Detailed information for compound 552127

Basic information

Technical information
  • TDR Targets ID: 552127
  • Name: 2-[5-methoxy-2-methyl-1-[(E)-3-phenylprop-2-e noyl]indol-3-yl]acetic acid
  • MW: 349.38 | Formula: C21H19NO4
  • H donors: 1 H acceptors: 3 LogP: 3.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)/C=C/c1ccccc1)C
  • InChi: 1S/C21H19NO4/c1-14-17(13-21(24)25)18-12-16(26-2)9-10-19(18)22(14)20(23)11-8-15-6-4-3-5-7-15/h3-12H,13H2,1-2H3,(H,24,25)/b11-8+
  • InChiKey: NKPPORKKCMYYTO-DHZHZOJOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[5-methoxy-2-methyl-1-[(E)-1-oxo-3-phenylallyl]-3-indolyl]acetic acid
  • 2-[5-methoxy-2-methyl-1-[(E)-3-phenylprop-2-enoyl]indol-3-yl]ethanoic acid
  • 2-[5-methoxy-2-methyl-1-[(E)-3-phenylacryloyl]indol-3-yl]acetic acid
  • cinmethacin
  • 2-[5-methoxy-2-methyl-1-[(E)-1-oxo-3-phenylprop-2-enyl]-3-indolyl]acetic acid
  • 20168-99-4
  • 1-Cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid
  • 1-Cinnamoyl-5-methoxy-2-methylindole-3-acetic acid
  • 1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)- (9CI)
  • 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid
  • Cindomet
  • Cinmetacin
  • Cinmetacin [INN]
  • Cinmetacina [INN-Spanish]
  • Cinmetacina [Spanish]
  • Cinmetacine [INN-French]
  • Cinmetacinum [INN-Latin]
  • EINECS 243-555-6
  • INDOLE-3-ACETIC ACID, 1-CINNAMOYL-5-METHOXY-2-METHYL-
  • Indolacin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0131 0.0595
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3679 0.3595
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0634 0.7811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0575 0.2619
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0514 0.1887
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0131 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Leishmania major hypothetical protein, conserved 0.0015 0.0131 0.0123
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0529 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0538 0.6356
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0634 0.7811
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Brugia malayi major facilitator superfamily protein 0.0015 0.0131 0.0039
Schistosoma mansoni glucose transport protein 0.0106 0.2198 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Schistosoma mansoni sugar transporter 0.0015 0.0131 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0587 0.7098
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0587 0.2671
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0587 0.2671
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Schistosoma mansoni hypothetical protein 0.0106 0.2198 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0529 0.1958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0123 0.0558
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0514 0.1887
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0777 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0329 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0587 0.2671
Onchocerca volvulus 0.0035 0.0587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0575 0.2619
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0777 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0587 0.2238
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0587 0.2238
Brugia malayi beta-lactamase 0.0035 0.0587 0.2238
Toxoplasma gondii protein kinase, putative 0.0301 0.6588 1
Schistosoma mansoni glucose transport protein 0.0106 0.2198 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0634 0.0962
Mycobacterium leprae Probable lipase LipE 0.0035 0.0587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0633 0.288
Trypanosoma brucei sugar transporter, putative 0.0015 0.0131 0.0123
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0329 0.1499
Brugia malayi Sugar transporter family protein 0.0015 0.0131 0.0039
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0329 0.0996
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0587 0.2238
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0777 1
Plasmodium vivax hexose transporter 0.0106 0.2198 0.2094
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0483 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0777 0.3535
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Echinococcus multilocularis solute carrier family 22 0.0015 0.0131 0.0039
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0131 0.0595
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0529 0.0404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0777 0.3153
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0263 0.1198
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0131 0.0039
Echinococcus granulosus solute carrier family 22 0.0015 0.0131 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0587 0.0963
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2198 1
Brugia malayi beta-lactamase family protein 0.0035 0.0587 0.2238
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0131 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0123 0.0558
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0576 0.6934
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0587 0.2238
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0538 0.245
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0201 0.1204
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0483 0.1739
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0587 0.0963
Loa Loa (eye worm) sugar transporter 0.0106 0.2198 1
Leishmania major protein kinase, putative 0.0033 0.0529 0.6211
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0538 0.6356
Echinococcus multilocularis solute carrier family 22 0.0015 0.0131 0.0039
Trypanosoma cruzi hexose transporter, putative 0.0018 0.02 0.1186
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0587 0.2238
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0538 0.6356
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0587 0.0963
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0587 0.0963
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Mycobacterium tuberculosis Conserved protein 0.0035 0.0587 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0323 0.1471
Brugia malayi Cam kinase protein 1 0.0033 0.0529 0.1958
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0131 0.0595
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0131 0.0039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0529 0.2407
