Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.444 | 0.444 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0479 | 0.0479 |
Echinococcus granulosus | adam | 0.0057 | 0.1522 | 0.1294 |
Loa Loa (eye worm) | reprolysin | 0.0094 | 0.3345 | 0.3345 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0479 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1992 | 0.1992 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0262 | 0.0262 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0479 | 0.0223 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0262 | 0.0262 |
Brugia malayi | hypothetical protein | 0.0057 | 0.1522 | 0.1522 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0057 | 0.1522 | 0.4088 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1061 | 0.2592 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.444 | 0.444 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.444 | 0.444 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0094 | 0.3345 | 0.3166 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3484 | 0.3484 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0094 | 0.3345 | 1 |
Brugia malayi | Reprolysin | 0.0076 | 0.2473 | 0.2473 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0479 | 0.0223 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0262 | 0.0262 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1992 | 0.1992 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.3484 | 0.3484 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1061 | 0.2592 |
Onchocerca volvulus | 0.0047 | 0.1061 | 0.5 | |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0094 | 0.3345 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0094 | 0.3345 | 0.3166 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0479 | 0.0704 |
Echinococcus multilocularis | adam | 0.0057 | 0.1522 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0262 | 0.0262 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.3484 | 0.3484 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1992 | 0.5613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.