Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0021 | 0.3155 | 0.4254 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.4143 | 0.4558 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.4229 | 0.4065 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0045 | 0.9402 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.4229 | 0.3988 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.1965 | 0.241 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.463 | 0.481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.297 | 0.172 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.4229 | 0.4065 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.4032 | 0.5436 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.463 | 0.481 |
Loa Loa (eye worm) | acyl carrier protein | 0.0011 | 0.0748 | 0.0423 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.4229 | 0.4065 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.4875 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.3055 | 0.4119 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.0391 | 0.0527 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.3806 | 0.4147 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.3806 | 0.5131 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.463 | 0.481 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.4229 | 0.4065 |
Brugia malayi | hypothetical protein | 0.0027 | 0.4875 | 0.4661 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.3806 | 0.3547 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.7417 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.4032 | 0.5436 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.463 | 0.481 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.4875 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.4875 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.2414 | 0.3255 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.4229 | 0.4065 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0965 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.4875 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.8611 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.463 | 0.9359 |
Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.4229 | 0.4065 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.7417 | 1 |
Onchocerca volvulus | 0.0023 | 0.3806 | 0.3783 | |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.4229 | 0.5702 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.4875 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.463 | 0.481 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.463 | 0.6242 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0965 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1395 | 0.1211 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.297 | 0.172 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.4229 | 0.5702 |
Mycobacterium ulcerans | thioesterase | 0.0021 | 0.3155 | 0.2064 |
Mycobacterium ulcerans | thioesterase TesA | 0.0021 | 0.3155 | 0.2064 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.4875 | 0.545 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.4875 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.4229 | 0.5702 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.463 | 0.6242 |
Brugia malayi | hypothetical protein | 0.0018 | 0.2362 | 0.2043 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.463 | 0.6242 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.4229 | 0.4065 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.4875 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.463 | 0.481 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.7417 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.4875 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.9002 | 0.9555 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.1448 | 0.1953 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.297 | 0.172 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.2372 | 0.3471 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0021 | 0.3155 | 0.2064 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.7417 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.