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Brugia malayi hypothetical protein 0.0015 0.0131 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis esterase, putative 0.0035 0.0587 0.2671
Loa Loa (eye worm) beta-lactamase 0.0035 0.0587 0.2671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0529 0.1958
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0529 0.0404
Brugia malayi hypothetical protein 0.0015 0.0131 0.0039
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0131 0.0123
Trypanosoma brucei glucose transporter 1E 0.0033 0.0538 0.6356
Loa Loa (eye worm) hypothetical protein 0.0035 0.0587 0.2671
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0587 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2198 0.3336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0529 0.0804
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0258 0.207
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0529 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0381 0.1732
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Leishmania major hypothetical protein, conserved 0.0035 0.0587 0.7098
Onchocerca volvulus 0.0035 0.0587 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0131 0.0039
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0329 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0375 0.1706
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0777 1
Mycobacterium ulcerans sugar transporter 0.0015 0.0131 0.1544
Toxoplasma gondii ABC1 family protein 0.0035 0.0587 0.0891
Brugia malayi hypothetical protein 0.0015 0.0131 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0538 0.6356
Echinococcus granulosus solute carrier family 22 0.0015 0.0131 0.0039
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0329 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0777 0.3535
Echinococcus granulosus solute carrier family 22 0.0015 0.0131 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0538 0.245
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0538 0.245
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0587 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0575 0.2619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0381 0.1732
Entamoeba histolytica protein kinase, putative 0.0033 0.0529 0.4461
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0131 0.1544
Brugia malayi major facilitator superfamily protein 0.0015 0.0131 0.0039
Toxoplasma gondii sugar transporter ST1 0.0015 0.0131 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0777 0.3535
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Loa Loa (eye worm) hypothetical protein 0.0026 0.0379 0.1724
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0514 0.1887
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0514 0.2339
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0634 0.051
Trypanosoma brucei glucose transporter 2A 0.0033 0.0538 0.6356
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0587 0.2671
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0777 1
Schistosoma mansoni glucose transport protein 0.0106 0.2198 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0529 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0131 0.0039
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0131 0.0123
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Leishmania major glucose transporter, lmgt2 0.0033 0.0538 0.6356
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0248 0.0249
Loa Loa (eye worm) hypothetical protein 0.0035 0.0587 0.2671
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0329 0.316
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0634 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0123 0.0558
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0529 0.2407
Schistosoma mansoni sugar transporter 0.0015 0.0131 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0514 0.2339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0329 0.3075
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0131 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0131 0.1544
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0575 0.2619
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0047 0.5
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0529 0.1958
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0131 0.0595
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0324 0.1475
Mycobacterium tuberculosis Conserved protein 0.0035 0.0587 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0123 0.0558
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0576 0.6934
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0538 0.6356
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0131 0.0595
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0634 0.7811
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0777 1
Onchocerca volvulus 0.0035 0.0587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0324 0.1475
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.4868 1
Schistosoma mansoni protein kinase 0.0033 0.0529 0.1958
Schistosoma mansoni protein kinase 0.0033 0.0529 0.1958
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0329 0.316
Schistosoma mansoni sugar transporter 0.0015 0.0131 0.0039
Giardia lamblia GTOR 0.0044 0.0777 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0131 0.0039
Mycobacterium ulcerans lipase LipD 0.0035 0.0587 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0131 0.0595
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0538 0.245
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0529 0.2407
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0131 0.0595
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0529 0.0404
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0777 0.3153
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0777 0.3153
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0587 0.7098
Echinococcus granulosus solute carrier family 22 0.0015 0.0131 0.0039
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0514 0.1887
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0777 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0587 0.0462
Toxoplasma gondii sugar transporter ST3 0.0015 0.0131 0.0198
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3679 0.5584
Mycobacterium ulcerans beta-lactamase 0.0035 0.0587 1
