Detailed information for compound 521850

Basic information

Technical information
  • TDR Targets ID: 521850
  • Name: 5-[4-(imidazol-1-ylmethyl)phenyl]pyrimidine
  • MW: 236.272 | Formula: C14H12N4
  • H donors: 0 H acceptors: 3 LogP: 1.51 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ncc(cn1)c1ccc(cc1)Cn1ccnc1
  • InChi: 1S/C14H12N4/c1-3-13(14-7-16-10-17-8-14)4-2-12(1)9-18-6-5-15-11-18/h1-8,10-11H,9H2
  • InChiKey: WCJRWPHNXJZMKF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[4-(1-imidazolylmethyl)phenyl]pyrimidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter, lmgt1 0.0031 0.0413 0.8107
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0109 0.0109
Echinococcus granulosus twitchin 0.0014 0.0103 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.0395 0.0393
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0413 0.8107
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0107
Echinococcus granulosus tyrosine kinase 0.0037 0.0513 0.0511
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0046 0.5
Schistosoma mansoni tyrosine kinase 0.0358 0.6202 0.6202
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0513 0.0511
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.0577 0.0576
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0413 0.8107
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.0577 0.0576
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0109 0.0107
Loa Loa (eye worm) SRC-1 0.0041 0.0577 0.0576
Trypanosoma cruzi hexose transporter, putative 0.0017 0.016 0.1383
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0406 0.0617
Schistosoma mansoni protein kinase 0.0031 0.0406 0.0406
Toxoplasma gondii protein kinase, putative 0.0286 0.4928 1
Echinococcus granulosus neuroglian 0.0012 0.0069 0.0067
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0101 0.1651 0.1651
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0406 0.0404
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0257 0.0257
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0105 0.0103
Schistosoma mansoni tyrosine kinase 0.0358 0.6202 0.6202
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0413 0.1973
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0577 0.0576
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Schistosoma mansoni tyrosine kinase 0.0041 0.0577 0.0577
Echinococcus granulosus General substrate transporter 0.0087 0.1399 0.1397
Schistosoma mansoni tyrosine kinase 0.0362 0.6281 0.6281
Schistosoma mansoni tyrosine kinase 0.0572 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0107
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0109 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0016 0.0139 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.1651 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0009 0.0016 0.0016
Schistosoma mansoni tyrosine kinase 0.0362 0.6281 0.6281
Schistosoma mansoni tyrosine kinase 0.0181 0.3073 0.3073
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0577 0.0576
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.001 0.0025 0.0024
Loa Loa (eye worm) sugar transporter 0.0101 0.1651 0.165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Schistosoma mansoni cell adhesion molecule 0.001 0.0025 0.0025
Schistosoma mansoni glucose transport protein 0.0101 0.1651 0.1651
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0577 0.0576
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0484 0.051
Trypanosoma cruzi hexose transporter 0.0031 0.0413 0.8107
Entamoeba histolytica protein kinase, putative 0.0031 0.0406 0.9074
Schistosoma mansoni protein kinase 0.0031 0.0406 0.0406
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0413 0.1973
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0413 0.1973
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0434 0.0432
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0447 0.0445
Brugia malayi Protein kinase domain containing protein 0.0181 0.3073 0.3072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0513 0.0511
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0257 0.0255
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0109 0.0107
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0406 0.0404
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Onchocerca volvulus 0.0014 0.0109 0.7798
Onchocerca volvulus Netrin receptor homolog 0.0011 0.0059 0.4203
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0257 0.0201
Echinococcus multilocularis c src tyrosine kinase 0.0012 0.0066 0.0064
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0413 0.8107
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0406 0.1927
Leishmania major glucose transporter, lmgt3 0.0031 0.0413 0.8107
Echinococcus granulosus tyrosine protein kinase Lyn 0.0043 0.0612 0.061
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0395 1
Onchocerca volvulus 0.0009 0.0016 0.1049
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Echinococcus granulosus insulin receptor 0.0181 0.3073 0.3072
Onchocerca volvulus 0.0011 0.0059 0.4203
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0025 0.0024
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0181 0.3073 0.3072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0413 0.8107
Plasmodium vivax hexose transporter 0.0101 0.1651 0.2094
Echinococcus granulosus epidermal growth factor receptor 0.0362 0.6281 0.6281
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0011 0.0059 0.4203
Brugia malayi hypothetical protein 0.0014 0.0109 0.0107
Entamoeba histolytica hypothetical protein 0.0023 0.0257 0.5729
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0577 0.0576
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0012 0.0066 0.0064
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0257 0.0201
Schistosoma mansoni protein kinase 0.0031 0.0406 0.0406
Brugia malayi hypothetical protein 0.0014 0.0109 0.0107
Schistosoma mansoni titin 0.0011 0.0059 0.0059
Onchocerca volvulus 0.0014 0.0109 0.7798
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Echinococcus multilocularis neuroglian 0.0012 0.0069 0.0067
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0257 0.0255
Brugia malayi hypothetical protein 0.0014 0.0109 0.0107
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0577 0.0576
