Detailed information for compound 539981

Basic information

Technical information
  • TDR Targets ID: 539981
  • Name: (4R)-4-[(7Z,8R,9S,10S,13R,14S,17R)-3-hydroxy- 7-hydroxyimino-10,13-dimethyl-1,2,3,4,5,6,8,9 ,11,12,14,15,16,17-tetradecahydrocyclopenta[a ]phenanthren-17-yl]pentanoic acid
  • MW: 405.571 | Formula: C24H39NO4
  • H donors: 3 H acceptors: 4 LogP: 4.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C\1/CC2CC(O)CC[C@@]2([C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@@]1(C)CC2)[C@@H](CCC(=O)O)C)C
  • InChi: 1S/C24H39NO4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(26)12-15(23)13-20(22)25-29/h14-19,22,26,29H,4-13H2,1-3H3,(H,27,28)/b25-20-/t14-,15?,16?,17-,18+,19+,22+,23+,24-/m1/s1
  • InChiKey: BTJWQMQHCORTED-MBKKHDIZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R)-4-[(7Z,8R,9S,10S,13R,14S,17R)-7-hydroximino-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]valeric acid
  • 3-hydroxy-7-(hydroxyimino)cholanic acid
  • 131204-64-3
  • HHCA
  • Lca-7-oxime

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.0146 0.3271 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Toxoplasma gondii sugar transporter ST2 0.0014 0.0217 0.0327
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0414 0.6849
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.1785
Brugia malayi Muscleblind-like protein 0.0146 0.3271 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0618
Giardia lamblia Sugar-proton symporter 0.0014 0.0217 0.346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 1 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0618
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0217 0.303
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0217 0.0618
Loa Loa (eye worm) sugar transporter 0.0103 0.2266 0.6912
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0611 0.1831
Plasmodium falciparum hexose transporter 0.0103 0.2266 0.2253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0016 0.0377
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0611 0.1831
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0217 0.0327
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni hypothetical protein 0.0103 0.2266 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0217 0.5239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0308 0.4309
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0308 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3734 0.5643
Leishmania major hypothetical protein, conserved 0.0014 0.0217 0.303
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0308 0.0899
Toxoplasma gondii sugar transporter ST1 0.0014 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Brugia malayi Cam kinase protein 1 0.0032 0.0611 0.1831
Onchocerca volvulus 0.0014 0.0217 0.5
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Toxoplasma gondii sugar transporter ST3 0.0014 0.0217 0.0327
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0333 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0611 0.855
Onchocerca volvulus 0.0014 0.0217 0.5
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0597 0.1785
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0134 0.4051
Onchocerca volvulus 0.0014 0.0217 0.5
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0016 0.0024
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0597 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0612 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0217 0.0618
Onchocerca volvulus 0.0014 0.0217 0.5
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0217 0.303
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Schistosoma mansoni protein kinase 0.0032 0.0611 0.2648
Brugia malayi hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus Putative transporter 0.0014 0.0217 0.5
Schistosoma mansoni ap endonuclease 0.0018 0.0308 0.13
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Mycobacterium ulcerans sugar transporter 0.0014 0.0217 0.5239
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0566 0.1692
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0348 0.1536
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0217 0.0201
Leishmania major protein kinase, putative 0.0032 0.0611 0.855
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0016 0.0024
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3734 0.3724
Brugia malayi Sugar transporter family protein 0.0103 0.2266 0.6912
Loa Loa (eye worm) hypothetical protein 0.0146 0.3271 1
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2266 0.6912
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0308 0.491
Onchocerca volvulus 0.0014 0.0217 0.5
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Schistosoma mansoni ap endonuclease 0.0018 0.0308 0.13
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0414 0.0399
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0217 0.303
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Schistosoma mansoni glucose transport protein 0.0103 0.2266 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0308 0.4309
Trypanosoma brucei glucose transporter 1E 0.0032 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Brugia malayi hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0308 0.136
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0715 0.0701
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0621 0.868
Plasmodium falciparum protein kinase 7 0.0291 0.6617 0.6612
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0308 0.4309
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0333 0.5587
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0611 0.1831
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3734 0.3724
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0308 0.0899
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0715 1
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0612 0.0597
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 1
Entamoeba histolytica hypothetical protein 0.0023 0.0414 0.6679
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0414 0.0625
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0134 0.3243
Schistosoma mansoni protein kinase 0.0032 0.0611 0.2648
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0715 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0217 0.0618
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0715 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0414 0.1826
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0134 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0414 0.1223
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0621 0.274
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0217 0.6499
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0025 0.0463 0.1373
Plasmodium vivax sugar transporter, putative 0.0014 0.0217 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0414 0.1223
Loa Loa (eye worm) hypothetical protein 0.0032 0.0611 0.1831
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0612 0.0925
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0597 0.1785
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0016 0.0262
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Onchocerca volvulus 0.0014 0.0217 0.5
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2266 0.3424
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major glucose transporter, lmgt2 0.0032 0.0621 0.868
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0414 0.6932
Toxoplasma gondii exonuclease III APE 0.0018 0.0308 0.0466
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0618
Loa Loa (eye worm) sugar transporter 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0618
Trypanosoma brucei sugar transporter, putative 0.0014 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0618
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0217 0.6873
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0612 0.0597
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0618
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0597 0.1785
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0618
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0414 0.0399
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0414 0.1223
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0597 0.1785
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0175 0.049
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0618
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0597 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0308 0.0899
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0016 0.0468
Leishmania major glucose transporter, lmgt3 0.0032 0.0621 0.868
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0286 0.3994
Giardia lamblia Hexose transporter 0.0014 0.0217 0.346
Onchocerca volvulus 0.0014 0.0217 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0308 0.9243
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0618
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0308 0.7451
Onchocerca volvulus 0.0014 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.1785
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0597 0.2583
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0618
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0217 0.0894
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0308 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0612 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0621 0.274
Echinococcus multilocularis muscleblind protein 0.0146 0.3271 1
Toxoplasma gondii protein kinase, putative 0.0291 0.6617 1
Onchocerca volvulus 0.0014 0.0217 0.5
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0217 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0618
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Echinococcus multilocularis muscleblind protein 1 0.0146 0.3271 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0612 0.0597
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0715 0.1081
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0597 0.2583
Schistosoma mansoni glucose transport protein 0.0103 0.2266 1
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0611 0.2699
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0308 0.0899
Schistosoma mansoni glucose transporter 0.0014 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0621 0.274
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0217 0.6499
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Entamoeba histolytica protein kinase, putative 0.0032 0.0611 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0308 0.4309
Schistosoma mansoni glucose transport protein 0.0103 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0414 0.1223
Brugia malayi hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0308 0.0293
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0217 0.5239
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0308 0.136
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Schistosoma mansoni protein kinase 0.0032 0.0611 0.2648
Entamoeba histolytica protein kinase, putative 0.0032 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0611 0.1831
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0146 0.3271 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0618
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0618
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0414 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0597 0.2634
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0612 0.0925
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0308 1
Plasmodium vivax hexose transporter 0.0103 0.2266 0.2253
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0016 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2266 1
Trypanosoma cruzi hexose transporter 0.0032 0.0621 0.868
Leishmania major glucose transporter, lmgt1 0.0032 0.0621 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2266 0.6912
Trypanosoma brucei glucose transporter 2A 0.0032 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0618
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0618
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0308 0.5035
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0618
Echinococcus granulosus General substrate transporter 0.0089 0.193 0.5882
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis General substrate transporter 0.0089 0.193 0.5882
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0611 0.1831
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0566 0.1692
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0612 0.0925
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0597 0.9752

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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