Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.4034 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1118 | 0.2771 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0055 | 0.0142 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0134 | 0.1553 | 0.3851 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0055 | 0.0142 | 0.0169 |
Echinococcus multilocularis | 0.0055 | 0.0142 | 0.0351 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0055 | 0.0142 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0055 | 0.0142 | 0.0169 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0055 | 0.0142 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0116 | 0.1222 | 0.3028 |
Leishmania major | UDP-galactopyranose mutase | 0.0055 | 0.0142 | 1 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0272 | 0.4034 | 0.4802 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0245 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1376 | 0.3412 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0055 | 0.0142 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0055 | 0.0142 | 0.0142 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0272 | 0.4034 | 1 |
Brugia malayi | DOMON domain containing protein | 0.0052 | 0.0082 | 0.0203 |
Mycobacterium ulcerans | oxidoreductase | 0.0055 | 0.0142 | 0.0142 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0055 | 0.0142 | 0.0351 |
Onchocerca volvulus | 0.0052 | 0.0082 | 0.0669 | |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0048 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0055 | 0.0142 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0055 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1118 | 0.2771 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0515 | 0.8401 | 1 |
Brugia malayi | DOMON domain containing protein | 0.0052 | 0.0082 | 0.0203 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0272 | 0.4034 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0549 | 0.9004 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0055 | 0.0142 | 1 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0272 | 0.4034 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0138 | 0.1626 | 0.4032 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.4034 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0055 | 0.0142 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0142 | 0.0351 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0138 | 0.1618 | 0.4011 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0048 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0055 | 0.0142 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.011 | 0.1118 | 0.2771 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1618 | 0.4011 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0138 | 0.1618 | 0.1926 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0055 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0052 | 0.0082 | 0.0203 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0055 | 0.0142 | 0.0157 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0055 | 0.0142 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0055 | 0.0142 | 0.0351 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0052 | 0.0082 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1222 | 0.3028 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0142 | 0.0351 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.011 | 0.1118 | 0.1331 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0055 | 0.0142 | 0.5 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0272 | 0.4034 | 0.4802 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0048 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0055 | 0.0142 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0604 | 1 | 1 |
Onchocerca volvulus | 0.0052 | 0.0082 | 0.0669 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.011 | 0.1118 | 0.2771 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0061 | 0.0245 | 0.0608 |
Onchocerca volvulus | 0.0116 | 0.1222 | 1 | |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0055 | 0.0142 | 1 |
Schistosoma mansoni | amine oxidase | 0.0055 | 0.0142 | 0.0169 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0048 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0055 | 0.0142 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0272 | 0.4034 | 1 |
Treponema pallidum | adenosine deaminase | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0138 | 0.1618 | 0.4011 |
Plasmodium vivax | hypothetical protein, conserved | 0.0055 | 0.0142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0142 | 0.0351 |
Brugia malayi | DOMON domain containing protein | 0.0052 | 0.0082 | 0.0203 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0052 | 0.0082 | 0.0203 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 500 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
IC50 (binding) | > 500 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
Inhibition (binding) | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx up to 500 uM after 5 mins by FLIPR assay | ChEMBL. | 23602525 | |
Inhibition (binding) | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx up to 500 uM after 5 mins by FLIPR assay | ChEMBL. | 23602525 | |
Ki (binding) | = 1000 uM | Inhibition of AmpC beta lactamase (unknown origin) | ChEMBL. | 17997318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.