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0577 0.0576
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Echinococcus multilocularis basement membrane specific heparan sulfate 0.001 0.0025 0.0024
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.0577 0.0576
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0257 0.0961
Echinococcus multilocularis insulin receptor 0.0181 0.3073 0.3072
Schistosoma mansoni glucose transport protein 0.0101 0.1651 0.1651
Brugia malayi Sugar transporter family protein 0.0014 0.0109 0.0107
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0484 0.0779
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0406 0.0404
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0109 0.0107
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0395 0.0393
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0372 0.037
Onchocerca volvulus 0.0014 0.0109 0.7798
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0513 0.0511
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.0577 0.0576
Leishmania major glucose transporter, lmgt2 0.0031 0.0413 0.8107
Schistosoma mansoni glucose transporter 0.0014 0.0109 0.0109
Schistosoma mansoni nephrin 0.0012 0.0069 0.0069
Loa Loa (eye worm) sugar transporter 0.0014 0.0109 0.0107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0196 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0413 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Brugia malayi major facilitator superfamily protein 0.0014 0.0109 0.0107
Onchocerca volvulus 0.0014 0.0109 0.7798
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.1651 0.3201
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0012 0.0066 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0413 0.1973
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Schistosoma mansoni tyrosine kinase 0.0012 0.0066 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0406 0.0406
Schistosoma mansoni Neurotrimin precursor (hNT) 0.001 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Abl 0.0012 0.0066 0.0064
Brugia malayi Cam kinase protein 1 0.0031 0.0406 0.0404
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0109 0.2954
Mycobacterium ulcerans sugar transporter 0.0014 0.0109 0.2954
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0257 0.0255
Brugia malayi major facilitator superfamily protein 0.0014 0.0109 0.0107
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Schistosoma mansoni tyrosine kinase 0.0008 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.0577 0.0576
Brugia malayi Sugar transporter family protein 0.0014 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Entamoeba histolytica protein kinase, putative 0.0033 0.0447 1
Echinococcus multilocularis 0.0257 0.4417 0.4416
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0484 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0395 0.1855
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0109 0.0107
Onchocerca volvulus 0.0014 0.0109 0.7798
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Trypanosoma brucei glucose transporter 1E 0.0031 0.0413 0.8107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0229 0.0227
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0025 0.0024
Trypanosoma brucei glucose transporter 2A 0.0031 0.0413 0.8107
Schistosoma mansoni hypothetical protein 0.0011 0.0059 0.0059
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0257 0.0257
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0406 0.7919
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0406 0.0404
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0109 0.0107
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0406 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.001 0.0025 0.0025
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0009 0.0016 0.0014
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0406 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0406 0.0617
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0406 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Plasmodium falciparum hexose transporter 0.0101 0.1651 0.2094
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0484 1
Echinococcus granulosus epidermal growth factor receptor 0.0572 1 1
Echinococcus granulosus low density lipoprotein receptor ldl 0.0009 0.0016 0.0014
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0513 0.0511
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0257 0.5182
Brugia malayi Tyrosine-protein kinase abl-1 0.0012 0.0066 0.0064
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0406 0.0404
Onchocerca volvulus 0.0014 0.0109 0.7798
Echinococcus multilocularis Immunoglobulin 0.001 0.0025 0.0024
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0395 0.0393
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0406 0.0617
Onchocerca volvulus Putative transporter 0.0014 0.0109 0.7798
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0107
Loa Loa (eye worm) TK/INSR protein kinase 0.0181 0.3073 0.3072
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0257 0.395
Echinococcus granulosus c src tyrosine kinase 0.0012 0.0066 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0413 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Brugia malayi hypothetical protein 0.001 0.0025 0.0024
Loa Loa (eye worm) TK protein kinase 0.0037 0.0513 0.0511
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 0.7475 1
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0257 0.0255
Echinococcus multilocularis epidermal growth factor receptor 0.0362 0.6281 0.6281
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.2757 0.3595
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.003 0.0395 0.0393
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0413 0.8107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0406 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0406 0.0404
Echinococcus granulosus Immunoglobulin 0.001 0.0025 0.0024
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.0577 0.0576
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1651 0.165
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0395 1
Onchocerca volvulus 0.0014 0.0109 0.7798
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0372 0.037
Onchocerca volvulus Putative titin 0.0011 0.0059 0.4203
Brugia malayi Sugar transporter family protein 0.0101 0.1651 0.165
