Detailed information for compound 54463

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 541.571 | Formula: C23H31N3O10S
  • H donors: 5 H acceptors: 7 LogP: 0.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@@H]1CSCc2c(O)cccc2C(=O)OCC(C(=O)N1)NC(=O)[C@@H](NC(=O)OC(C)(C)C)CO
  • InChi: 1S/C23H31N3O10S/c1-23(2,3)36-22(33)26-14(8-27)18(29)24-15-9-35-20(31)12-6-5-7-17(28)13(12)10-37-11-16(21(32)34-4)25-19(15)30/h5-7,14-16,27-28H,8-11H2,1-4H3,(H,24,29)(H,25,30)(H,26,33)/t14-,15?,16-/m0/s1
  • InChiKey: UJFAOEXXDNALOU-AQOJYXMDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0021 0.0115 0.0115
Brugia malayi Transient-receptor-potential like protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni two-pore calcium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0115 0.0115
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0019 0.0088 0.0088
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis conserved hypothetical protein 0.0021 0.0115 0.0115
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0021 0.0115 0.0033
Trichomonas vaginalis STE family protein kinase 0.0492 0.822 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis kinase protein 0.0587 0.9848 0.9848
Giardia lamblia Kinase, NEK 0.0014 0.0005 0.0006
Echinococcus multilocularis activin receptor type 0.0019 0.0088 0.0088
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0492 0.822 1
Echinococcus granulosus two pore calcium channel protein 1 0.0021 0.0115 0.0115
Schistosoma mansoni 60S ribosomal protein L21 0.0021 0.0115 0.0134
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0115 0.0115
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0115 0.014
Brugia malayi cation channel family protein 0.0021 0.0115 0.0115
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0115 0.0072
Schistosoma mansoni transient receptor potential channel 0.0021 0.0115 0.0134
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0021 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0587 0.9848 0.9848
Schistosoma mansoni vesicular amine transporter 0.0021 0.0115 0.0134
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0115 0.0115
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0115 0.0134
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase 0.0233 0.3773 0.3773
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis transient receptor potential gamma protein 0.0021 0.0115 0.0115
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis two pore calcium channel protein 1 0.0021 0.0115 0.0115
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0115 0.0115
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0115 0.0115
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0119 0.0119
Echinococcus granulosus TRP transient receptor potential channel 0.0021 0.0115 0.0115
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0233 0.3773 0.4531
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0021 0.0115 0.0115
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0115 0.0115
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0115 0.0072
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0021 0.0115 1
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0021 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0596 1 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0021 0.0115 0.0115
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0492 0.822 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0233 0.3773 0.4531
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0021 0.0115 0.0033
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0492 0.822 1
Echinococcus granulosus two pore calcium channel protein 2 0.0021 0.0115 0.0115
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0233 0.3773 0.3773
Echinococcus multilocularis two pore calcium channel protein 2 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Leishmania major hypothetical protein, conserved 0.0021 0.0115 0.0033
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0021 0.0115 0.0134
Echinococcus granulosus mitogen activated protein kinase 3 0.0233 0.3773 0.3773
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0115 0.0115
Echinococcus granulosus potassium large conductance calcium activated 0.0021 0.0115 0.0115
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0115 0.0115
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0021 0.0115 0.0033
Trypanosoma brucei protein kinase, putative 0.0233 0.3773 0.4531
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0115 0.0115
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0115 0.0134
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0115 0.0134
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0021 0.0115 0.0115
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0115 0.0134
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0021 0.0115 0.0134
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0021 0.0115 0.0115
Echinococcus multilocularis voltage dependent calcium channel 0.0021 0.0115 0.0115
Brugia malayi MAP kinase sur-1 0.0233 0.3773 0.3773
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0233 0.3773 0.4531
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0021 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0021 0.0115 0.0115
Echinococcus multilocularis calcium activated potassium channel 0.0026 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0115 0.0115
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0115 0.0134
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0587 0.9848 0.9848
Schistosoma mansoni protein kinase 0.0019 0.0088 0.0102
Brugia malayi olfactory channel protein osm-9 0.0021 0.0119 0.0119
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0115 0.0115
Schistosoma mansoni protein kinase 0.0019 0.0088 0.0102
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0115 0.0115
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0115 0.0115
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0115 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.3773 0.4586
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0021 0.0115 0.0115
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0115 0.0115
Echinococcus multilocularis tyrosine protein kinase shark 0.0014 0.0005 0.0005
Schistosoma mansoni transient receptor potential channel 0.0021 0.0115 0.0134
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0115 0.0115
Echinococcus granulosus activin receptor type 0.0019 0.0088 0.0088
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0115 0.0115
Loa Loa (eye worm) voltage-gated calcium channel 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0115 0.0115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0233 0.3773 0.4531
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0115 0.0115
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0021 0.0115 0.0115
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0596 1 1
Brugia malayi cation channel family protein 0.0021 0.0115 0.0115
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0021 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0115 0.0115
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0021 0.0115 0.0033
Trichomonas vaginalis STE family protein kinase 0.0492 0.822 1
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Onchocerca volvulus 0.0021 0.0115 1
Schistosoma mansoni transient receptor potential channel 0.0021 0.0119 0.014
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0115 0.0115
Echinococcus multilocularis mitogen activated protein kinase 3 0.0233 0.3773 0.3773
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0019 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0115 0.0115
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0021 0.0115 0.0033
Loa Loa (eye worm) voltage-dependent calcium channel 0.0021 0.0115 0.0115
