Detailed information for compound 546930

Basic information

Technical information
  • TDR Targets ID: 546930
  • Name: 1-(1-adamantyl)ethanamine hydrochloride
  • MW: 215.763 | Formula: C12H22ClN
  • H donors: 1 H acceptors: 0 LogP: 3.42 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C12CC3CC(C2)CC(C1)C3)N.Cl
  • InChi: 1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
  • InChiKey: OZBDFBJXRJWNAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(1-adamantyl)ethylamine hydrochloride
  • Rimantadine
  • 1501-84-4
  • MLS000069661
  • SMR000059215
  • 390593_ALDRICH
  • SR-01000631468-1
  • D00901
  • 1-(1-Aminoethyl)adamantane hydrochloride
  • 1-ADAMANTANEMETHYLAMINE, alpha-METHYL-, HYDROCHLORIDE
  • Adamantane, 1-(1-aminoethyl)-, hydrochloride
  • EXP 126
  • Flumadine
  • JP 61
  • Meradane
  • NSC 206764
  • Rimantadine hydrochloride [USAN]
  • Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, hydrochloride (9CI)
  • alpha-Methyl-1-adamantanemethylamine hydrochloride
  • alpha-Methyltricyclo(3.3.1.1(sup 3,7))decane-1-methanamine hydrochloride
  • SBB003389
  • EXP-126
  • .alpha.-Methyl-1-adamantanemethylamine hydrochloride
  • 1-Adamantanemethylamine, .alpha.-methyl-, hydrochloride
  • Meradan
  • NSC206764
  • Remantadine
  • Flumadine (TN)
  • Tricyclo[3.3.1.13,7]-decane-1-methanamine, .alpha.-methyl-, hydrochloride
  • Tricyclo[3.3.1.13,7]decane-1-methanamine, .alpha.-methyl-, hydrochloride
  • C08094
  • Rimantadine hydrochloride
  • Roflual
  • Rimantadine hydrochloride (USAN)
  • 1-Adamantan-1-yl-ethylamine
  • MLS000332981
  • SMR000436311
  • Oclovir
  • Remantadine hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens androgen receptor Starlite/ChEMBL No references
Trypanosoma cruzi P-type H+-ATPase, putative Curated by TDR Targets No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Trypanosoma cruzi P-type H+-ATPase, putative Curated by TDR Targets No references
Trypanosoma cruzi P-type H+-ATPase, putative Curated by TDR Targets No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi P-type H+-ATPase, putative Get druggable targets OG5_248502 All targets in OG5_248502
Trypanosoma cruzi proton motive ATPase 1, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania mexicana P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania braziliensis P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Candida albicans adenosine triphosphatase Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania mexicana P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma brucei P-type H+-ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma brucei gambiense P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania infantum P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania major P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania infantum P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Toxoplasma gondii E1-E2 ATPase subfamily protein Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania major P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma brucei P-type H+-ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania donovani P-type H+-ATPase 1B, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma cruzi P-type H+-ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania braziliensis P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma cruzi P-type H+-ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Neospora caninum ATPase, related Get druggable targets OG5_127253 All targets in OG5_127253
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Trypanosoma cruzi proton motive ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Candida albicans adenosine triphosphatase Get druggable targets OG5_127253 All targets in OG5_127253
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Toxoplasma gondii P-type ATPase PMA1 Get druggable targets OG5_127253 All targets in OG5_127253
Leishmania infantum P-type H -ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
Trypanosoma congolense P-type H+-ATPase, putative Get druggable targets OG5_127253 All targets in OG5_127253
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei P-type H+-ATPase, putative P-type H+-ATPase, putative 259 aa 239 aa 83.3 %
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 P-type H+-ATPase, putative 898 aa 742 aa 24.7 %
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA P-type H+-ATPase, putative 645 aa 579 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0697947 0.0748274 0.997973
