Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0048 | 0.3922 | 0.4533 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.8637 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0018 | 0.0188 | 0.0251 |
Mycobacterium ulcerans | thioesterase TesA | 0.0043 | 0.3283 | 0.4398 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0054 | 0.473 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0092 | 0.9413 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0016 | 0.0012 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0076 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0076 | 0.7465 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0036 | 0.2515 | 0.5305 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | egf-like domain protein | 0.0016 | 0.0012 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.473 | 0.6337 |
Mycobacterium ulcerans | thioesterase | 0.0043 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0037 | 0.2556 | 0.3424 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0033 | 0.2116 | 0.4459 |
Echinococcus multilocularis | laminin | 0.0016 | 0.0012 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0034 | 0.2195 | 0.2941 |
Echinococcus granulosus | Tolloid protein 1 | 0.0016 | 0.0012 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.473 | 1 |
Onchocerca volvulus | 0.0048 | 0.3922 | 0.4159 | |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0054 | 0.473 | 0.6337 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0043 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0043 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0041 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0054 | 0.473 | 0.6337 |
Loa Loa (eye worm) | acyl carrier protein | 0.0023 | 0.0922 | 0.1054 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0054 | 0.473 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0034 | 0.2195 | 0.2941 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.3922 | 0.3914 |
Loa Loa (eye worm) | fatty acid synthase | 0.005 | 0.4253 | 0.4917 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.0054 | 0.473 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0041 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0051 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0054 | 0.473 | 0.6337 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0026 | 0.121 | 0.2537 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0021 | 0.0571 | 0.0765 |
Echinococcus granulosus | laminin | 0.0016 | 0.0012 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0034 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0041 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0076 | 0.7465 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0049 | 0.4144 | 0.5551 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0048 | 0.3922 | 0.5254 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0051 | 0.4337 | 0.433 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0029 | 0.1609 | 0.2155 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0076 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0042 | 0.3185 | 0.4267 |
Echinococcus multilocularis | fibrillin 1 | 0.0016 | 0.0012 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0049 | 0.4144 | 0.5551 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1557 | 0.179 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0016 | 0.0012 | 0.5 |
Onchocerca volvulus | 0.0089 | 0.9021 | 0.9582 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0051 | 0.4337 | 0.581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.