Schistosoma mansoni tyrosine kinase 0.0012 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0413 0.1973
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0257 0.395
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0513 0.0511
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Onchocerca volvulus 0.0014 0.0109 0.7798
Schistosoma mansoni glucose transport protein 0.0101 0.1651 0.1651
Schistosoma mansoni tyrosine kinase 0.0041 0.0577 0.0577
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0484 1
Echinococcus multilocularis epidermal growth factor receptor 0.0572 1 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Schistosoma mansoni tyrosine kinase 0.0181 0.3073 0.3073
Echinococcus granulosus roundabout 2 0.0012 0.0069 0.0067
Brugia malayi protein-tyrosine kinase 0.0037 0.0513 0.0511
Onchocerca volvulus 0.0014 0.0109 0.7798
Echinococcus multilocularis roundabout 2 0.0012 0.0069 0.0067
Echinococcus multilocularis hemicentin 1 0.0011 0.0059 0.0058
Onchocerca volvulus 0.0014 0.0109 0.7798
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0395 0.0393
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0395 0.8825
Onchocerca volvulus 0.0009 0.0016 0.1049
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0109 0.0107
Plasmodium falciparum protein kinase 6 0.043 0.7475 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Echinococcus granulosus defective proboscis extension response 0.001 0.0025 0.0024
Echinococcus multilocularis Immunoglobulin 0.001 0.0025 0.0024
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0484 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0395 0.0393
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0107
Brugia malayi SRC-1 0.0041 0.0577 0.0576
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0484 0.051
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0012 0.0066 0.0064
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0406 0.0404
Brugia malayi hypothetical protein 0.0009 0.0016 0.0014
Plasmodium falciparum protein kinase 7 0.0286 0.4928 0.6542
Schistosoma mansoni tyrosine kinase 0.0008 0.0002 0.0002
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0257 0.0308
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0107
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Schistosoma mansoni tyrosine kinase 0.0358 0.6202 0.6202
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0107
Echinococcus granulosus hemicentin 1 0.0011 0.0059 0.0058
Loa Loa (eye worm) TK/EGFR protein kinase 0.0572 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0257 1
Onchocerca volvulus 0.0014 0.0109 0.7798
Onchocerca volvulus 0.0014 0.0109 0.7798
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.1651 0.165
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.0577 0.0576
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0181 0.3073 0.3072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0362 0.6281 0.6281
Onchocerca volvulus 0.0014 0.0109 0.7798
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0067
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0107
Schistosoma mansoni sugar transporter 0.0014 0.0109 0.0109
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0406 0.0404
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0406 0.0404
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.0577 0.0576
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Echinococcus multilocularis General substrate transporter 0.0087 0.1399 0.1397
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0257 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0109 0.0107
Echinococcus granulosus contactin 0.0011 0.0059 0.0058
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0577 0.0576
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0207 0.0641
Echinococcus granulosus solute carrier family 22 0.0014 0.0109 0.0107
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0413 0.8107
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0014 0.0105 0.0103
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0406 0.0404
Schistosoma mansoni vesicular amine transporter 0.001 0.0025 0.0025
Leishmania major protein kinase, putative 0.0031 0.0406 0.7919
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0447 0.0445
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0577 0.0576
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0109 0.2954
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0257 1
Onchocerca volvulus 0.0014 0.0109 0.7798
Onchocerca volvulus 0.0014 0.0109 0.7798
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0413 0.1973
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0434 0.0432
Loa Loa (eye worm) TK protein kinase 0.0033 0.0447 0.0445
Trypanosoma brucei glucose transporter, putative 0.0031 0.0413 0.8107
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0024
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0257 0.395
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0109 0.0107
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0292
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0484 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0257 0.3046
Entamoeba histolytica protein kinase, putative 0.0031 0.0406 0.9074
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0109 0.2954
Onchocerca volvulus 0.0011 0.0059 0.4203
Onchocerca volvulus 0.0014 0.0109 0.7798
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.2757 0.3595
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0406 0.0404
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.2757 0.5495

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 3 % Inhibition of human CYP17 expressed in Escherichia coli coexpressed with NADPH-P450 reductase at 2 uM ChEMBL. 18061460
Inhibition (binding) = 3 % Inhibition of human CYP17 expressed in Escherichia coli coexpressed with NADPH-P450 reductase at 2 uM ChEMBL. 18061460
Inhibition (binding) = 5 % Inhibition of human CYP17 expressed in Escherichia coli coexpressed with NADPH-P450 reductase at 0.2 uM ChEMBL. 18061460
Inhibition (binding) = 5 % Inhibition of human CYP17 expressed in Escherichia coli coexpressed with NADPH-P450 reductase at 0.2 uM ChEMBL. 18061460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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