Detailed information for compound 547280

Basic information

Technical information
  • TDR Targets ID: 547280
  • Name: 1-O-(fucopyranosyl-(4'-sulfate))-5-spirostane -1,3-diol
  • MW: 658.84 | Formula: C33H54O11S
  • H donors: 4 H acceptors: 6 LogP: 4.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2([C@@H](C1)O[C@H]1O[C@@H](C)[C@H]([C@H]([C@@H]1O)O)OS(=O)(=O)O)C)CC[C@]1([C@H]3CC2[C@@H]1[C@@H](C1(O2)CC[C@@H](CO1)C)C)C
  • InChi: 1S/C33H54O11S/c1-16-8-11-33(40-15-16)17(2)26-24(43-33)14-23-21-7-6-19-12-20(34)13-25(32(19,5)22(21)9-10-31(23,26)4)42-30-28(36)27(35)29(18(3)41-30)44-45(37,38)39/h16-30,34-36H,6-15H2,1-5H3,(H,37,38,39)/t16-,17-,18-,19-,20+,21+,22-,23-,24?,25+,26-,27-,28-,29+,30+,31-,32-,33?/m0/s1
  • InChiKey: VEBWDEUHONOFKN-BEPJGEAPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 151589-15-0
  • 1-O-Fucso4-ssd
  • Brisbagenin fucoside-4-(hydrogen sulfate)
  • beta-L-Galactopyranoside, (1beta,3beta,5alpha,25R)-3-hydroxyspirostan-1-yl 6-deoxy-, 4-(hydrogen sulfate)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0278 0.1855
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0295 0.5889
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.1918
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0295 0.1973
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0085 0.027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0034 0.0686
Schistosoma mansoni microtubule-associated protein tau 0.0674 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0501 0.335
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0255 0.0255
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0501 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0034 0.0686
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0501 0.0501
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0501 0.0501
Onchocerca volvulus 0.002 0.0054 0.1899
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0034 1
Entamoeba histolytica protein kinase, putative 0.0036 0.0296 0.5603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0054 0.0364
Plasmodium falciparum protein kinase 7 0.0324 0.4682 0.6546
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0287 0.0287
Plasmodium falciparum proline--tRNA ligase 0.004 0.0364 0.0509
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0295 0.5889
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0296 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0054 0.0364
Schistosoma mansoni glucose transport protein 0.0115 0.1496 0.1496
Trypanosoma cruzi hexose transporter 0.0036 0.0295 0.5889
Schistosoma mansoni hypothetical protein 0.0123 0.1624 0.1624
Loa Loa (eye worm) hypothetical protein 0.0036 0.0296 0.1978
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0295 0.1973
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0296 0.1978
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0096 0.0641
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Entamoeba histolytica hypothetical protein 0.0026 0.0144 0.2344
Schistosoma mansoni ap endonuclease 0.0018 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0054 0.0364
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0287 0.091
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0501 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0054 0.0054
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0144 0.2869
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0501 0.335
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.1496 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0296 0.0633
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0501 0.335
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0296 0.0414
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0295 0.5889
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0287 0.1918
Echinococcus granulosus General substrate transporter 0.0098 0.1252 0.1252
Echinococcus multilocularis microtubule associated protein 2 0.0674 1 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0501 0.0501
Mycobacterium ulcerans lipase LipD 0.0035 0.0287 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0034 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0054 0.0364
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0054 0.0054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0501 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0296 0.1978
Loa Loa (eye worm) sugar transporter 0.0115 0.1496 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0296 0.5905
Schistosoma mansoni protein kinase 0.0036 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0054 0.0364
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0144 0.2904
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Mycobacterium ulcerans beta-lactamase 0.0035 0.0287 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0287 0.091
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0287 0.0287
Plasmodium falciparum hexose transporter 0.0115 0.1496 0.2092
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0144 0.5012
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0287 0.0401
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0054 0.0054
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0222 0.0222
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0222 0.0222
Plasmodium vivax hexose transporter 0.0115 0.1496 0.2092
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0054 0.0054
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0255 0.0255
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0054 0.1899
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0034 0.023
Schistosoma mansoni thyroid hormone receptor 0.0143 0.1923 0.1923
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0501 0.0501
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0054 0.0054
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0054 0.1899
Onchocerca volvulus 0.0035 0.0287 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0054 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0295 0.1973
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0144 0.0961
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0054 0.0054
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0144 0.2869
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0054 0.0054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0287 0.1918
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0287 1
Echinococcus multilocularis General substrate transporter 0.0098 0.1252 0.1252
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0287 0.1918
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0364 0.7264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3153 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0054 0.0364
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.1918