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2198 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Brugia malayi Sugar transporter family protein 0.0015 0.0131 0.0039
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0529 0.0804
Echinococcus multilocularis General substrate transporter 0.0091 0.1859 0.837
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0131 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0538 0.245
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0329 0.239
Trypanosoma brucei glucose transporter, putative 0.0033 0.0538 0.6356
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0538 0.6356
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0329 0.5225
Trypanosoma cruzi hexose transporter 0.0033 0.0538 0.6356
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0329 0.0996
Plasmodium falciparum hexose transporter 0.0106 0.2198 0.2094
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0587 0.0963
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Schistosoma mansoni glucose transporter 0.0015 0.0131 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0514 0.2339
Leishmania major glucose transporter, lmgt3 0.0033 0.0538 0.6356
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0514 0.5933
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0777 0.3153
Plasmodium falciparum protein kinase 7 0.0301 0.6588 0.6542
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0089 0.0404
Toxoplasma gondii sugar transporter ST2 0.0015 0.0131 0.0198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0587 0.2671
Loa Loa (eye worm) hypothetical protein 0.0035 0.0587 0.2671
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0529 0.6211
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0514 0.7846
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0131 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Echinococcus granulosus General substrate transporter 0.0091 0.1859 0.837
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0329 0.05
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0131 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0453 0.206
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0587 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0777 0.3535
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0529 0.0404
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0329 0.316
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0576 0.6934
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0587 0.7098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0587 0.2671
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0514 0.1887
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Loa Loa (eye worm) hypothetical protein 0.0035 0.0587 0.2671
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0529 0.1958
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0538 0.245
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0587 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0323 0.1471
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0525 0.2387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0375 0.1706
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0634 0.7811
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0538 0.6356
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0131 0.0595
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0634 0.7811
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0514 0.4128
Leishmania major glucose transporter, lmgt1 0.0033 0.0538 0.6356
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0587 0.2671
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0432 0.1964
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0381 0.1732
Entamoeba histolytica protein kinase, putative 0.0033 0.0529 0.4461
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0123 0.0558
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0529 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0057 0.0258
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0131 0.0123
Echinococcus multilocularis solute carrier family 22 0.0015 0.0131 0.0039
Loa Loa (eye worm) sugar transporter 0.0015 0.0131 0.0595
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0329 0.0996
Schistosoma mansoni sugar transporter 0.0015 0.0131 0.0039
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0538 0.245
Mycobacterium ulcerans hypothetical protein 0.0035 0.0587 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Brugia malayi Sugar transporter family protein 0.0106 0.2198 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0324 0.1475
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0777 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0329 0.0201
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0525 0.0796
Plasmodium vivax CDK-related protein kinase 6, putative 0.0452 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0324 0.1475
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0587 0.2671
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0529 0.0404
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0131 0.0595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Mycobacterium tuberculosis Conserved protein 0.0035 0.0587 0.0963
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0587 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0131 0.0039
Brugia malayi beta-lactamase family protein 0.0035 0.0587 0.2238
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0575 0.2619
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0514 0.1887
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0595
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2198 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0131 0.0595
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0131 0.1544
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0248 0.0249
Loa Loa (eye worm) hypothetical protein 0.0024 0.0329 0.1499
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0131 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0123 0.0558
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0529 0.0404
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0529 0.0404
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0329 0.5225
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3679 0.3595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0323 0.1471
Schistosoma mansoni protein kinase 0.0033 0.0529 0.1958

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.