Schistosoma mansoni cell adhesion molecule 0.0285029 0.0256825 0.342538
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0609328 0.06428 0.854998
Brugia malayi Immunoglobulin I-set domain containing protein 0.0306595 0.0282493 0.19148
Trypanosoma cruzi aurora B kinase, putative 0.0699204 0.074977 1
Schistosoma mansoni vesicular amine transporter 0.0237352 0.020008 0.266855
Brugia malayi Carboxylesterase family protein 0.00831571 0.00165598 0.0031861
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0219963 0.0179383 0.118473
Echinococcus granulosus Immunoglobulin 0.0237352 0.020008 0.0188247
Toxoplasma gondii RNA-directed DNA polymerase 0.0571986 0.0598357 0.794753
Loa Loa (eye worm) hypothetical protein 0.0237352 0.020008 0.25487
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0394651 0.0387295 0.0375688
Echinococcus granulosus aurora kinase A 0.0699204 0.074977 0.0738601
Echinococcus multilocularis acetylcholinesterase 0.0492154 0.0503342 0.665956
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0306595 0.0282493 0.366584
Loa Loa (eye worm) hypothetical protein 0.0492154 0.0503342 0.665956
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0418504 0.0415684 0.547132
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0699204 0.074977 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0484877 0.0494681 0.654216
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00831571 0.00165598 0.0220865
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.00886198 0.00230613 0.00778955
Loa Loa (eye worm) carboxylesterase 0.00831571 0.00165598 0.00609973
Schistosoma mansoni serine/threonine protein kinase 0.0699204 0.074977 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0573497 0.0600155 0.79719
Loa Loa (eye worm) carboxylesterase 0.00831571 0.00165598 0.00609973
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0699204 0.074977 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0285029 0.0256825 0.024506
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0237352 0.020008 0.266855
Trichomonas vaginalis AGC family protein kinase 0.0699204 0.074977 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0394651 0.0387295 0.508648
Loa Loa (eye worm) hypothetical protein 0.0394651 0.0387295 0.508648
Loa Loa (eye worm) hypothetical protein 0.0214677 0.0173093 0.218287
Echinococcus multilocularis Immunoglobulin 0.0237352 0.020008 0.25487
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0571986 0.0598357 0.794753
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0699204 0.074977 1
Brugia malayi serine/threonine protein kinase 6 0.0699204 0.074977 0.522335
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0203827 0.0160179 0.200782
Schistosoma mansoni gliotactin 0.00831571 0.00165598 0.0220865
Echinococcus multilocularis para nitrobenzyl esterase 0.00831571 0.00165598 0.00609973
Leishmania major telomerase reverse transcriptase, putative 0.0571986 0.0598357 0.794753
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0609328 0.06428 0.854998
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0699204 0.074977 1
Entamoeba histolytica hypothetical protein 0.0484877 0.0494681 0.654216
Loa Loa (eye worm) hypothetical protein 0.0237352 0.020008 0.25487
Trichomonas vaginalis AGC family protein kinase 0.0699204 0.074977 1
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Echinococcus granulosus twitchin 0.0243066 0.0206881 0.0195056
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.00831571 0.00165598 0.00609973
Echinococcus granulosus BC026374 protein S09 family 0.00831571 0.00165598 0.000450527
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.00831571 0.00165598 0.5
Entamoeba histolytica protein kinase , putative 0.0699204 0.074977 1
Leishmania major protein kinase, putative 0.0699204 0.074977 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0492154 0.0503342 0.671329
Brugia malayi Carboxylesterase family protein 0.0492154 0.0503342 0.347852
Echinococcus granulosus roundabout 2 0.0285029 0.0256825 0.024506
Loa Loa (eye worm) hypothetical protein 0.0285029 0.0256825 0.33179
Loa Loa (eye worm) hypothetical protein 0.0237352 0.020008 0.25487
Plasmodium falciparum telomerase reverse transcriptase 0.0571986 0.0598357 0.794753
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0237352 0.020008 0.266855
Loa Loa (eye worm) phosphatidylinositol 3 0.0185787 0.0138708 0.171677
Brugia malayi Carboxylesterase family protein 0.00831571 0.00165598 0.0031861