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0115 0.0072
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0115 0.0134
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0587 0.9848 0.9848
Trichomonas vaginalis CMGC family protein kinase 0.0233 0.3773 0.4589
Brugia malayi Cyclic-nucleotide gated cation channel 0.0021 0.0115 0.0115
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0115 0.0115
Toxoplasma gondii hypothetical protein 0.0021 0.0115 0.0072
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0587 0.9848 0.9848
Echinococcus granulosus sodium channel protein 0.0021 0.0115 0.0115
Echinococcus granulosus voltage gated hydrogen channel 1 0.0021 0.0115 0.0115
Echinococcus granulosus tyrosine protein kinase shark 0.0014 0.0005 0.0005
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0021 0.0115 0.0115
Brugia malayi voltage-dependent calcium channel 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0021 0.0115 0.0115
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0119 0.0119
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0233 0.3773 0.4531
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni ryanodine receptor related 0.0021 0.0115 0.0134
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0021 0.0115 0.0115
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0115 0.0115
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0021 0.0115 0.0134
Echinococcus granulosus dual specificity mitogen activated protein 0.0492 0.822 0.822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0492 0.822 0.822
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0596 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0021 0.0115 0.0115
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0119 0.0119
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0115 0.014
Trichomonas vaginalis CMGC family protein kinase 0.0233 0.3773 0.4589
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0115 0.0134
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis dual specificity mitogen activated protein 0.0492 0.822 0.822
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0021 0.0115 0.0115
Schistosoma mansoni protein kinase 0.0492 0.822 1
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus granulosus ryanodine receptor 44f 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0021 0.0115 0.0115
Echinococcus granulosus sodium leak channel non selective protein 0.0021 0.0115 0.0115
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0115 0.0115
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium large conductance calcium activated 0.0021 0.0115 0.0115
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0021 0.0115 0.0115
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0492 0.822 0.822
Loa Loa (eye worm) ryanodine receptor 0.0021 0.0115 0.0115
Trichomonas vaginalis STE family protein kinase 0.0492 0.822 1
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Giardia lamblia Kinase, STE STE20 0.0492 0.822 1
Loa Loa (eye worm) ion channel NompC 0.0021 0.0115 0.0115
Echinococcus multilocularis sodium leak channel non selective protein 0.0021 0.0115 0.0115
Echinococcus multilocularis sodium channel protein 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0021 0.0115 0.0115
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0021 0.0115 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0134
Echinococcus multilocularis kinase protein 0.0587 0.9848 0.9848
Schistosoma mansoni voltage-gated cation channel 0.0021 0.0115 0.0134
Echinococcus granulosus calcium activated potassium channel 0.0026 0.0203 0.0203
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0021 0.0115 0.0115
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0021 0.0115 0.0115
Echinococcus multilocularis voltage dependent calcium channel 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0119
Echinococcus granulosus mitogen activated protein kinase 0.0233 0.3773 0.3773
Echinococcus multilocularis transfer RNA-Gly 0.0021 0.0115 0.0115
Echinococcus granulosus transient receptor potential gamma protein 0.0021 0.0115 0.0115
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0115 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0233 0.3773 0.4589
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0021 0.0115 0.0072
Toxoplasma gondii hypothetical protein 0.0021 0.0115 0.0072
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0115 0.0115
Echinococcus granulosus tyrosine protein kinase Lyn 0.0019 0.0088 0.0088
Echinococcus granulosus hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0115 0.0115
Echinococcus multilocularis ryanodine receptor 44f 0.0021 0.0115 0.0115
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0115 0.0134
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0119 0.0119
Trichomonas vaginalis CMGC family protein kinase 0.0233 0.3773 0.4589
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0587 0.9848 0.9848
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Brugia malayi ion channel NompC 0.0021 0.0115 0.0115
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0021 0.0115 0.0115
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-dependent calcium channel 0.0021 0.0115 0.0134
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0233 0.3773 0.4531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0115 0.0134
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0115 0.0115
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0587 0.9848 0.9848
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0115 0.0115
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0021 0.0115 0.0115
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0021 0.0115 0.0115
Entamoeba histolytica protein kinase domain containing protein 0.0019 0.0088 1
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0115 0.0115
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0021 0.0115 0.0134
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0021 0.0115 0.0072
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0115 0.0115
Echinococcus granulosus shaker cognate 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0115 0.0115
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0115 0.0134
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0233 0.3773 0.4531
Loa Loa (eye worm) calcium channel 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated ion channel 0.0021 0.0115 0.0134
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Echinococcus multilocularis shaker cognate 0.0021 0.0115 0.0115
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Plasmodium falciparum protein kinase, putative 0.0019 0.0088 0.5
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0021 0.0115 0.0134
Giardia lamblia Kinase, CMGC MAPK 0.0233 0.3773 0.4589
Leishmania major hypothetical protein, unknown function 0.0021 0.0115 0.0033
Schistosoma mansoni protein kinase 0.0019 0.0088 0.0102
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0021 0.0115 0.0115
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0233 0.3773 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0115 0.0115
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0115 0.0115
Schistosoma mansoni transient receptor potential channel 4 0.0021 0.0115 0.0134

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration against Neisseria meningitides 69480 ChEMBL. 14998336
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration against Micrococcus luteus ATCC8340 ChEMBL. 14998336
MNEC (binding) = 0.4 ug ml-1 Maximum noneffective concentration of the compound against E. coli DNA gyrase ChEMBL. 14998336
MNEC (binding) = 0.4 ug ml-1 Maximum noneffective concentration of the compound against E. coli DNA gyrase ChEMBL. 14998336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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