TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 403.499 | Formula: C19H25N5O3S
H donors: 2 H acceptors: 5 LogP: 0.28 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC(CN(S(=O)(=O)c1cccc2c1ccnc2)C)CNCCCn1cncc1
InChi: 1S/C19H25N5O3S/c1-23(14-17(25)13-20-7-3-10-24-11-9-22-15-24)28(26,27)19-5-2-4-16-12-21-8-6-18(16)19/h2,4-6,8-9,11-12,15,17,20,25H,3,7,10,13-14H2,1H3
InChiKey: UHLFTSOJVILXNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sugar transporter	0.003	0.0534	0.1156
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0552	0.1194
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0597	0.1292
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Trichomonas vaginalis	glucose transporter, putative	0.003	0.0534	0.1156
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Trypanosoma cruzi	hexose transporter	0.0066	0.134	1
Echinococcus multilocularis	solute carrier family 22	0.003	0.0534	0.1156
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Brugia malayi	hypothetical protein	0.003	0.0534	0.1156
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0597	0.0597
Echinococcus granulosus	Sugar transporter ERD6 protein	0.003	0.0534	0.1156
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.003	0.0534	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0597	0.0597
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0399	0.0399
Onchocerca volvulus		0.003	0.0534	0.5
Brugia malayi	hypothetical protein	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0701	0.5228
Onchocerca volvulus		0.003	0.0534	0.5
Schistosoma mansoni	sugar transporter	0.003	0.0534	0.1156
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0534	0.1156
Mycobacterium ulcerans	sugar transporter	0.003	0.0534	1
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.134	0.2901
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.003	0.0534	0.1156
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0597	0.0903
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Plasmodium vivax	sugar transporter, putative	0.003	0.0534	0.0534
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0174	0.3724	0.3724
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0701	0.0701
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.134	0.2901
Giardia lamblia	Hexose transporter	0.003	0.0534	0.9179
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Onchocerca volvulus		0.003	0.0534	0.5
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0456	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0534	0.1156
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.2974
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0582	0.126
Trypanosoma brucei	sugar transporter, putative	0.003	0.0534	0.3986
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0399	0.0863
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.5469
Giardia lamblia	Sugar-proton symporter	0.003	0.0534	0.9179
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0399	0.6849
Loa Loa (eye worm)	sugar transporter	0.0214	0.462	1
Onchocerca volvulus		0.003	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Schistosoma mansoni	glucose transport protein	0.0214	0.462	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0534	0.1156
Toxoplasma gondii	sugar transporter ST1	0.003	0.0534	0.0808
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0534	0.1156
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0534	0.3986
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0597	0.1292
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.2974
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0701	0.5228
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0597	0.0597
Schistosoma mansoni	hypothetical protein	0.0214	0.462	1
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0597	0.0903
Leishmania major	glucose transporter, lmgt3	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Echinococcus multilocularis	solute carrier family 22	0.003	0.0534	0.1156
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0399	0.0603
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0597	0.1292
Onchocerca volvulus		0.003	0.0534	0.5
Trichomonas vaginalis	myo-inositol transporter, putative	0.003	0.0534	0.1156
Schistosoma mansoni	protein kinase	0.0033	0.0597	0.1292
Plasmodium falciparum	hexose transporter	0.0214	0.462	0.462
Onchocerca volvulus		0.003	0.0534	0.5
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0701	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0597	0.0597
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Mycobacterium ulcerans	integral membrane transport protein	0.003	0.0534	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Onchocerca volvulus		0.003	0.0534	0.5
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Brugia malayi	hypothetical protein	0.003	0.0534	0.1156
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Echinococcus multilocularis	solute carrier family 22	0.003	0.0534	0.1156
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.003	0.0534	0.3986
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Echinococcus multilocularis	synaptic vesicle 2 protein	0.003	0.0534	0.1156
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0174	0.3724	0.5632
Schistosoma mansoni	glucose transport protein	0.0214	0.462	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.003	0.0534	0.1156
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Trypanosoma brucei	glucose transporter 1E	0.0066	0.134	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0597	0.0597
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0597	0.0597
Echinococcus granulosus	solute carrier family 22	0.003	0.0534	0.1156
Plasmodium falciparum	protein kinase 7	0.0303	0.6612	0.6612
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.134	0.2901
Onchocerca volvulus		0.003	0.0534	0.5
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.0863
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.003	0.0534	0.1156
Trypanosoma cruzi	sugar transporter, putative	0.003	0.0534	0.3986
Schistosoma mansoni	protein kinase	0.0033	0.0597	0.1292
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0534	0.1156
Onchocerca volvulus		0.003	0.0534	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Schistosoma mansoni	sugar transporter	0.003	0.0534	0.1156
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0582	0.126
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0399	0.0863
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0582	0.126
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Entamoeba histolytica	hypothetical protein	0.0024	0.0399	0.6679
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0597	0.1292
Onchocerca volvulus		0.003	0.0534	0.5
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0399	0.7462
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.003	0.0534	1
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Toxoplasma gondii	sugar transporter ST3	0.003	0.0534	0.0808