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0609328 0.06428 0.854998
Brugia malayi Telomerase reverse transcriptase 0.126603 0.142439 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0571986 0.0598357 0.794753
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0699204 0.074977 0.0738601
Plasmodium falciparum serine/threonine protein kinase, putative 0.0699204 0.074977 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.00831571 0.00165598 0.5
Loa Loa (eye worm) hypothetical protein 0.0285029 0.0256825 0.33179
Echinococcus multilocularis aurora kinase A 0.0699204 0.074977 1
Trichomonas vaginalis AGC family protein kinase 0.0699204 0.074977 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0237352 0.020008 0.25487
Echinococcus granulosus para nitrobenzyl esterase 0.00831571 0.00165598 0.000450527
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.183801 0.210516 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0697947 0.0748274 0.0737103
Brugia malayi hypothetical protein 0.0237352 0.020008 0.133127
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0609328 0.06428 0.854998
Mycobacterium tuberculosis Carboxylesterase LipT 0.00831571 0.00165598 0.5
Mycobacterium ulcerans carboxylesterase, LipT 0.00831571 0.00165598 0.5
Echinococcus granulosus acetylcholinesterase 0.0492154 0.0503342 0.0491876
Brugia malayi Carboxylesterase family protein 0.00831571 0.00165598 0.0031861
Echinococcus multilocularis BC026374 protein (S09 family) 0.00831571 0.00165598 0.00609973
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0183074 0.0135479 0.0123568
Echinococcus granulosus carboxylesterase 5A 0.0492154 0.0503342 0.0491876
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0203827 0.0160179 0.200782
Echinococcus granulosus defective proboscis extension response 0.0237352 0.020008 0.0188247
Loa Loa (eye worm) AUR protein kinase 0.0699204 0.074977 1
Loa Loa (eye worm) AUR protein kinase 0.0699204 0.074977 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203827 0.0160179 0.200782
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0609328 0.06428 0.854998
Schistosoma mansoni protein kinase 0.0699204 0.074977 1
Trichomonas vaginalis spcc417.12 protein, putative 0.00831571 0.00165598 0.00609973
Giardia lamblia Telomerase catalytic subunit 0.0571986 0.0598357 0.771484
Echinococcus multilocularis roundabout 2 0.0285029 0.0256825 0.33179
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0294053 0.0267565 0.272246
Trichomonas vaginalis AGC family protein kinase 0.0699204 0.074977 1
Loa Loa (eye worm) hypothetical protein 0.0285029 0.0256825 0.33179
Echinococcus multilocularis Immunoglobulin 0.0237352 0.020008 0.25487
Loa Loa (eye worm) carboxylesterase 0.0492154 0.0503342 0.665956
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0609328 0.06428 0.446595
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.02702 0.0239176 0.307866
Brugia malayi Fibronectin type III domain containing protein 0.0237352 0.020008 0.133127
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0609328 0.06428 0.854998
Entamoeba histolytica protein kinase, putative 0.0699204 0.074977 1
Echinococcus multilocularis neuroglian 0.0237352 0.020008 0.25487
Giardia lamblia Aurora kinase 0.0699204 0.074977 1
Trypanosoma brucei telomerase reverse transcriptase 0.0571986 0.0598357 0.794753
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0203827 0.0160179 0.200782
Loa Loa (eye worm) hypothetical protein 0.0237352 0.020008 0.25487
Echinococcus granulosus neuroligin 0.00831571 0.00165598 0.000450527
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0699204 0.074977 1
Echinococcus granulosus acetylcholinesterase 0.0492154 0.0503342 0.0491876
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.847129 1 1
Brugia malayi Carboxylesterase family protein 0.00831571 0.00165598 0.0031861
Echinococcus multilocularis neuroligin 0.00831571 0.00165598 0.00609973
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.00793763 0.00120599 0.0160848
Schistosoma mansoni BC026374 protein (S09 family) 0.00831571 0.00165598 0.0220865
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0183074 0.0135479 0.1673
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203827 0.0160179 0.104875
Echinococcus multilocularis carboxylesterase 5A 0.0492154 0.0503342 0.665956
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0185787 0.0138708 0.171677
Brugia malayi hypothetical protein 0.00831571 0.00165598 0.0031861
