Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Nicastrin, putative | 0.0073 | 0.0019 | 0.004 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.015 | 0.0084 | 0.2512 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | Nicastrin | 0.0199 | 0.0124 | 0.0124 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.0124 | 0.0124 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0408 | 0.0299 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0408 | 0.0299 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0318 | 0.0224 | 0.7373 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0006 | 0.0006 |
Echinococcus multilocularis | Nicastrin | 0.0199 | 0.0124 | 0.0124 |
Echinococcus multilocularis | nicalin | 0.0073 | 0.0019 | 0.0019 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.015 | 0.0084 | 0.0207 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0011 | 0.1378 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0011 | 0.0011 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0006 | 0.0006 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0408 | 0.0299 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4682 | 0.3871 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0383 | 0.0278 | 0.0278 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0318 | 0.0224 | 0.0569 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.015 | 0.0084 | 0.0168 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0383 | 0.0278 | 0.0278 |
Mycobacterium ulcerans | hypothetical protein | 0.0167 | 0.0098 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0006 | 0.0006 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0115 | 0.0054 | 0.0092 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0198 | 0.0123 | 0.0123 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.2016 | 1 | 1 |
Echinococcus granulosus | nicalin | 0.0073 | 0.0019 | 0.0019 |
Brugia malayi | Presenilin spe-4 | 0.0143 | 0.0078 | 0.0078 |
Echinococcus multilocularis | presenilin | 0.0408 | 0.0299 | 0.0299 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0383 | 0.0278 | 0.0278 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0408 | 0.0299 | 0.0299 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0006 | 0.0006 |
Brugia malayi | Presenilin spe-4 | 0.0143 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0006 | 0.0006 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0408 | 0.0299 | 0.0727 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0318 | 0.0224 | 0.0569 |
Echinococcus granulosus | presenilin | 0.0408 | 0.0299 | 0.0299 |
Brugia malayi | hypothetical protein | 0.0143 | 0.0078 | 0.0078 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0167 | 0.0098 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0408 | 0.0299 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0115 | 0.0054 | 0.1493 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0006 | 0.0006 |
Brugia malayi | hypothetical protein | 0.0143 | 0.0078 | 0.0078 |
Brugia malayi | hypothetical protein | 0.0199 | 0.0124 | 0.0124 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0143 | 0.0078 | 0.0078 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0318 | 0.0224 | 0.0531 |
Trypanosoma brucei | Aph-1 protein, putative | 0.4682 | 0.3871 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0408 | 0.0299 | 0.0764 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.0078 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.0213 | 0.0213 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0408 | 0.0299 | 0.0764 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0143 | 0.0078 | 0.0078 |
Brugia malayi | Presenilin family protein | 0.0408 | 0.0299 | 0.0299 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0408 | 0.0299 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0006 | 0.0006 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0011 | 0.0011 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.2016 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.0054 | 0.6982 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0626 | 0.0481 | 0.0481 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.2016 | 1 | 1 |
Brugia malayi | Presenilin spe-4 | 0.0143 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.2016 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0383 | 0.0278 | 0.0278 |
Echinococcus granulosus | Nicastrin | 0.0199 | 0.0124 | 0.0124 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0006 | 0.0006 |
Trypanosoma cruzi | Nicastrin, putative | 0.0073 | 0.0019 | 0.004 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0011 | 0.0011 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0198 | 0.0123 | 0.0123 |
Brugia malayi | hypothetical protein | 0.0199 | 0.0124 | 0.0124 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4682 | 0.3871 | 1 |
Brugia malayi | hypothetical protein | 0.0143 | 0.0078 | 0.0078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.