Echinococcus granulosus GPCR family 2 0.0031 0.0222 0.0222
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0034 0.5
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0222 0.1484
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0278 0.0278
Brugia malayi Sugar transporter family protein 0.0115 0.1496 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.1918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0054 0.0364
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0144 0.0307
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0296 0.0633
Brugia malayi nuclear receptor NHR-88 0.002 0.0054 0.0364
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0054 0.0054
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0764 0.5105
Schistosoma mansoni hypothetical protein 0.0115 0.1496 0.1496
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0501 0.0501
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0364 0.0778
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0186 0.2576 0.5502
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0296 0.1978
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Onchocerca volvulus 0.0035 0.0287 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0364 0.7264
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0296 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0054 0.0364
Brugia malayi beta-lactamase family protein 0.0035 0.0287 0.1918
Leishmania major hypothetical protein, conserved 0.0035 0.0287 0.5725
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.1923 0.1923
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0295 0.1973
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0186 0.2576 0.3602
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0295 0.1973
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0034 0.0048
Loa Loa (eye worm) hypothetical protein 0.0066 0.0764 0.5105
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0054 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0287 0.1918
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0054 0.0364
Toxoplasma gondii protein kinase, putative 0.0324 0.4682 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0295 0.5889
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0278 0.5209
Brugia malayi ecdysteroid receptor 0.002 0.0054 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0054 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0054 0.0364
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0501 0.0501
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0501 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0287 0.0287
Toxoplasma gondii ABC1 family protein 0.0035 0.0287 0.0613
Schistosoma mansoni ap endonuclease 0.0018 0.0034 0.0034
Trypanosoma brucei glucose transporter 2A 0.0036 0.0295 0.5889
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0054 0.0054
Toxoplasma gondii facilitative glucose transporter GT1 0.0115 0.1496 0.3196
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0501 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0054 0.0364
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Plasmodium falciparum protein kinase 6 0.0487 0.7153 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0278 0.1855
Plasmodium falciparum protein kinase 5 0.0049 0.0501 0.0701
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0287 0.091
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0278 0.9533
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0287 0.5725
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0054 0.0364
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0295 0.1973
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Leishmania major protein kinase, putative 0.0036 0.0296 0.5905
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0296 0.1978
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0287 0.091
Schistosoma mansoni thyroid hormone receptor 0.0143 0.1923 0.1923
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.1918
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0501 0.335
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0501 0.107
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0296 0.0414
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0034 0.023
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0085 0.027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0054 0.0054
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0144 0.0201
Schistosoma mansoni protein kinase 0.0036 0.0296 0.0296
Plasmodium vivax CDK-related protein kinase 6, putative 0.0487 0.7153 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0296 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0054 0.0364
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0054 0.0054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0034 0.0034
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0296 0.0414
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0144 0.0144
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0144 0.0961
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.1855
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1624 0.1624
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0295 0.5889
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0034 0.023
Brugia malayi beta-lactamase 0.0035 0.0287 0.1918
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0054 0.0054
Brugia malayi Protein kinase domain containing protein 0.0049 0.0501 0.335
Mycobacterium ulcerans hypothetical protein 0.0035 0.0287 1
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0295 0.5889
Trypanosoma cruzi hexose transporter, putative 0.0019 0.005 0.1005
Schistosoma mansoni coup transcription factor 0.002 0.0054 0.0054
Brugia malayi nuclear hormone receptor 0.002 0.0054 0.0364
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0144 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1624 0.1624
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0501 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.1918
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0054 0.1899
Leishmania major glucose transporter, lmgt2 0.0036 0.0295 0.5889
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0054 0.0364
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0278 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0054 0.0364
Loa Loa (eye worm) hypothetical protein 0.0097 0.1231 0.8225
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0364 0.7264
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0054 0.0364
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0295 0.5889
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0115 0.1496 0.1496
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0144 0.2869
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0054 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1231 0.8225
