Detailed information for compound 540944

Basic information

Technical information
  • TDR Targets ID: 540944
  • Name: 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-y l)amino]-4-sulfo-anilino]-9,10-dioxo-anthrace ne-2-sulfonic acid
  • MW: 637.429 | Formula: C23H14Cl2N6O8S2
  • H donors: 5 H acceptors: 11 LogP: 4.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: Clc1nc(Cl)nc(n1)Nc1cc(ccc1S(=O)(=O)O)Nc1cc(c(c2c1C(=O)c1ccccc1C2=O)N)S(=O)(=O)O
  • InChi: 1S/C23H14Cl2N6O8S2/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31)
  • InChiKey: RTLULCVBFCRQKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfoanilino]-9,10-dioxo-2-anthracenesulfonic acid
  • 1-azanyl-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfo-phenyl]amino]-9,10-dioxo-anthracene-2-sulfonic acid
  • 1-amino-4-[3-[(4,6-dichloro-s-triazin-2-yl)amino]-4-sulfo-anilino]-9,10-diketo-anthracene-2-sulfonic acid
  • 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid
  • procion blue MX-R
  • 1-amino-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl]amino]-9,10-dioxoanthracene-2-sulfonic acid
  • 1-amino-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfo-phenyl]amino]-9,10-dioxo-anthracene-2-sulfonic acid
  • 1-amino-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl]amino]-9,10-dioxo-2-anthracenesulfonic acid
  • 1-amino-4-[[3-[(4,6-dichloro-s-triazin-2-yl)amino]-4-sulfo-phenyl]amino]-9,10-diketo-anthracene-2-sulfonic acid
  • 13324-20-4
  • 95328-59-9
  • 11140-86-6
  • 12225-35-3
  • 81683_FLUKA
  • R8754_SIGMA
  • 1-Amino-4-(2'-(4",6"-dichloro-s-triazin-2-yl)amino)phenylamino)9,10-dihydro-9,10-dioxoanthracene-2,4'-disulphonic acid
  • ST5411602
  • NSC364368
  • RB45_SIGMA
  • 1-Amino-4-({3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl}amino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
  • AIDS-014965
  • AIDS014965
  • 1-Amino-4-[3-(4,6-dichlorotriazin-2-ylamino)-4-sulfophenylamino]anthraquinone-2-sulfonic acid
  • 244813_SIAL
  • Procion blue MX-R®
  • 2-ANTHRACENESULFONIC ACID, 1-AMINO-4-(3-((4,6-DICHLORO-s-TRIAZIN-2-YL)AMINO)-4-S
  • 2-Anthracenesulfonic acid, 1-amino-4-((3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-
  • 2-Anthracenesulfonic acid, 1-amino-4-(3-((4,6-dichloro-s-triazin-2-yl)amino)-4-sulfoanilino)-9,10-dihydro-9,10-dioxo-
  • BRN 0602258
  • C.I. 61205
  • C.I. Reactive Blue 4
  • EINECS 236-363-9
  • Helaktyn Pure Blue FR
  • Mikacion Brilliant Blue RS
  • Modr Reaktivni 4 [Czech]
  • NSC 364368
  • Ostazin Brilliant Blue S-R
  • Procion Brilliant Blue MR
  • Procion Brilliant Blue MX-R
  • Procion Brilliant Blue RS
  • Reactive Blue 4
  • R2507_SIGMA
  • Reactive Blue- 4−Agarose

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0108 0.0494
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0307 0.0201
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 1 1
Schistosoma mansoni protein kinase 0.0032 0.0507 0.175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.2897 0.6667
Onchocerca volvulus 0.0015 0.0108 0.1816
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1217 0.5582
Plasmodium falciparum hexose transporter 0.0105 0.2179 0.2094
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0307 0.0308
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0108 0.1469
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0108 0.0248
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0108 0.0248
Brugia malayi major facilitator superfamily protein 0.0015 0.0108 0.0248
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.024 0.0641
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3664 0.5495
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.1364
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0516 0.1973
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0516 0.8107
Brugia malayi Cam kinase protein 1 0.0032 0.0507 0.1167
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0307 1
Onchocerca volvulus 0.0015 0.0108 0.1816
Onchocerca volvulus 0.0015 0.0108 0.1816
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0507 0.0404
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.4345 1
Onchocerca volvulus Putative transporter 0.0015 0.0108 0.1816
Mycobacterium tuberculosis Conserved protein 0.0036 0.0593 0.0985
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0593 0.0985
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0612 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0593 0.0985
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0492 0.7254
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Onchocerca volvulus 0.0015 0.0108 0.1816
Mycobacterium tuberculosis Conserved protein 0.0036 0.0593 0.0985
Loa Loa (eye worm) hypothetical protein 0.0031 0.0492 0.1132
Brugia malayi beta-lactamase 0.0036 0.0593 0.1364
Mycobacterium tuberculosis Conserved protein 0.0036 0.0593 0.0985
Onchocerca volvulus 0.0036 0.0593 1
Onchocerca volvulus 0.0015 0.0108 0.1816
Schistosoma mansoni glucose transport protein 0.0105 0.2179 0.7523
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0307 0.0706
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0593 0.0985
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0492 0.2257
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0593 0.9622
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0108 0.0248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2179 0.3201
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0507 0.7919
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0612 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0507 0.175
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0461 0.2116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0706
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1217 0.28
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Schistosoma mansoni hypothetical protein 0.0063 0.1217 0.42
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0507 0.0404
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0108 0.0494
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0507 0.1167
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0307 0.395
Brugia malayi beta-lactamase family protein 0.0036 0.0593 0.1364