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0582	0.126
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2222
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0582	1
Echinococcus granulosus	solute carrier family 22	0.003	0.0534	0.1156
Onchocerca volvulus		0.003	0.0534	0.5
Onchocerca volvulus		0.003	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Toxoplasma gondii	transporter, major facilitator family protein	0.003	0.0534	0.0808
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0597	0.0597
Brugia malayi	Sugar transporter family protein	0.0214	0.462	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0597	0.1292
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0399	0.6849
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.003	0.0534	1
Toxoplasma gondii	sugar transporter ST2	0.003	0.0534	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0448	0.0969
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0701	0.5228
Brugia malayi	Sugar transporter family protein	0.003	0.0534	0.1156
Entamoeba histolytica	protein kinase, putative	0.0033	0.0597	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.003	0.0534	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0701	0.5228
Schistosoma mansoni	glucose transporter	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0399	0.0863
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trypanosoma cruzi	glucose transporter, putative	0.003	0.0534	0.3986
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0399	0.7462
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.134	0.2901
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0399	0.0863
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Loa Loa (eye worm)	sugar transporter	0.003	0.0534	0.1156
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0318	0.5958
Onchocerca volvulus		0.003	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0534	0.1156
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0597	0.1292
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.134	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0174	0.3724	0.3724
Leishmania major	myo-inositol/proton symporter (MIT)	0.003	0.0534	0.3986
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Leishmania major	glucose transporter, lmgt2	0.0066	0.134	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0214	0.462	0.6988
Echinococcus granulosus	General substrate transporter	0.0184	0.3952	0.8553
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Leishmania major	glucose transporter, lmgt1	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0552	0.1194
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Leishmania major	hypothetical protein, conserved	0.003	0.0534	0.3986
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.2974
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0534	0.1156
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0399	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Trypanosoma brucei	glucose transporter 2A	0.0066	0.134	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0582	0.126
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0582	0.126
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0582	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0582	0.126
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0582	0.126
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0597	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0672	0.5012
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.134	0.2901
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Onchocerca volvulus		0.003	0.0534	0.5
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.003	0.0534	0.0534
Echinococcus granulosus	solute carrier family 22	0.003	0.0534	0.1156
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0597	0.4453
Echinococcus multilocularis	General substrate transporter	0.0184	0.3952	0.8553
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1292
Brugia malayi	Cam kinase protein 1	0.0033	0.0597	0.1292
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0399	0.0863
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0597	0.0903
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0582	0.126
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0346
Echinococcus granulosus	solute carrier family 22	0.003	0.0534	0.1156
Onchocerca volvulus		0.003	0.0534	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.134	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.5958
Entamoeba histolytica	protein kinase, putative	0.0033	0.0597	1
Trypanosoma brucei	glucose transporter, putative	0.0066	0.134	1
Schistosoma mansoni	glucose transport protein	0.0214	0.462	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.462	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0333	0.0721
Brugia malayi	Sugar transporter family protein	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.134	0.2901
Brugia malayi	major facilitator superfamily protein	0.003	0.0534	0.1156
Schistosoma mansoni	sugar transporter	0.003	0.0534	0.1156
Toxoplasma gondii	protein kinase, putative	0.0303	0.6612	1
Plasmodium vivax	hexose transporter	0.0214	0.462	0.462
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.134	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0701	0.106
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.134	0.2901
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0597	0.1292
Leishmania major	protein kinase, putative	0.0033	0.0597	0.4453
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0214	0.462	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0597	0.0597
Onchocerca volvulus		0.003	0.0534	0.5
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Echinococcus multilocularis	solute carrier family 22	0.003	0.0534	0.1156
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.003	0.0534	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transport protein, putative	0.003	0.0534	0.1156
Trichomonas vaginalis	conserved hypothetical protein	0.0214	0.462	1
Onchocerca volvulus	Putative transporter	0.003	0.0534	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0534	0.1156
Schistosoma mansoni	protein kinase	0.0033	0.0597	0.1292
Brugia malayi	major facilitator superfamily protein	0.003	0.0534	0.1156
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0701	0.5228
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0582	0.9752
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0399	0.0863
Loa Loa (eye worm)	hypothetical protein	0.003	0.0534	0.1156

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 50 ug ml-1	Antimalarial activity against Plasmodium falciparum NF54 after 36 to 40 hrs	ChEMBL.	18039570
MIC (functional)	= 50 ug ml-1	Antimalarial activity against Plasmodium falciparum NF54 after 36 to 40 hrs	ChEMBL.	18039570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 521230