glucose transport protein 0.0101 0.2253 0.8115
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0597 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.016 0.0575
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0582 0.9752
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0597 0.0597
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0201 0.0725
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0015 0.0217 0.0781
Giardia lamblia Hexose transporter 0.0014 0.0201 0.346
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Onchocerca volvulus 0.0014 0.0201 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0217 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0399 0.1436
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0201 0.2874
Schistosoma mansoni glucose transporter 0.0014 0.0201 0.0725
Brugia malayi hypothetical protein 0.0014 0.0201 0.0725
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0597 0.0597
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0399 0.0399
Entamoeba histolytica hypothetical protein 0.0023 0.0399 0.6679
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0201 0.0894
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0399 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0582 0.2096
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0201 0.0725
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0582 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0318 1
Onchocerca volvulus 0.0014 0.0201 0.5
Leishmania major glucose transporter, lmgt3 0.0031 0.0606 0.8651
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0582 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0201 0.0894
Leishmania major protein kinase, putative 0.0031 0.0597 0.8517
Mycobacterium ulcerans sugar transporter 0.0014 0.0201 0.5052
Mycobacterium ulcerans peptide amidase, GatA 0.0015 0.0217 0.5439
Mycobacterium ulcerans amidase 0.0015 0.0217 0.5439
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0201 0.0725
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2253 0.3408
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0606 0.8651
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0597 0.2149
Brugia malayi Amidase family protein 0.0015 0.0217 0.0781
Leishmania major hypothetical protein, conserved 0.0014 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0201 0.0894
Mycobacterium ulcerans amidase 0.0015 0.0217 0.5439
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0606 0.269
Brugia malayi hypothetical protein 0.0014 0.0201 0.0725
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0217 0.0781
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0597 0.2149
Toxoplasma gondii sugar transporter ST1 0.0014 0.0201 0.0305
Onchocerca volvulus 0.0014 0.0201 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0201 0.0725
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0201 0.0305
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0606 0.8651

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 nM Inhibition of human FAAH ChEMBL. 18289847
IC50 (binding) = 1 nM Inhibition of human FAAH ChEMBL. 18289847
IC50 (binding) = 3.6 nM Inhibition of FAAH ChEMBL. 18983142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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