Onchocerca volvulus 0.0036 0.0593 1
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0307 0.1408
Trypanosoma brucei glucose transporter 1E 0.0032 0.0516 0.8107
Echinococcus multilocularis solute carrier family 22 0.0015 0.0108 0.0494
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0593 0.272
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0516 0.1973
Leishmania major glucose transporter, lmgt2 0.0032 0.0516 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0307 0.5182
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0507 0.0404
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0307 0.221
Schistosoma mansoni hypothetical protein 0.0105 0.2179 0.7523
Onchocerca volvulus 0.0015 0.0108 0.1816
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.4345 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0593 0.049
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0593 0.0985
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0492 0.1855
Schistosoma mansoni protein kinase 0.0032 0.0507 0.175
Leishmania major glucose transporter, lmgt3 0.0032 0.0516 0.8107
Loa Loa (eye worm) sugar transporter 0.0105 0.2179 0.5016
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0492 0.2257
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3664 0.3595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1881 0.6494
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0507 0.0404
Schistosoma mansoni sugar transporter 0.0015 0.0108 0.0372
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0307 0.4971
Toxoplasma gondii protein kinase, putative 0.0296 0.658 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0593 0.9622
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0593 0.2046
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0507 0.0617
Schistosoma mansoni glucose transporter 0.0015 0.0108 0.0372
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0593 0.2341
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0516 0.8107
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.5033 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0177 0.1383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1881 0.8632
Loa Loa (eye worm) hypothetical protein 0.0063 0.1217 0.28
Mycobacterium ulcerans hypothetical protein 0.0036 0.0593 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2179 1
Loa Loa (eye worm) sugar transporter 0.0015 0.0108 0.0248
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0066 0.0151
Onchocerca volvulus 0.0015 0.0108 0.1816
Onchocerca volvulus 0.0036 0.0593 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0507 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0612 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1881 0.8632
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1881 0.8632
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0507 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Onchocerca volvulus 0.0015 0.0108 0.1816
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0507 0.1167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0593 0.0985
Mycobacterium ulcerans sugar transporter 0.0015 0.0108 0.1469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1881 0.6494
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0507 0.2326
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0612 0.0779
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0307 0.395
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0593 0.2341
Echinococcus granulosus solute carrier family 22 0.0015 0.0108 0.0494
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0307 0.0201
Loa Loa (eye worm) hypothetical protein 0.0026 0.0356 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0516 0.1973
Echinococcus granulosus General substrate transporter 0.009 0.184 0.8445
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0108 0.1469
Onchocerca volvulus 0.0015 0.0108 0.1816
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1881 0.433
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0516 0.1973
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0108 0.0248
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0507 0.1167
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0507 0.1927
Echinococcus granulosus solute carrier family 22 0.0015 0.0108 0.0494
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0492 0.1132
Brugia malayi hypothetical protein 0.0015 0.0108 0.0248
Schistosoma mansoni sugar transporter 0.0015 0.0108 0.0372
Schistosoma mansoni sugar transporter 0.0015 0.0108 0.0372
Schistosoma mansoni hypothetical protein 0.0063 0.1217 0.42
Echinococcus multilocularis GPCR, family 2 0.0063 0.1217 0.5582
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0108 0.0494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0492 0.1132
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0108 0.5
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0226 0.024
Echinococcus multilocularis General substrate transporter 0.009 0.184 0.8445
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Schistosoma mansoni hypothetical protein 0.0063 0.1217 0.42
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0492 0.1698
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1217 0.5582
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0226 0.024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Trypanosoma brucei glucose transporter 2A 0.0032 0.0516 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Mycobacterium leprae Probable lipase LipE 0.0036 0.0593 1
Onchocerca volvulus 0.0015 0.0108 0.1816
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0516 0.8107
Trypanosoma cruzi hexose transporter 0.0032 0.0516 0.8107
Mycobacterium ulcerans beta-lactamase 0.0036 0.0593 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0492 0.1132
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0593 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0593 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0507 0.0617
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0507 0.0404
Echinococcus granulosus solute carrier family 22 0.0015 0.0108 0.0494
Echinococcus multilocularis solute carrier family 22 0.0015 0.0108 0.0494