Brugia malayi Cam kinase protein 1 0.0036 0.0296 0.1978
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0144 0.0144
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0364 0.7264
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0034 0.0686
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0287 1
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0501 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0296 0.0414
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0501 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0501 0.335
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0054 0.0364
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.1918
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0296 0.0414
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0054 0.0054
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0278 0.1855
Entamoeba histolytica protein kinase, putative 0.0036 0.0296 0.5603
Loa Loa (eye worm) hypothetical protein 0.0046 0.046 0.3076
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Trypanosoma brucei glucose transporter 1E 0.0036 0.0295 0.5889
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0501 0.0501
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0278 0.5537
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0296 0.0296
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0287 0.5725
Brugia malayi cell division control protein 2 homolog 0.0049 0.0501 0.335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0222 0.1484
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 0.1918
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 0.1918
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0034 0.0686
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0054 0.0054
Schistosoma mansoni glucose transport protein 0.0115 0.1496 0.1496
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0054 0.0054
Trichomonas vaginalis esterase, putative 0.0035 0.0287 0.1918
Loa Loa (eye worm) hypothetical protein 0.0026 0.0144 0.0961
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0296 0.0414
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0501 0.335
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0034 0.0048
Schistosoma mansoni hypothetical protein 0.0066 0.0764 0.0764
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0278 0.0278
Plasmodium vivax protein kinase Crk2 0.0049 0.0501 0.0701
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0501 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0295 0.1973
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0054 0.0364
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0054 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0287 0.091
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0501 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 0.1918
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0287 0.5725
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0287 0.091
Mycobacterium leprae Probable lipase LipE 0.0035 0.0287 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0034 0.0034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0034 0.0686
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0501 0.0501
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0144 0.0144
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0296 0.0414
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0054 0.0054
Leishmania major glucose transporter, lmgt3 0.0036 0.0295 0.5889
Schistosoma mansoni protein kinase 0.0036 0.0296 0.0296
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0144 0.0144
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0501 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.091
Echinococcus multilocularis GPCR, family 2 0.0031 0.0222 0.0222
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0287 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1231 0.8225
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0287 0.091
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0222 0.1484
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0144 0.5012
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0054 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0054 0.0054
Echinococcus granulosus FTZ F1 alpha 0.002 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0501 0.0501
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.091
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0364 0.7264
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0054 0.0364
Loa Loa (eye worm) hypothetical protein 0.0028 0.018 0.12
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0144 0.2869
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0364 0.0509
Brugia malayi steroid hormone receptor 0.002 0.0054 0.0364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0222 0.0222
Schistosoma mansoni nuclear hormone receptor 0.002 0.0054 0.0054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0222 0.1484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.1855
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1231 0.8225
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0501 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0034 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0054 0.0364
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0296 0.0296
Plasmodium falciparum mitogen-activated protein kinase 2 0.0186 0.2576 0.3602
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0054 0.0054
Onchocerca volvulus 0.0035 0.0287 1
Brugia malayi beta-lactamase family protein 0.0035 0.0287 0.1918
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.091
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0144 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0364
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0222 0.0222
Leishmania major glucose transporter, lmgt1 0.0036 0.0295 0.5889
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0278 0.0278
Loa Loa (eye worm) beta-lactamase 0.0035 0.0287 0.1918
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0054 0.0364
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0054 0.0364
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0501 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0054 0.0054
Trypanosoma brucei glucose transporter, putative 0.0036 0.0295 0.5889
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0296 0.0414
Toxoplasma gondii exonuclease III APE 0.0018 0.0034 0.0073
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.1496 0.1496
Schistosoma mansoni glucose transport protein 0.0115 0.1496 0.1496
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0054 0.0364
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0034 0.023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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