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0203827 0.0160179 0.200782
Loa Loa (eye worm) acetylcholinesterase 1 0.0492154 0.0503342 0.665956
Schistosoma mansoni acetylcholinesterase 0.00831571 0.00165598 0.0220865
Plasmodium vivax telomerase reverse transcriptase, putative 0.0571986 0.0598357 0.794753
Echinococcus granulosus family S9 non peptidase ue S09 family 0.00831571 0.00165598 0.000450527
Toxoplasma gondii aurora kinase 0.0699204 0.074977 1
Trypanosoma brucei aurora B kinase 0.0699204 0.074977 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00831571 0.00165598 0.0220865
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0418504 0.0415684 0.547132
Echinococcus granulosus neuroglian 0.0237352 0.020008 0.0188247
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.00831571 0.00165598 0.00609973
Schistosoma mansoni phosphatidylinositol 4-kinase 0.00793763 0.00120599 0.0160848
Brugia malayi Immunoglobulin I-set domain containing protein 0.0237352 0.020008 0.133127
Loa Loa (eye worm) hypothetical protein 0.0237352 0.020008 0.25487
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0203827 0.0160179 0.213638
Schistosoma mansoni nephrin 0.0237352 0.020008 0.266855
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0394651 0.0387295 0.265685
Entamoeba histolytica protein kinase domain containing protein 0.0699204 0.074977 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.00831571 0.00165598 0.0220865
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00831571 0.00165598 0.0220865
Brugia malayi serine/threonine kinase 12 0.0699204 0.074977 0.522335
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0203827 0.0160179 0.200782
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0591288 0.0621329 0.825893
Echinococcus multilocularis acetylcholinesterase 0.0492154 0.0503342 0.665956
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Loa Loa (eye worm) hypothetical protein 0.0492154 0.0503342 0.665956
Brugia malayi serine/threonine-protein kinase 6 0.0699204 0.074977 0.522335
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0697947 0.0748274 0.998005
Loa Loa (eye worm) hypothetical protein 0.0219963 0.0179383 0.226815
Brugia malayi Carboxylesterase family protein 0.0492154 0.0503342 0.347852
Loa Loa (eye worm) hypothetical protein 0.00831571 0.00165598 0.00609973
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203827 0.0160179 0.200782
Loa Loa (eye worm) AUR protein kinase 0.0699204 0.074977 1
Entamoeba histolytica protein kinase, putative 0.0699204 0.074977 1
Loa Loa (eye worm) hypothetical protein 0.0237352 0.020008 0.25487

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.04 uM Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 ChEMBL. 18281929
IC90 (functional) = 13.97 uM Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 ChEMBL. 18281929
Potency (functional) 0.4467 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.6822 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 18281929
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23
Trypanosoma brucei ChEMBL23 18281929

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased (PATO:0000468) epimastigote (BTO:0000409) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 49870  
Annotator: millerja@u.washington.edu Comment: Note: manuscript suggested mode of action against proton-translocating, membrane-localized ATPases (H+-ATPases); surveyed GeneDB and selected four genes that most closely matched this description. Link perhaps too weak to include? References: 10103219
growth (GO:0040007) decreased (PATO:0000468) epimastigote (BTO:0000409) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 44272  
Annotator: millerja@u.washington.edu Comment: Note: manuscript suggested mode of action against proton-translocating, membrane-localized ATPases (H+-ATPases); surveyed GeneDB and selected four genes that most closely matched this description. Link perhaps too weak to include? References: 10103219
growth (GO:0040007) decreased (PATO:0000468) epimastigote (BTO:0000409) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 31958  
Annotator: millerja@u.washington.edu Comment: Note: manuscript suggested mode of action against proton-translocating, membrane-localized ATPases (H+-ATPases); surveyed GeneDB and selected four genes that most closely matched this description. Link perhaps too weak to include? References: 10103219

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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