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.1364
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Entamoeba histolytica protein kinase, putative 0.0032 0.0507 1
Onchocerca volvulus 0.0015 0.0108 0.1816
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0307 0.395
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.1364
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0108 0.1469
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0612 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0108 0.0248
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0516 0.8107
Schistosoma mansoni sugar transporter 0.0015 0.0108 0.0372
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Echinococcus granulosus GPCR family 2 0.0063 0.1217 0.5582
Schistosoma mansoni protein kinase 0.0032 0.0507 0.175
Onchocerca volvulus 0.0015 0.0108 0.1816
Schistosoma mansoni glucose transport protein 0.0105 0.2179 0.7523
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0593 0.0985
Leishmania major hypothetical protein, conserved 0.0036 0.0593 0.9622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.1364
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0461 0.2116
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0307 0.1059
Onchocerca volvulus 0.0015 0.0108 0.1816
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0516 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0516 0.8107
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0492 0.9253
Brugia malayi major facilitator superfamily protein 0.0015 0.0108 0.0248
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1881 0.433
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0507 0.0617
Brugia malayi hypothetical protein 0.0015 0.0108 0.0248
Onchocerca volvulus 0.0015 0.0108 0.1816
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0108 0.0494
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0612 1
Brugia malayi beta-lactamase family protein 0.0036 0.0593 0.1364
Loa Loa (eye worm) hypothetical protein 0.0136 0.2897 0.6667
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0307 0.1059
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0307 0.0961
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1217 0.5582
Plasmodium falciparum protein kinase 7 0.0296 0.658 0.6542
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.4345 1
Schistosoma mansoni hypothetical protein 0.0063 0.1217 0.42
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1217 0.5582
Brugia malayi Sugar transporter family protein 0.0015 0.0108 0.0248
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3664 0.3595
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2179 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1881 0.6494
Toxoplasma gondii ABC1 family protein 0.0036 0.0593 0.0749
Brugia malayi hypothetical protein 0.0015 0.0108 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1881 0.8632
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0307 0.1408
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0593 0.2341
Echinococcus multilocularis solute carrier family 22 0.0015 0.0108 0.0494
Leishmania major glucose transporter, lmgt1 0.0032 0.0516 0.8107
Echinococcus multilocularis solute carrier family 22 0.0015 0.0108 0.0494
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0516 0.8107
Loa Loa (eye worm) hypothetical protein 0.0032 0.0507 0.1167
Trichomonas vaginalis esterase, putative 0.0036 0.0593 0.2341
Schistosoma mansoni hypothetical protein 0.0136 0.2897 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0593 0.2341
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0612 0.051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0593 0.1364
Echinococcus granulosus solute carrier family 22 0.0015 0.0108 0.0494
Leishmania major protein kinase, putative 0.0032 0.0507 0.7919
Schistosoma mansoni glucose transport protein 0.0105 0.2179 0.7523
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0507 0.0404
Onchocerca volvulus 0.0015 0.0108 0.1816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0593 0.2046
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0307 0.4971
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0516 0.1973
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0593 0.1364
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0516 0.1973
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0492 0.1698
Brugia malayi Sugar transporter family protein 0.0015 0.0108 0.0248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Plasmodium vivax hexose transporter 0.0105 0.2179 0.2094
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0516 0.1973
Trypanosoma brucei glucose transporter, putative 0.0032 0.0516 0.8107
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1217 0.28
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1217 0.28
Loa Loa (eye worm) hypothetical protein 0.0199 0.4345 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.1364
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0507 0.0404
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0108 0.0372
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0024 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0593 0.272
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0593 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0507 0.2326
Brugia malayi Sugar transporter family protein 0.0105 0.2179 0.5016
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0612 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0593 0.1364
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0593 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.1364
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0593 0.2341
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0593 0.9622
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0593 0.0985
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2179 1
Onchocerca volvulus 0.0015 0.0108 0.1816
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0507 0.0404
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0492 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0248

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.